PDGFR alpha Antibody

Immunohistochemistry-Paraffin: PDGFR alpha Antibody [NBP1-40031] - Staining of human breast, fibroblasts tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Product Discontinued

PDGFR alpha Antibody Summary

• Immunogen: A synthetic peptide derived from the C-terminus of the precursor form of human PDGFR alpha.
• Epitope: C-Terminus
• Specificity: Specific for PDGFR alpha and does not react with PDGFR beta.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PDGFRA
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4) and 0.2% BSA
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein A purified

Alternate Names for PDGFR alpha Antibody

• alpha-type platelet-derived growth factor receptor
• CD140 antigen-like family member A
• CD140a antigen
• CD140a
• EC 2.7.10
• EC 2.7.10.1
• MGC74795
• PDGF R alpha
• PDGFR alpha
• PDGFR2
• PDGFRA
• PDGFRA/BCR fusion
• PDGF-R-alpha
• platelet-derived growth factor receptor, alpha polypeptide
• rearranged-in-hypereosinophilia-platelet derived growth factor receptor alphafusion protein
• RHEPDGFRA

Background

Platelet derived growth factor receptor (PDGF Receptor) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo or heterodimerization into complexes of alpha and beta subunits upon ligand binding, depending on the isoform of PDGF (PDGF AA, BB or AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation, and also lead to activation of the Ras, Raf and ERK 1 and 2 pathway. This Ab blocks PDGF Receptor alpha mediated biological activity induced by PDGF-AA.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PDGFRA
• Entrez:
  • 5156(Human)
• Uniprot:
  • P16234()