PON2 Antibody

Images

 
Western Blot: PON2 Antibody [NBP1-52005] - HepG2 lysate (35ug protein in RIPA buffer) using NBP1-52005 at 0.2ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

PON2 Antibody Summary

Immunogen
Peptide with sequence C-EKPRARELRIS corresponding to internal region according to NP_000296.2, NP_001018171.1.
Epitope
C-EKPRARELRIS
Specificity
This antibody is expected to recognize isoforms 1 and 2 (NP_000296.2; NP_001018171.1).
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
PON2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.2 - 0.6 ug/ml
  • Peptide ELISA Detection limit 1:32000
Application Notes
WB: Approx. 40 kDa band double band observed in lysates of HepG2 (calculated MW of 39.4 kDa band according to NP_000296.2 and of 38.0 kDa band according to NP_001018171.1). An additional band of unknown identity was also consistently observed at 60 kDa. This band was successfully blocked by incubation with the immunizing peptide.
Publications
Read Publication using NBP1-52005.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Rat, Porcine, Canine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PON2 Antibody

  • A-esterase 2
  • Aromatic esterase 2
  • EC 3.1.1.2
  • EC 3.1.1.81
  • paraoxonase 2
  • paraoxonase nirs
  • PON 2
  • PON2
  • Serum Aryldialkylphosphatase 2
  • serum paraoxonase/arylesterase 2

Background

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PON2 Antibody (NBP1-52005)(1)


Showing Publication 1 - 1 of 1.
Publication using NBP1-52005 Applications Species
Shin BS. Paraoxonase gene polymorphism in south-western Korean population. J Korean Med Sci 2009 Aug [PMID: 19654933]

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PON2
Entrez
Uniprot