PRMT6 Antibody

Images

 
Western Blot: PRMT6 Antibody [NB110-40713] - Detection of Human PRMT6 on HeLa whole cell lysate using NB110-40713. PRMT6 was also immunoprecipitated by rabbit anti-PRMT6 antibody NB110-40712.
Immunohistochemistry: PRMT6 Antibody [NB110-40713] - Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti- PRMT6 used at a dilution of 1:5,000 (0.2 ug/ml). Detection: DAB
Immunohistochemistry-Paraffin: PRMT6 Antibody [NB110-40713] - FFPE section of mouse teratoma. Affinity purified rabbit anti-PRMT6 used at a dilution of 1:250.
Immunohistochemistry-Paraffin: PRMT6 Antibody [NB110-40713] - See Notes, IHC Caption B

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P, IP (-)
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml
 

Independent Antibodies

 

Biological Strategies

     

Order Details

PRMT6 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 325 and the C-terminus (residue 375) of human Protein Arginine Methyltransferase 6 using the numbering given in entry AAK85733.1 (GeneID 55170).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PRMT6
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:2000-1:10000
  • Immunohistochemistry 1:250
  • Immunohistochemistry-Paraffin 1:250
Application Notes
This antibody is useful for Western Blot.Immunoprecipitation is not recommended. Use NB 110-40712.
Positive Control
PRMT6 Lysate (NBL1-14796)
Publications
Read Publications using NB110-40713.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PRMT6 Antibody

  • EC 2.1.1.-
  • EC 2.1.1.125
  • FLJ10559
  • FLJ51477
  • Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6
  • Histone-arginine N-methyltransferase PRMT6
  • HMT1 hnRNP methyltransferase-like 6 (S. cerevisiae)
  • HMT1 hnRNP methyltransferase-like 6
  • HRMT1L6
  • protein arginine methyltransferase 6
  • protein arginine N-methyltransferase 6

Background

PRMT6 severely impairs the function of HIV-1 Rev. PRMT6 is a protein arginine N-methyltransferase, and catalyzes the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation is a prevalent post-translational modification in eukaryotic cells that has been implicated in signal transduction, the metabolism of nascent pre-RNA, and the transcriptional activation processes. In addition, PRMT6 displays automethylation activity; it is the first PRMT to do so. PRMT6 has been shown to act as a restriction factor for HIV replication.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PRMT6 Antibody (NB110-40713)(2)

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for PRMT6 Antibody (NB110-40713) (0)

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for PRMT6 Antibody (NB110-40713)

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Blogs on PRMT6.

PRMT6: One Function, Many Roles
Protein arginine methylation is a prevalent posttranslational modification in eukaryotic cells. It regulates RNA processing, trafficking and nascent pre-RNA metabolism, receptor-mediated signal transduction, and transcriptional activation processes. P...  Read full blog post.

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Bioinformatics

Gene Symbol PRMT6
Entrez
Uniprot