PRDC/GREM2 Antibody (377407)

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB
Clone
377407
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
LYOPH

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PRDC/GREM2 Antibody (377407) Summary

Immunogen
E. coli-derived recombinant mouse PRDC/GREM2
Arg22-Gln168
Accession # O88273
Specificity
Detects mouse PRDC/GREM2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant mouse (rm) DAN, rmCerberus, rmGremlin, or rmCoco is observed.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
GREM2
Purity
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PRDC/GREM2 Antibody (377407)

  • CKTSF1B2
  • CKTSF1B2FLJ21195
  • Cysteine knot superfamily 1, BMP antagonist 2
  • DAN domain family member 3
  • DAND3
  • DAND3Prdc
  • GREM2
  • gremlin 2
  • gremlin 2, cysteine knot superfamily, homolog
  • gremlin-2
  • PRDC
  • PRDCgremlin 2, cysteine knot superfamily, homolog (Xenopus laevis)
  • Protein related to DAN and cerberus

Background

PRDC (protein related to DAN and Cerberus), also called GREM2 (Gremlin-2), is a secreted cysteine knot-containing BMP antagonist belonging to the Cerberus/DAN (CAN) family. Mammalian CAN family members, including Gremlin, Dan, Cerberus, COCO, SOST, and USAG-1, have the conserved 6 cysteine residues that form a cysteine knot, and two additional cysteine residues located in the loops of the cysteine knot, which form an additional intrasubunit disulfide bond (1, 2). Some members of this family, including PRDC, have an additional cysteine residue used for dimerization (1, 2). Of all the CAN family members, PRDC is most closely related to Gremlin, displaying 52% amino acid (aa) sequence identity. PRDC was first identified in a screen for developmentally regulated genes by gene trapping in embryonic stem cells (3). PRDC expression is detected by in situ hybridization in the dorsal edge of the spinal cord at E10.5, in commissural neurons in the caudal part of the spinal cord two days later (3), and in the granulosa cells of selective ovarian follicles (4). In the adult, abundant levels of PRDC are detected by RT-PCR in the mouse ovary, brain, and spleen, and to a lesser degree in the colon, kidney, lung, liver, and uterus (4). PRDC acts as a specific BMP antagonist, binding to and blocking signaling induced by BMP-2 or -4, but not Activin or TGF-beta (4). Thus, PRDC expression in the ovary could be involved in follicular development by antagonizing the inhibitory effects of BMPs on FSH stimulation of progesterone (4). Mouse PRDC shows 94% aa sequence identity with human PRDC.

  1. Pearce, J. et al. (1999) Dev. Biol. 209:99.
  2. Avsian-Kretchmer, O. and A. Hsueh (2004) Molecular Endocrinology 18:1.
  3. Minabe-Saegusa, C. et al. (1998) Develop. Growth Differ. 40:343.
  4. Sudo, S. et al. (2004) Jour. Biol. Chem. 279:23134.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GREM2
Uniprot