NT-3 Antibody

Product Discontinued

NT-3 Antibody Summary

• Immunogen: Peptide with sequence C-TSRRKRYAEHKSH corresponding to internal region according to NP_001096124.1, NP_002518.1.
• Epitope: C terminus
• Specificity: This antibody is expected to recognise both isoforms (NP_001096124.1; NP_002518.1)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: NTF3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:1000
• Application Notes: WB: Preliminary experiments in human brain (cerebellum and hippocampus) lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for NT-3 Antibody

• HDNF
• MGC129711
• Nerve growth factor 2
• Neurotrophic factor
• neurotrophin 3
• neurotrophin-3
• NGF2
• NGF-2
• NT3
• NT-3
• NTF3

Background

The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for NT-3 Antibody (NBP1-20950)(1)

Publication using NBP1-20950

• Walz JC, Andreazza AC, Frey BN et al. Serum neurotrophin-3 is increased during manic and depressive episodes in bipolar disorder. Neurosci Lett 2007-03-19 [PMID: 17234344]

Bioinformatics

• Gene Symbol: NTF3
• Entrez:
  • 4908(Human)
• Uniprot:
  • NP_001096124.1(Human)