Progesterone R/NR3C3 Antibody (Alpha PR6)

Images

 
Immunohistochemistry-Paraffin: Progesterone R/NR3C3 Antibody (Alpha PR6) [NB120-2765] - Staining of human uterus tissue.

Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, Ch, Gp, Pm, Rb, ShSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Clone
Alpha PR6
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Progesterone R/NR3C3 Antibody (Alpha PR6) Summary

Immunogen
Progesterone receptor purified from chick oviduct cytosol.
Localization
Nuclear
Specificity
Detects the B form of the progesterone receptor (PR). This does not cross-react with estrogen receptor or glucocorticoid receptor.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
PGR
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/ml
  • Immunocytochemistry/Immunofluorescence 10 ug/ml
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Frozen 20 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Immunoprecipitation 1:10 - 1:500
Application Notes
WB: Detects an approx. 110 kDa protein representing the B form of the PR in chickens and rabbits as well a 120 kDa doublet or triplet bands in humans.
Publications
Read Publication using NB120-2765.

Reactivity Notes

Primate reactivity reported in scientific literature (PMID: 18980817). Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
LYOPH
Purity
Protein A purified
Reconstitution Instructions
Reconstitute with sterilized PBS.

Alternate Names for Progesterone R/NR3C3 Antibody (Alpha PR6)

  • NR3C3
  • NR3C3PRNuclear receptor subfamily 3 group C member 3
  • PGR
  • Progesterone R
  • progesterone receptor
  • ProgesteroneR

Background

The human Progesterone Receptor (PgR) is a member of the steroid family of nuclear receptors. PgR is found as a 120 kDa protein (Form B) or a 94 kDa protein (Form A) due to the use of alternative translation initiation sites. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Progesterone R/NR3C3 Antibody (NB120-2765)(1)

Reviews for Progesterone R/NR3C3 Antibody (NB120-2765) (0)

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Progesterone R/NR3C3 Antibody (NB120-2765). (Showing 1 - 1 of 1 FAQ).

  1. I am interested in getting antibodies for PR (progesterone receptor) that would work in flow cytometry. Could you recommend some choices?
    • We do not currently have any antibodies directed towards the progesterone receptor that have been validated in flow cytometry, but any of our antibodies that work in ICC should work just fine in flow as they are essentially the same application. Please see this link for our Progesterone Receptor antibodies validated in ICC.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NB120-2765AF350
Alexa Fluor 405 NB120-2765AF405
Alexa Fluor 488 NB120-2765AF488
Alexa Fluor 532 NB120-2765AF532
Alexa Fluor 594 NB120-2765AF594
Alexa Fluor 647 NB120-2765AF647
Alexa Fluor 700 NB120-2765AF700
Alexa Fluor 750 NB120-2765AF750
DyLight 350 NB120-2765UV
DyLight 405 NB120-2765V
DyLight 488 NB120-2765G
DyLight 594 NB120-2765DL594
DyLight 650 NB120-2765C
DyLight 680 NB120-2765FR
DyLight 755 NB120-2765IR
Janelia Fluor 549 NB120-2765JF549
Janelia Fluor 646 NB120-2765JF646

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Diseases for Progesterone R/NR3C3 Antibody (NB120-2765)

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Contact Information

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Bioinformatics

Gene Symbol PGR
Entrez
Uniprot