NKG2A/CD159a/KLRC1 Antibody (2097C) [Alexa Fluor™ Plus 647]

• Reactivity: Mu
• Clone: 2097C
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor Plus 647

NKG2A/CD159a/KLRC1 Antibody (2097C) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects mouse NKG2A/CD159a in direct ELISAs. In Flow Cytometry, no cross-reactivity with mouse NKG2C/CD159c is observed.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NKG2A/CD159a/KLRC1 Antibody (2097C) [Alexa Fluor™ Plus 647]

• CD159 antigen-like family member A
• CD159a antigen
• CD159a
• C-lectin type II protein
• killer cell lectin-like receptor subfamily C, member 1
• Klrc1
• MGC13374
• natural killer cell lectin
• natural killer group protein 2
• NK cell receptor A
• NKG2
• NKG2-1/B activating NK receptor
• NKG2A
• NKG2-A
• NKG2-A/B type II integral membrane protein
• NKG2-A/B-activating NK receptor
• NKG2-A/NKG2-B type II integral membrane protein
• NKG2AMGC59791
• NKG2-B

Background

NKG2A, also known as CD159a, is a 244 amino acid (aa), ~38 kDa type II transmembrane glycoprotein with a cytoplasmic ITIM motif and a single extracellular lectin-like domain. Within the extracellular domain (aa 94-244), mouse NKG2A shares 71% and 41% aa sequence identity with rat and human NKG2A, respectively. An isoform lacking aa 98-114 has been described. NKG2A associates with CD94 and is coexpressed on NK cells and some activated T cell populations. The NKG2A/CD94 complex delivers an inhibitory signal upon recognition of its murine ligand, Qa-1b (or HLA-E in humans) on antigen presenting cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.