Peptidylglycine alpha-Amidating Monooxygenase/PAM Antibody [Janelia Fluor® 646]

• Reactivity: Hu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Janelia Fluor 646

Peptidylglycine alpha-Amidating Monooxygenase/PAM Antibody [Janelia Fluor® 646] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human PAM
  Phe21-Val817
  Accession # P19021
• Specificity: Detects human PAM in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: PAM
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Peptidylglycine alpha-Amidating Monooxygenase/PAM Antibody [Janelia Fluor® 646]

• PAL
• PAM
• pancreatic peptidylglycine alpha-amidating monooxygenase
• peptidyl alpha-amidating enzyme
• peptidyl-alpha-hydroxyglycine alpha-amidating lyase
• peptidylamidoglycolate lyase
• peptidylglycine 2-hydroxylase
• peptidyl-glycine alpha-amidating monooxygenase
• peptidylglycine alpha-amidating monooxygenase
• peptidylglycine alpha-hydroxylating monooxygenase
• PHM

Background

PAM encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PAM