PAWR / PAR4 Antibody

Product Discontinued

PAWR / PAR4 Antibody Summary

• Immunogen: Synthetic peptide surrounding amino acid 327 of human Par4.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PAWR
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS, 0.5% BSA and 30% Glycerol
• Preservative: 0.01% Thimerosal
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PAWR / PAR4 Antibody

• Par-4
• PAR4prostate apoptosis response protein 4
• PRKC apoptosis WT1 regulator protein
• PRKC, apoptosis, WT1, regulator
• Prostate apoptosis response 4 protein
• prostate apoptosis response protein PAR-4
• transcriptional repressor PAR4
• WT1-interacting protein

Background

Prostate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. Par4 is a WT1 interacting protein that also functions as a transcriptional repressor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Bioinformatics

• Gene Symbol: PAWR
• Entrez:
  • 5074(Human)
• Uniprot:
  • EAW97348(Human)