NKp30/NCR3 Antibody (210845) [Alexa Fluor® 700]

Images

 
There are currently no images for NKp30/NCR3 Antibody (FAB1849N).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
210845
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 700
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

NKp30/NCR3 Antibody (210845) [Alexa Fluor® 700] Summary

Additional Information
Clone 210845 was used by HLDA to establish CD designation
Immunogen
Mouse T cell hybridoma transfected with human NKp30/NCR3 and Mouse myeloma cell line NS0-derived recombinant human NKp30 Fc Chimera
Specificity
Detects human NKp30/NCR3 on cell transfectants and peripheral blood NK cells.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
NCR3
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Preservative
0.09% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NKp30/NCR3 Antibody (210845) [Alexa Fluor® 700]

  • Activating natural killer receptor p30
  • CD337 antigen
  • CD337
  • CD337activating NK-A1 receptor
  • LY117,1C7NK-p30
  • lymphocyte antigen 117
  • natural cytotoxicity triggering receptor 3
  • Natural killer cell p30-related protein
  • NCR3
  • NKp30
  • NKp30MALS

Background

NKp30, along with NKp44 and NKp46, constitute a group of receptors termed “Natural Cytotoxicity Receptors” (1). These receptors play a major role in triggering NK‑mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain (2). A physical association with the ITAM-bearing accessory protein, CD3 zeta, occurs via a charged residue in the NKp30 transmembrane domain. Ligation of NKp30 with a specific antibody results in phosphorylation of CD3 zeta (3). NKp30 is expressed on both resting and activated NK cells of the CD56dim, CD16+ subset that account for more that 85% of NK cells found in peripheral blood and spleen (4). NKp30 is absent from the CD56bright, CD16- subset that constitutes the majority of NK cells in lymph node and tonsil, however, its expression is up-regulated in these cells upon IL-2 activation (4). Studies with neutralizing antibodies reveal that NKp30 is partially responsible for triggering lytic activity against several tumor cell types and that it is the main receptor responsible for NK‑mediated lysis of immature dendritic cells (2, 5). The ligand(s) recognized by NKp30 has not been described.

  1. Moretta, L. and A. Moretta (2004) EMBO J. 23:255.
  2. Pende, D. et al. (1999) J. Exp. Med. 190:1505.
  3. Augugliaro, R. et al. (2003) Eur. J. Immunol. 33:1235.
  4. Ferlazzo, G. et al. (2004) J. Immunol. 172:1455.
  5. Ferlazzo, G. et al. (2002) J. Exp. Med. 195:343.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

AF2225
Species: Mu
Applications: WB, Flow, IHC, AgAct, CyTOF-ready
2249-NK
Species: Hu
MAB139
Species: Hu
Applications: WB, Flow, CostimT, CyTOF-ready, Neut
NBP2-15184
Species: Hu, Rt, Ze
Applications: WB, Simple Western, ELISA, Flow, ICC/IF, IHC-Fr, IHC-P, IP, PAGE
MAB2546
Species: Hu
Applications: Flow, CyTOF-ready
AF-386-PB
Species: Hu
Applications: WB, Flow, CyTOF-ready, ICC
NBP1-84550
Species: Hu
Applications: WB, IHC, IHC-P
NB100-524
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Flow-IC
NBP1-27946
Species: Mu
Applications: B/N, Flow, IHC-Fr, IP
MAB1059
Species: Hu
Applications: Flow, CyTOF-ready
MAB1058
Species: Hu
Applications: Flow, Block, CyTOF-ready
MAB666
Species: Hu
Applications: WB, Flow, CyTOF-ready, Neut
MAB12251
Species: Hu
Applications: Flow, CyTOF-ready
NBP1-58906
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
FAB1849N
Species: Hu
Applications: Flow

Publications for NKp30/NCR3 Antibody (FAB1849N) (0)

There are no publications for NKp30/NCR3 Antibody (FAB1849N).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for NKp30/NCR3 Antibody (FAB1849N) (0)

There are no reviews for NKp30/NCR3 Antibody (FAB1849N). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for NKp30/NCR3 Antibody (FAB1849N) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Array Products

Bioinformatics Tool for NKp30/NCR3 Antibody (FAB1849N)

Discover related pathways, diseases and genes to NKp30/NCR3 Antibody (FAB1849N). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for NKp30/NCR3 Antibody (FAB1849N)

Discover more about diseases related to NKp30/NCR3 Antibody (FAB1849N).
 

Pathways for NKp30/NCR3 Antibody (FAB1849N)

View related products by pathway.

PTMs for NKp30/NCR3 Antibody (FAB1849N)

Learn more about PTMs related to NKp30/NCR3 Antibody (FAB1849N).

Blogs on NKp30/NCR3

There are no specific blogs for NKp30/NCR3, but you can read our latest blog posts.

Customers Who Bought This Also Bought

NKp30/NCR3
1849-NK-025

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our NKp30/NCR3 Antibody (210845) [Alexa Fluor® 700] and receive a gift card or discount.

Bioinformatics

Gene Symbol NCR3
Entrez