p130 [p Thr986] Antibody (24GB970)

• Reactivity: Hu, Mu, Rt
• Applications: WB, Flow, ICC/IF
• Clone: 24GB970
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

p130 [p Thr986] Antibody (24GB970) Summary

• Immunogen: A synthesized peptide derived from human Phospho-p130(T986) (Uniprot: Q08999)
• Modification: p Thr986
• Specificity: This antibody detects endogenous levels of RBL2 only when phosphorylated at T986
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: RBL2
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4), 50% glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for p130 [p Thr986] Antibody (24GB970)

• FLJ26459
• P130
• PRB2
• Rb2
• RBR-2
• retinoblastoma-like 2 (p130)
• retinoblastoma-like protein 2,130 kDa retinoblastoma-associated protein
• Retinoblastoma-related protein 2

Background

Two retinoblastoma related proteins, p107 and pRb2 / p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb / p105), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the "pocket domain." Like pRb, both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2 / p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RBL2