Orai1 Antibody

Images

 
Western Blot: Orai1 Antibody [NBP1-77289] - Human ovary tissue lysate with ORAI1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
Immunohistochemistry: Orai1 Antibody [NBP1-77289] - Analysis of ORAI1 in human ovary tissue with ORAI1 antibody at 2.5 ug/ml.
Immunohistochemistry-Paraffin: Orai1 Antibody [NBP1-77289] - Human spleen tissue with ORAI1 antibody at 2.5 ug/ml.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Orai1 Antibody Summary

Immunogen
Antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ORAI1. The immunogen is located within the last 50 amino acids of ORAI1.
Specificity
This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ORAI1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 0.5-1 ug/ml
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Control Peptide
Orai1 Peptide (NBP1-77289PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Orai1 Antibody

  • CRACM1
  • CRACM1ORAT1
  • FLJ14466
  • ORAI calcium release-activated calcium modulator 1
  • Orai1
  • ORAT1
  • Protein orai-1
  • TMEM142A
  • TMEM142Acalcium release-activated calcium modulator 1
  • Transmembrane protein 142Acalcium release-activated calcium channel protein 1

Background

Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ORAI1
Entrez
Uniprot