NMDAR2B Antibody (S59-20) Summary
Fusion protein amino acids 20-271 (N-terminus) of rat NR2B
Cell Membrane, Cell Junction, Synapse, Postsynaptic Cell Membrane
Detects approx 166kDa. No cross-reactivity against NR2A.
Protein G purified
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- Western Blot 1-10 ug/ml
- Immunocytochemistry/Immunofluorescence 1:100
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Paraffin 0.1-1.0 ug/ml
- Immunoprecipitation 1:10-1:500
1 ug/ml of GluN2B/NR2B Antibody was sufficient for detection of NR2B/GluN2B in 10 ug of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary Antibody.
Based on homology, It's predicted to detect Human and Mouse.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.4) and 50% Glycerol
0.09% Sodium Azide
Protein G purified
Alternate Names for NMDAR2B Antibody (S59-20)
- glutamate [NMDA] receptor subunit epsilon-2
- glutamate receptor subunit epsilon-2
- glutamate receptor, ionotropic, N-methyl D-aspartate 2B
- N-methyl D-aspartate receptor subtype 2B
- N-methyl-D-aspartate receptor subunit 3
NMDA receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long term potentiation, an activity dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA).Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage dependent Mg2+ blockade and high Ca2+ permeability. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer's disease and also epilepsy and ischemic neuronal cell death.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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