NKp30/NCR3 Antibody (210845) [Unconjugated]


Human NKp30 Monoclonal Antibody induces IFN‑ gamma secretion in the NK-92 human natural killer lymphoma cell line in a dose-dependent manner, as measured using the Quantikine Human IFN‑ gamma ELISA Kit (Catalog # ...read more

Product Details

Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready, Func

Order Details

NKp30/NCR3 Antibody (210845) [Unconjugated] Summary

Additional Information
Clone 210845 was used by HLDA to establish CD designation
Mouse T cell hybridoma transfected with human NKp30/NCR3 and Mouse myeloma cell line NS0-derived recombinant human NKp30 Fc Chimera
Detects human NKp30/NCR3 on cell transfectants and peripheral blood NK cells.
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Agonist Activity 0.2-1.2 ug/mL
  • CyTOF-ready
  • Flow Cytometry 0.25 ug/10^6 cells
Read Publications using
MAB1849 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NKp30/NCR3 Antibody (210845) [Unconjugated]

  • Activating natural killer receptor p30
  • CD337 antigen
  • CD337
  • CD337activating NK-A1 receptor
  • LY117,1C7NK-p30
  • lymphocyte antigen 117
  • natural cytotoxicity triggering receptor 3
  • Natural killer cell p30-related protein
  • NCR3
  • NKp30
  • NKp30MALS


NKp30, along with NKp44 and NKp46, constitute a group of receptors termed “Natural Cytotoxicity Receptors” (1). These receptors play a major role in triggering NK‑mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain (2). A physical association with the ITAM-bearing accessory protein, CD3 zeta , occurs via a charged residue in the NKp30 transmembrane domain. Ligation of NKp30 with a specific antibody results in phosphorylation of CD3 zeta (3). NKp30 is expressed on both resting and activated NK cells of the CD56dim, CD16+ subset that account for more that 85% of NK cells found in peripheral blood and spleen (4). NKp30 is absent from the CD56bright, CD16- subset that constitutes the majority of NK cells in lymph node and tonsil, however, its expression is up-regulated in these cells upon IL-2 activation (4). Studies with neutralizing antibodies reveal that NKp30 is partially responsible for triggering lytic activity against several tumor cell types and that it is the main receptor responsible for NK‑mediated lysis of immature dendritic cells (2, 5). The ligand(s) recognized by NKp30 has not been described.

  1. Moretta, L. and A. Moretta (2004) EMBO J. 23:255.
  2. Pende, D. et al. (1999) J. Exp. Med. 190:1505.
  3. Augugliaro, R. et al. (2003) Eur. J. Immunol. 33:1235.
  4. Ferlazzo, G. et al. (2004) J. Immunol. 172:1455.
  5. Ferlazzo, G. et al. (2002) J. Exp. Med. 195:343.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Mu
Applications: AgAct, CyTOF-ready, Flow, IHC, WB
Species: Hu
Applications: BA
Species: Hu
Applications: CostimT, CyTOF-ready, Flow, Neut, WB
Species: Hu
Applications: BA
Species: Hu, Rt
Applications: Flow-CS, Flow, ICC/IF, IHC, IHC-P, Simple Western
Species: Hu
Applications: Block, WB
Species: Hu
Applications: BA
Species: Hu
Applications: CyTOF-ready, ELISA, Flow, ICC/IF, IHC, IHC-P, PA, WB
Species: Hu, Mu
Applications: Flow-IC, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB
Species: Hu
Applications: Bind
Species: Hu
Applications: CyTOF-ready, Flow
Species: Hu
Applications: Block, CyTOF-ready, Flow
Species: Hu
Applications: BA
Species: Hu
Applications: CyTOF-ready, Flow, Neut, WB
Species: Hu
Applications: Block, CyTOF-reported, Flow
Species: Hu
Applications: BA
Species: Hu, Mu
Applications: ICC/IF, IHC, IHC-Fr, IHC-P, WB
Species: Hu
Applications: Flow, CyTOF-ready, Func

Publications for NKp30/NCR3 Antibody (MAB1849)(6)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Epitope Mapping, Flow Cytometry, Neutralization.

Filter By Application
Epitope Mapping
Flow Cytometry
All Applications
Filter By Species
All Species
Showing Publications 1 - 6 of 6.
Publications using MAB1849 Applications Species
N Kim, MY Kim, YU Cho, W Chen, KH Lee, HS Kim PVR and ICAM-1 on Blast Crisis CML Stem and Progenitor Cells with TKI Resistance Confer Susceptibility to NK Cells Cancers (Basel), 2020;12(7):. 2020 [PMID: 32708713] (Flow Cytometry, Human) Flow Cytometry Human
Z Djaoud, LA Guethlein, A Horowitz, T Azzi, N Nemat-Gorg, D Olive, D Nadal, PJ Norman, C Münz, P Parham Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and ?? T cells J. Exp. Med., 2017;0(0):. 2017 [PMID: 28468758] (Neutralization, Human) Neutralization Human
Herrmann , Julia, Berberich , Hannah, Hartmann , Jessica, Beyer , Steffen, Davies , Karen, Koch , Joachim Homo-oligomerization of the activating natural killer cell receptor NKp30 ectodomain increases its binding affinity for cellular ligands. J Biol Chem, 2014;289(2):765-77. 2014 [PMID: 24275655] (Flow Cytometry, Human) Flow Cytometry Human
Shi J, Tricot GJ, Garg TK, Malaviarachchi PA, Szmania SM, Kellum RE, Storrie B, Mulder A, Shaughnessy JD, Barlogie B, van Rhee F Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma. Blood, 2007;111(3):1309-17. 2007 [PMID: 17947507] (Neutralization, Human) Neutralization Human
Warren HS, Warren&lt;/LastName&gt;&lt;ForeNam HS&lt;/Initia, Bettadapura J A novel binding assay to assess specificity of monoclonal antibodies. J. Immunol. Methods, 2005;305(1):33-8. 2005 [PMID: 16125193] (Epitope Mapping, Human) Epitope Mapping Human
Warren HS, Jones AL, Freeman C, Bettadapura J, Parish CR Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan. J. Immunol., 2005;175(1):207-12. 2005 [PMID: 15972650] (Flow Cytometry, Human) Flow Cytometry Human

Reviews for NKp30/NCR3 Antibody (MAB1849) (0)

There are no reviews for NKp30/NCR3 Antibody (MAB1849). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for NKp30/NCR3 Antibody (MAB1849) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB1849U
Alexa Fluor 405 FAB1849V
Alexa Fluor 488 FAB1849G
Alexa Fluor 488 FAB1849G
Alexa Fluor 532 FAB1849X
Alexa Fluor 594 FAB1849T
Alexa Fluor 647 FAB1849R
Alexa Fluor 700 FAB1849N
Alexa Fluor 750 FAB1849S
Allophycocyanin FAB1849A
Allophycocyanin FAB1849A
Biotin FAB1849B
DyLight 350 FAB1849D
DyLight 405 FAB1849E
DyLight 488 FAB1849K
DyLight 550 FAB1849L
DyLight 594 FAB1849M
DyLight 650 FAB1849W
DyLight 680 FAB1849Y
DyLight 755 FAB1849Z
Janelia Fluor 549 FAB1849I
Janelia Fluor 646 FAB1849J
PerCP FAB1849C
Phycoerythrin FAB1849P
Phycoerythrin FAB1849P

Additional NKp30/NCR3 Products

Bioinformatics Tool for NKp30/NCR3 Antibody (MAB1849)

Discover related pathways, diseases and genes to NKp30/NCR3 Antibody (MAB1849). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for NKp30/NCR3 Antibody (MAB1849)

Discover more about diseases related to NKp30/NCR3 Antibody (MAB1849).

Pathways for NKp30/NCR3 Antibody (MAB1849)

View related products by pathway.

PTMs for NKp30/NCR3 Antibody (MAB1849)

Learn more about PTMs related to NKp30/NCR3 Antibody (MAB1849).

Blogs on NKp30/NCR3

There are no specific blogs for NKp30/NCR3, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Download our Western Blot eHandbook

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our NKp30/NCR3 Antibody (210845) [Unconjugated] and receive a gift card or discount.


Gene Symbol NCR3