PD-L2/B7-DC/PDCD1LG2 Antibody (18) [Allophycocyanin]

• Reactivity: Hu
• Applications: ELISA
• Clone: 18
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Allophycocyanin

PD-L2/B7-DC/PDCD1LG2 Antibody (18) [Allophycocyanin] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: This antibody was obtained from a rabbit immunized with purified, recombinant Human PD-L2/B7-DC/PDCD1LG2 (Accession#: NP_079515.2; Met 1-Pro 219).
• Specificity: Has cross-reactivity in ELISA with:
  
  Human B7-H2 / ICOSL / CD275
  Mouse CD86 / B7-2 / B70
  Mouse B7-H1 / CD274 / PD-L1
  No cross-reactivity in ELISA with:
  
  Human CD80 / B7-1
  Human CD86 / B7-2 / B70
  Mouse B7-H2 / ICOSL / CD275
• Source: HEK293
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: PDCD1LG2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP2-89391. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Alternate Names for PD-L2/B7-DC/PDCD1LG2 Antibody (18) [Allophycocyanin]

• B7-DC
• bA574F11.2
• Btdc
• Butyrophilin B7-DC
• Butyrophilin-like Protein
• CD273 antigen
• CD273
• CD273PD-1 ligand 2
• MGC142240
• PD-1-ligand 2
• PDCD1L2MGC142238
• PDCD1LG2
• PDL2
• PD-L2
• PDL2B7DC
• PD-L2PDCD1 ligand 2
• programmed cell death 1 ligand 2
• Programmed death ligand 2

Background

B7-DC is also called programmed death ligand 2 (PDL2). It has recently been clustered as CD273. This ligand is a 42 kD member of the immunoglobulin receptor superfamily expressed on a subset of dendritic cells, liver and a small subset of macrophages as well as a few transformed cell lines. B7-DC (CD273) has been reported to be stimulatory on dendritic cells when cross-linked and to inhibit T cell activation upon engaging the PD-1 receptor. B7-DC (CD273) has also been reported to bind to an alternative receptor and to mediate T cell activation through such non-PD1 mediated interactions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PDCD1LG2