PAX8 Antibody (RM436)

Immunohistochemistry: PAX8 Antibody (RM436)[NBP3-18831]Immunohistochemical staining of formalin fixed and paraffin embedded human Kidney tissue section using anti-Paired box protein Pax-8 rabbit monoclonalantibody (Clone RM436) at a 1:400 dilution.

Immunohistochemistry-Paraffin: PAX8 Antibody (RM436) [NBP3-18831] - Immunohistochemical staining of formalin fixed and paraffin embedded human thyroid tissue section using RM436 at a 1:400 dilution.

• Reactivity: Hu
• Applications: IHC
• Clone: RM436
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

PAX8 Antibody (RM436) Summary

• Description: Novus Biologicals Rabbit PAX8 Antibody (RM436) (NBP3-18831) is a recombinant monoclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: A peptide corresponding to the C-terminus of PAX8 (Uniprot # Q06710)
• Source: HEK293
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: PAX8
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:100 - 1:400

Packaging, Storage & Formulations

• Storage: Store at -20C.
• Buffer: 50% Glycerol/PBS, 1% BSA
• Preservative: 0.09% Sodium Azide
• Purity: Protein A purified

Alternate Names for PAX8 Antibody (RM436)

• paired box 8
• paired box gene 8
• paired box protein Pax-8
• paired domain gene 8

Background

PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain, an octapeptide, and a paired-type homeodomain. This family plays critical roles during fetal development and cancer growth. The specific function of the PAX8 is unknown but it may involve kidney cell differentiation, thyroid development, or thyroid dysgenesis. Alternative splicing in the gene by inclusion or exclusion of exons 7 and/or 8 has produced several known products but the biological significance of the variants is unknown. Several other splice variants have been proposed but the full nature of these products has not been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PAX8