ORC1 Antibody (ORC1 7F6/1) [Alexa Fluor™ Plus 680]

Product Discontinued

ORC1 Antibody (ORC1 7F6/1) [Alexa Fluor™ Plus 680] Summary

• Immunogen: Bacterially expressed Human ORC1
• Localization: Nuclear.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: ORC1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for ORC1 Antibody (ORC1 7F6/1) [Alexa Fluor™ Plus 680]

• HS
• HSORC1
• ORC1Lorigin recognition complex subunit 1
• origin recognition complex, subunit 1 (yeast homolog)-like
• origin recognition complex, subunit 1 homolog (S. cerevisiae)
• origin recognition complex, subunit 1 homolog
• origin recognition complex, subunit 1
• origin recognition complex, subunit 1-like (yeast)
• origin recognition complex, subunit 1-like
• PARC1origin recognition complex 1
• Replication control protein 1

Background

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ORC1