PON2 Products

Description

PON2 encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.

Bioinformatics

Entrez	296851 Rat 5445 Human
Uniprot	AAH46160 Human NM_000305 Human NP_000296.2 Human
Product By Gene ID	5445
Alternate Names	A-esterase 2 Aromatic esterase 2 EC 3.1.1.2 EC 3.1.1.81 paraoxonase 2 paraoxonase nirs PON 2 Serum aryldialkylphosphatase 2 serum paraoxonase/arylesterase 2