Orai2 Products

Antibodies
Orai2 Antibody
Orai2 Antibody
NBP1-77283
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IF
Host: Rabbit Polyclonal
Orai2 Antibody
Orai2 Antibody
NBP2-19630
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Orai2 Antibody
Orai2 Antibody
NBP2-39064
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Orai2 Overexpression Lysate ( ...
Orai2 Overexpression Lysate (Native)
NBP2-05967
Applications: WB
Orai2 Overexpression Lysate ( ...
Orai2 Overexpression Lysate (Native)
NBP2-09425
Applications: WB
Proteins
Orai2 Recombinant Protein
Orai2 Recombinant Protein
H00080228-P01
Species: Hu
Applications: WB, ELISA, PA
Orai2 Recombinant Protein Ant ...
Orai2 Recombinant Protein Antigen
NBP2-39064PEP
Species: Hu
Applications: AC
Orai2 Peptide
Orai2 Peptide
NBP1-77283PEP
Species: Hu
Applications: AC

Description

STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry(SOCE). SOCE allows rapid Ca2+ efflux from the endoplasmic reticulum (ER), following the emptying of intracellularCa2+ stores. STIM (sensors stromal interaction molecule) proteins, STIM1 and STIM2, serve as ER Ca2+ sensors. Theycontain N'-terminal Ca2+-sensing EF-hand domains and are localized to the tubular ER. Following Ca2+ store depletion,STIMs rapidly cluster and relocalize to the plasma membrane-adjacent ER regions, where they oligomerize and form'puncta'. Orai proteins, Orai1, Orai2 and Orai3, are STIM binding partners that form the pore of the channel. Oraiproteins are uniformly distributed in the plasma membrane and exist as dimers in the resting state. STIM activationinduces tetramerization of Orai proteins and subsequent STIM-Orai colocalization, which forms the activestore-operated calcium channel

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 80228
Alternate Names
  • MEM142B
  • putative protein ORAI2-2
  • CAP-binding protein complex-interacting protein 2
  • protein orai-2
  • TMEM142B
  • CAP-binding protein complex interacting protein 2
  • H_NH0514P08.8
  • FLJ14733
  • CBCIP2C7orf19FLJ12474
  • Transmembrane protein 142BFLJ44818
  • chromosome 7 open reading frame 19
  • ORAI calcium release-activated calcium modulator 2

PTMs for Orai2

Learn more about PTMs related to Orai2.

Methylation

Bioinformatics Tool for Orai2

Discover related pathways, diseases and genes to Orai2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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