PMEL17/SILV Antibody


Western Blot: PMEL17/SILV Antibody [NBP1-69571] - Sample Tissue: Human MCF7 Antibody Dilution: 1.0 ug/ml
Immunohistochemistry: PMEL17/SILV Antibody [NBP1-69571] - The inflammatory MITFlow/c-Junhigh cell state correlates with increased myeloid cell infiltration in human melanomas. Immunohistochemical analysis for gp100, more
Western Blot: PMEL17/SILV Antibody [NBP1-69571] - This Anti-SILV antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 1.25ug/ml.
Immunohistochemistry: PMEL17/SILV Antibody [NBP1-69571] - Human kidney

Product Details

Reactivity Hu, Mu, Rt, Bv, Eq, Gt, GpSpecies Glossary
Applications WB, IHC, IHC-P

Order Details

PMEL17/SILV Antibody Summary

Synthetic peptides corresponding to SILV(silver homolog (mouse)) The peptide sequence was selected from the N terminal of human PMEL (NP_008859). Peptide sequence HFLRNQPLTFALQLHDPSGYLAEADLSYTWDFGDSSGTLISRALVVTHTY. The peptide sequence for this immunogen was taken from within the described region.
Melanosome Marker
Predicted Species
Rat (93%), Goat (93%), Equine (93%), Bovine (93%), Guinea Pig (93%). Backed by our 100% Guarantee.
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 1.25 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1.25 ug/ml
Application Notes
This is a rabbit polyclonal antibody against SILV and was validated on Western Blot and immunohistochemistry.
Theoretical MW
70 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publications using
NBP1-69571 in the following applications:

  • IHC
    2 publications
  • 3 publications
  • WB
    1 publication

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 26511633).

Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
PBS and 2% Sucrose
0.09% Sodium Azide
Protein A purified


The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Alternate Names for PMEL17/SILV Antibody

  • D12S53EP1
  • Gp100
  • ME20
  • ME20M
  • ME20-M
  • melanocyte protein mel 17
  • Melanocyte protein Pmel 17
  • Melanocytes lineage-specific antigen GP100
  • Melanoma-associated ME20 antigen
  • melanosomal matrix protein17
  • PMEL
  • PMEL17
  • PMEL17P100
  • premelanosome proteinME20M
  • SI
  • SIL
  • SILV
  • silver (mouse homolog) like
  • silver homolog (mouse)
  • Silver locus protein homolog
  • silver, mouse, homolog of
  • SILVPmel17


SILV could be a melanogenic enzyme. It could represent an oncofetal self-antigen that is normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth. Release of the soluble form, ME20-S, it could protect tumor cells from antibody mediated immunity.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PMEL17/SILV Antibody (NBP1-69571)(7)

We have publications tested in 2 confirmed species: Mouse, Human;Mouse.

We have publications tested in 3 applications: IHC, IHC-P, WB.

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Showing Publications 1 - 7 of 7.
Publications using NBP1-69571 Applications Species
Forsthuber A, Lipp K, Andersen L et al. CXCL5 as Regulator of Neutrophil Function in Cutaneous Melanoma J. Invest. Dermatol. Jan 1 2019 [PMID: 30009831] (IHC, Mouse) IHC Mouse
Riesenberg S, Groetchen A, Siddaway R et al. MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment. Nat Commun. 2015 Nov 04 [PMID: 26530832] (IHC-P, Mouse) IHC-P Mouse
Holzel M, Landsberg J, Glodde N et al. A preclinical model of malignant peripheral nerve sheath tumor-like melanoma is characterized by infiltrating mast cells. Cancer Res. 2015 Oct 28 [PMID: 26511633] (IHC-P, Human;Mouse) IHC-P Human;Mouse
Bald T, Quast T, Landsberg J et al. Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma. Nature 2014 Mar 6 [PMID: 24572365] (IHC-P, Mouse) IHC-P Mouse
Theos AC, Truschel ST, Tenza D et al. A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis. Dev Cell. 2006 [PMID: 16516837]
Glodde N, Kraut A, van den Boorn-Konijnenberg D Experimental and stochastic models of melanoma T-cell therapy define impact of subclone fitness on selection of antigen loss variants bioRxiv (IHC, Mouse) IHC Mouse
Braun AD, Mengoni M, Bonifatius S et al. Activated Hgf-Met signaling cooperates with oncogenic Braf to drive primary cutaneous melanomas and angiotropic lung metastases in mice J. Invest. Dermatol. Jan 20 2020 [PMID: 31972251] (WB) WB

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Gene Symbol PMEL