NMDAR2B Antibody (13A11)

Product Discontinued

NMDAR2B Antibody (13A11) Summary

• Immunogen: Amino acid region 1033-1161 from human NMDAR2B produced as a GST fusion protein.
• Specificity: NMDAR2B.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: GRIN2B
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Western Blot 1:100-1:2000
• Application Notes: Immunohistochemistry (light and EM) on 4% paraformaldehyde & 0.125% glutaraldehyde fixed tissue: 2.5-5 ug/mL. Immunocytochemistry/Immunofluorescence : 2.5-5.0 ug/mL Western Blot: 1-5 ug/mL

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Concentration: 0.5 mg/ml
• Purity: Protein A or G purified

Notes

Relevant Entrez Gene Numbers: NM_000834.2

Alternate Names for NMDAR2B Antibody (13A11)

• glutamate [NMDA] receptor subunit epsilon-2
• glutamate receptor subunit epsilon-2
• glutamate receptor, ionotropic, N-methyl D-aspartate 2B
• hNR3
• MGC142180
• NMDAR2BMGC142178
• N-methyl D-aspartate receptor subtype 2B
• N-methyl-D-aspartate receptor subunit 3
• NR2B
• NR3

Background

NMDA receptor 2B is an ion channels activated by glutamate. NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors like NMDAR2B also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GRIN2B
• Uniprot:
  • Q13224(Human)