PKA C alpha Antibody (515741) [Alexa Fluor® 405]

• Applications: WB
• Clone: 515741
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

PKA C alpha Antibody (515741) [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human PKA Cα
  Met1-Phe351
  Accession # P17612
• Specificity: Detects human, mouse, and rat PKA C alpha / beta in Western blots.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

The cAMP-dependent protein kinase (PKA) holoenzyme is composed of two regulatory and two catalytic subunits, designated PKA R and PKA C, respectively. Three catalytic subunit isoforms, C alpha , C beta , and C gamma , have been identified. Upon PKA R subunit binding to the second messenger cAMP, active PKA C subunits are released, initiating a phosphorylation cascade that regulates such cellular functions as metabolism, ion transport, and gene transcription.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.