PD-L2/B7-DC/PDCD1LG2 Antibody (AP-MAB0877) - Azide and BSA Free

Product Discontinued

PD-L2/B7-DC/PDCD1LG2 Antibody (AP-MAB0877) - Azide and BSA Free Summary

• Immunogen: Mouse B7-DC recombinant protein
• Isotype: IgG2
• Clonality: Monoclonal
• Host: Rat
• Gene: PDCD1LG2
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Block/Neutralize
  • CyTOF-ready
  • Flow Cytometry 1:10-1:1000
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:100-1:2000
• Application Notes: Flow Cytometry, Immunoprecipitation, Western Blot, and Blocking PD-1 mediated interactions. Extremely low level of LPS (< 0.002EU/ug IgG). This antibody is CyTOF ready.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Concentration: 1.0 mg/ml
• Purity: Protein A or G purified

Alternate Names for PD-L2/B7-DC/PDCD1LG2 Antibody (AP-MAB0877) - Azide and BSA Free

• B7-DC
• bA574F11.2
• Btdc
• Butyrophilin B7-DC
• Butyrophilin-like Protein
• CD273 antigen
• CD273
• CD273PD-1 ligand 2
• MGC142240
• PD-1-ligand 2
• PDCD1L2MGC142238
• PDCD1LG2
• PDL2
• PD-L2
• PDL2B7DC
• PD-L2PDCD1 ligand 2
• programmed cell death 1 ligand 2
• Programmed death ligand 2

Background

B7-DC is also called programmed death ligand 2 (PDL2). It has recently been clustered as CD273. This ligand is a 42 kD member of the immunoglobulin receptor superfamily expressed on a subset of dendritic cells, liver and a small subset of macrophages as well as a few transformed cell lines. B7-DC (CD273) has been reported to be stimulatory on dendritic cells when cross-linked and to inhibit T cell activation upon engaging the PD-1 receptor. B7-DC (CD273) has also been reported to bind to an alternative receptor and to mediate T cell activation through such non-PD1 mediated interactions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PD-L2/B7-DC/PDCD1LG2 Antibody (NBP1-06698)(1)

Publication using NBP1-06698

• Samuelson DR, de la Rua NM, Charles TP et al. Oral Immunization of Mice with Live Pneumocystis murina Protects against Pneumocystis Pneumonia. J. Immunol. 2016-03-15 [PMID: 26864029]
  
  Details:
  This publication used the PCP conjugated form of this antibody (NBP2-25235PCP)

Bioinformatics

• Gene Symbol: PDCD1LG2
• Entrez:
  • 58205(Mouse)