PI 3-Kinase p110 gamma Antibody

Product Discontinued

PI 3-Kinase p110 gamma Antibody Summary

• Immunogen: Synthetic peptide VLGIKQGEKHSA, representing the C-Terminus of the human protein (residues 1091-1102), according to NP_002640.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: PIK3CG
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA detection limit 1:2000
  • Western Blot 1-3 ug/ml
• Application Notes: Western blot: Approx 110-120kDa band seen in Human Heart lysate (Predicted MW of 121kDa according to NP_002640).
• Control:

  Human Heart Whole Tissue Lysate (Adult Whole Normal)
  PI 3-Kinase p110 gamma Overexpression Lysate

Reactivity Notes

Cross reacts with Human. Expected from sequence similarity: Rat, Mouse and Dog.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PI 3-Kinase p110 gamma Antibody

• 1-phosphatidylinositol 3-kinase
• EC 2.7.1
• EC 2.7.1.153
• p110-gamma
• p120-PI3K
• phosphatidylinositol 3 kinase gamma, p110 gamma
• phosphatidylinositol 3-kinase catalytic 110-kD gamma
• phosphatidylinositol 3-kinase, catalytic, gamma polypeptide
• Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma
• phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
• phosphoinositide-3-kinase gamma catalytic subunit
• phosphoinositide-3-kinase, catalytic, gamma polypeptide
• PI 3Kinase p110 gamma
• PI 3-Kinase p110 gamma
• PI3CG
• PI3K
• PI3K-gamma
• PI3Kgamma
• PI3K-gamma
• PI3-kinase subunit gamma
• PIK3
• PIK3CG
• PtdIns-3-kinase subunit gamma
• PtdIns-3-kinase subunit p110-gamma

Background

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PIK3CG
• Entrez:
  • 5294(Human)
  • 30955(Mouse)
• Uniprot:
  • NP_002640.(Human)