PAR4 Antibody

Immunohistochemistry-Paraffin: PAR4 Antibody [NLS1310] - Anti-F2RL3 / PAR4 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: PAR4 Antibody [NLS1310] - Analysis of anti-F2RL3 / PAR4 antibody with human bone marrow at 2 ug/ml.

Immunohistochemistry-Paraffin: PAR4 Antibody [NLS1310] - Anti-F2RL3 / PAR4 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Product Discontinued

PAR4 Antibody Summary

• Immunogen: Synthetic 16 amino acid peptide from 2nd extracellular domain of human F2RL3 / PAR4.
• Localization: Integral Memebrane Protein
• Specificity: Human F2RL3 / PAR4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Primate (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: F2RL3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 2 - 5 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (94%), Gibbon (94%), Marmoset (81%), Mouse (81%), Canine (81%), Bovine (81%), Panda (81%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PAR4 Antibody

• proteinase-activated receptor 4
• coagulation factor II (thrombin) receptor-like 3
• F2RL3
• PAR4
• Protease-Activated Receptor 4
• Thrombin Receptor-like 3

Background

Proteinase-Activated Receptor 4 (PAR4) is a member of the Proteinase-Activated Receptor subfamily. Along with other protease-activated receptors, PAR4 mediates the effects of the enzyme, thrombin which include activation of platelets, leukocytes, endothelial cells, and mesenchymal cells at sites of vascular injury. These cellular responses are triggered through proteolytic activation of the receptors by thrombin. It is believed that PAR3 functions as a cofactor for the cleavage and activation of PAR4. PAR4 expression has been documented in the periphery, primarily in blood platelets.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: F2RL3
• Entrez:
  • 9002(Human)