PDE6 beta Products

Description

Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Bioinformatics

Uniprot	NM_000283 Human P23440 Mouse P35913 Human
Product By Gene ID	5158
Alternate Names	CSNB3 EC 3.1.4 EC 3.1.4.35 GMP-PDE beta PDEBrod cGMP-phosphodiesterase beta-subunit phosphodiesterase 6B, cGMP-specific, rod, beta rd1 rod cGMP-specific 3'-5'-cyclic phosphodiesterase subunit beta RP40CSNBAD2