PD-L2/B7-DC/PDCD1LG2 Antibody (988708) [Alexa Fluor® 350] Summary
Mouse myeloma cell line NS0-derived recombinant human PD-L2/B7-DC
Accession # Q9BQ51
Detects human PD-L2/B7-DC in direct ELISAs.
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Flow Cytometry 0.25-1 ug/10^6 cells
Packaging, Storage & Formulations
|Protect from light. Do not freeze.
- 12 months from date of receipt, 2 to 8 °C as supplied.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for PD-L2/B7-DC/PDCD1LG2 Antibody (988708) [Alexa Fluor® 350]
- Butyrophilin B7-DC
- Butyrophilin-like Protein
- CD273 antigen
- CD273PD-1 ligand 2
- PD-1-ligand 2
- PD-L2PDCD1 ligand 2
- programmed cell death 1 ligand 2
- Programmed death ligand 2
T cells require a signal induced by the engagement of the T cell receptor and a “co‑stimulatory” signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. Members of the B7 superfamily of counter-receptors were identified by their ability to interact with co‑stimulatory molecules found on the surface of T cells. Members of the B7 superfamily include B7-1 (CD80), B7-2 (CD86), B7-H1 (PD-L1), B7-H2 (B7RP-1), B7-H3, and PD-L2 (B7-DC) (1). B7 proteins are immunoglobulin (Ig) superfamily members with extracellular Ig-V-like and Ig-C-like domains and short cytoplasmic domains. Among the family members, they share from 20‑40% amino acid (aa) sequence identity. The cloned human PD-L2 cDNA encodes a 273 aa type I membrane precursor protein with a putative 20 aa signal peptide, a 201 aa extracellular region containing one V-like and one C-like Ig domain, a 24 aa transmembrane region, and a 28 aa cytoplasmic domain. The extracellular domains of mouse and human PD-L2 share approximately 70% aa sequence identity (2). PD-L2 is one of two ligands for programmed death-1 (PD-1), a member of the CD28 family of immuno-receptors. The other identified ligand is PD-L1. Human PD-L1 and PD-L2 share approximately 41% aa sequence identity and have similar functions. PD-L2 is broadly expressed in tissues. Highest expression was detected by Northern blot analysis in heart, placenta, liver, pancreas, spleen, and lymph node. Lower amounts of expression were observed in lung, smooth muscle, and thymus. Expression of PD-L2 on antigen presenting cell has been examined in detail. Resting B cells, monocytes and dendritic cells do not express PD-L2, expression however can be induced by LPS or BCR activation in B cells, INF-gamma treatment in monocytes, or LPS plus IFN-gamma treatment of dendritic cells. PD-L2 expression is also up regulated in a variety of tumor cell lines. On previously activated T cells, PD-L2 interaction with PD-1 inhibits TCR-mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. In contrast, a co‑stimulatory function for the PD-L2 on resting T cells activated with sub-optimal TCR signals has also been reported (3).
- Coyle, A.J. and J-C. Gutierrrez-Ramos (2001) Nature Immunol. 2:203.
- Latchman Y. et al. (2001) Nature Immun. 2:261.
- Carreno, B.M. and M. Collins (2002) Annu. Rev. Immunol. 20:29.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
Customers Who Viewed This Item Also Viewed...
Species: Hu, Mu, Rt
Applications: WB, ELISA, Flow, IHC, IHC-Fr, IHC-P, IF, KD
Applications: WB, Flow, IHC, Block, CyTOF-ready, ELISA(Cap), ELISA(Det), ELISA(Sta)
Species: Hu, Mu
Applications: WB, Flow, IHC, IHC-P
Species: Hu, Mu
Applications: WB, IHC
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Flow-IC
Species: Hu, Po
Applications: Flow, IHC, IHC-Fr, IF
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP, KO
Species: Hu, Mu, Rt, Ca, Rb
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Mu, Rt
Applications: Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Cell Depl, CyTOF-ready, InhibTFunc
Applications: WB, AgAct
Applications: Flow, CyTOF-ready, Neut
Species: Hu, Mu, Rt, Po, Bv, Eq
Applications: WB, ICC/IF, IHC
Applications: Flow, Func, ICC/IF, IHC, IHC-Fr, IHC-P
Publications for PD-L2/B7-DC/PDCD1LG2 Antibody (FAB12241U) (0)
There are no publications for PD-L2/B7-DC/PDCD1LG2 Antibody (FAB12241U).
By submitting your publication information earn gift cards and discounts for future purchases.
Reviews for PD-L2/B7-DC/PDCD1LG2 Antibody (FAB12241U) (0)
There are no reviews for PD-L2/B7-DC/PDCD1LG2 Antibody (FAB12241U).
By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
- Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
- Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
FAQs for PD-L2/B7-DC/PDCD1LG2 Antibody (FAB12241U) (0)
Other Available Formats
Additional PD-L2/B7-DC/PDCD1LG2 Products
PTMs for PD-L2/B7-DC/PDCD1LG2 Antibody (FAB12241U)
Learn more about PTMs related to PD-L2/B7-DC/PDCD1LG2 Antibody (FAB12241U).
Blogs on PD-L2/B7-DC/PDCD1LG2