Notch-4 Antibody

Product Discontinued

Notch-4 Antibody Summary

• Immunogen: Amino acids 1984-2012 of the human NOTCH homolog 4 (NOTCH4) protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NOTCH4
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA 1:32000
• Application Notes: Researchers have indicated that they want access to novel target antibodies quickly to aid in their research. IMGENEX is pleased to be able to offer researchers access to cutting-edge products that are still in the process of characterization/validation. IMGENEX's 'IMX' antibody line is shown by ELISA to bind to the peptide used as immunogen. Investigators should empirically determine the suitability of the antibody, including optimal dilutions, for other applications of interest. We cannot guarantee that the yet-to-be-fully validated antibody will work in any application other than in an ELISA against the peptide used as immunogen and therefore cannot offer a refund if the antibody does not work in your application. The antibody is offered at a lower price compared to a more highly validated antibody. We are not able to provide the immunogen for the antibodies, but do provide the amino acid sequence. These antibodies are not fully validated and we appreciate your feedback. Customer feedback is used to help generate testing methodologies which can lead to further product validation or withdrawal.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 0.1 mg/ml
• Purity: Protein G purified

Alternate Names for Notch-4 Antibody

• INT3
• neurogenic locus notch homolog protein 4
• notch 4
• Notch homolog 4
• NOTCH3
• Notch4
• Notch-4

Background

NOTCH4 encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases (entrez gene).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NOTCH4