NFATC3/NFAT4 Antibody [Alexa Fluor™ Plus 647]

• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 647

NFATC3/NFAT4 Antibody [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human NFATC3 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NFATC3/NFAT4 Antibody [Alexa Fluor™ Plus 647]

• NFAT4
• NF-AT4
• NFAT4nuclear factor of activated T-cells, cytoplasmic 3
• NFATC3
• NF-ATc3
• NFATX
• nuclear factor of activated T-cells c3 isoform IE-Xa
• nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
• T cell transcription factor NFAT4
• T-cell transcription factor NFAT4

Background

NFATC3 (Nuclear factor of activated T cells C3; also NFAT4 and NFATx) is a 145‑150 kDa member of the NFAT family of transcription factors. NFATC3 is widely expressed being found in DP thymocytes, CD4+ T cells, smooth muscle cells, Schwann cells and mast cells. NFATC3 regulates gene transcription as part of a NFATC transcription complex. It is normally cytoplasmic and phosphorylated. Upon a rise in intracellular Ca⁺², dephosphorylation occurs via calcineurin, and NFATC3 enters the nucleus. Human NFATC3 is 1075 amino acids (aa) in length. It contains a calcineurin binding site (aa 109‑114), two nuclear localization sites (aa 273‑275 and 686‑688), one nuclear export site (aa 1032‑1041) and an RH domain that binds DNA (aa 433‑592). There are multiple isoforms with different tissue expression profiles. Over aa 900‑1035, human NFATC3 shares 93% aa identity with mouse NFATC3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.