Orai2 Antibody Blocking Peptide

• Reactivity: Hu
• Applications: AC
• Concentration: 0.2 mg/ml

Orai2 Antibody Blocking Peptide Summary

• Description: A blocking peptide containing 15 amino acids near the carboxy terminus of human ORAI2.

  Source: Synthetic

  (Accession #: Q96SN7)

• Source: Synthetic
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: ORAI2
• Purity: N/A

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NBP1-77283.
  
  For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin.
• Preservative: 0.02% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: N/A

Alternate Names for Orai2 Antibody Blocking Peptide

• C7orf19
• CAP-binding protein complex interacting protein 2
• CAP-binding protein complex-interacting protein 2
• CBCIP2
• CBCIP2C7orf19FLJ12474
• chromosome 7 open reading frame 19
• FLJ14733
• H_NH0514P08.8
• MEM142B
• ORAI calcium release-activated calcium modulator 2
• Orai2
• PP1729
• protein orai-2
• putative protein ORAI2-2
• TMEM142B
• Transmembrane protein 142BFLJ44818

Background

STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry(SOCE). SOCE allows rapid Ca2+ efflux from the endoplasmic reticulum (ER), following the emptying of intracellularCa2+ stores. STIM (sensors stromal interaction molecule) proteins, STIM1 and STIM2, serve as ER Ca2+ sensors. Theycontain N'-terminal Ca2+-sensing EF-hand domains and are localized to the tubular ER. Following Ca2+ store depletion,STIMs rapidly cluster and relocalize to the plasma membrane-adjacent ER regions, where they oligomerize and form'puncta'. Orai proteins, Orai1, Orai2 and Orai3, are STIM binding partners that form the pore of the channel. Oraiproteins are uniformly distributed in the plasma membrane and exist as dimers in the resting state. STIM activationinduces tetramerization of Orai proteins and subsequent STIM-Orai colocalization, which forms the activestore-operated calcium channel

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: ORAI2