PALB2 Antibody

Images

 
Western Blot: PALB2 Antibody [NB100-60440] - Detection of Human PALB2 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa and cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit ...read more
Immunohistochemistry: PALB2 Antibody [NB100-60440] - Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti- PALB2 used at a dilution of 1:1,000 (1 ug/ml). Detection: DAB
Western Blot: PALB2 Antibody [NB100-60440] - Detection of Human PALB2 on HeLa whole cell lysate using NB100-60440. PALB2 was also immunoprecipitated by rabbit anti-PALB2 antibody NB100-60439.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml
 

Independent Antibodies

 

Biological Strategies

     

Order Details

PALB2 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 675 and 725 of human partner and localizer of BRCA2 using the numbering given in entry NP_078951.2 (GeneID 79728).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PALB2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:2000-1:10000
  • Immunohistochemistry
  • Immunoprecipitation 2-5 ug/mg lysate
Positive Control
PALB2 Lysate (NBL1-14086)
Publications
Read Publication using
NB100-60440 in the following applications:

  • IP
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PALB2 Antibody

  • DKFZp667I166
  • DKFZp686E1054
  • FANCNFLJ21816
  • partner and localizer of BRCA2
  • PNCA3

Background

PALB2 (partner and localizer of BRCA2) interacts with BRCA2 and promotes BRCA2 localization and stability. PALB2 is also known as FANCN. Bi-allelic mutations in PALB2 result in Fanconi anemia disorder and breast cancer susceptibility. At the cellular level, PALB2 is important to the DNA damage response and chromosome stability and is essential to BRCA2 function.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PALB2 Antibody (NB100-60440)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IP.


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IP
(1)
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(1)
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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for PALB2 Antibody (NB100-60440) (0)

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for PALB2 Antibody (NB100-60440)

Discover related pathways, diseases and genes to PALB2 Antibody (NB100-60440). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Blogs on PALB2.

The recent relationship of BRCA1 and 53BP1
The p53-binding protein 1 (53BP1) is a DNA damage response factor, which is recruited to nuclear structures at the site of DNA damage.  DNA double-strand breaks (DSBs) are mutations that are detrimental to cell viability and genome stability, and m...  Read full blog post.

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Bioinformatics

Gene Symbol PALB2
Entrez
Uniprot