NEU-1/Sialidase-1 Antibody

Western Blot: NEU-1/Sialidase-1 Antibody [H00004758-B02P-50ug] - Analysis of NEU1 expression in transfected 293T cell line (H00004758-T03) by NEU1 MaxPab polyclonal antibody. Lane 1: NEU1 transfected lysate(45.65 KDa). Lane 2: Non-transfected lysate.

Product Discontinued

NEU-1/Sialidase-1 Antibody Summary

• Immunogen: NEU1 (ABM86306.1, 1 a.a. - 415 a.a.) full-length human protein. MTGERPSTALPDRRWGPRILGFWGGCRVWVFAAIFLLLSLAASWSKAENDFGLVQPLVTMEQLLWVSGRQIGSVDTFRIPLITATPRGTLLAFAEARKMSSSDEGAKFIALRRSMDQGSTWSPTAFIVNDGDVPDGLNLGAVVSDVETGVVFLFYSLCAHKAGCQVASTMLVWSKDDGVSWSTPRNLSLDIGTEVFAPGPGSGIQKQREPRKGRLIVCGHGTLERDGVFCLLSDDHGASWRYGSGVSGIPYGQPKQENDFNPDECQPYELPDGSVVINARNQNNYHCHCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGAVVTSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWRKETVQLWPGPSGYSSLATLEGSMDGEEQAPQLYVLYEKGRNHYTESISVAKISVYGTL
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: NEU1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for NEU-1/Sialidase-1 Antibody

• Acetylneuraminyl hydrolase
• EC 3.2.1.18
• exo-alpha-sialidase
• FLJ93471
• G9 sialidase
• Lysosomal sialidase
• N-acetyl-alpha-neuraminidase 1
• NANH
• NEU
• NEU1
• NEU-1
• SIAL1
• sialidase 1 (lysosomal sialidase)
• Sialidase-1

Background

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Neu, a glycoprotein, undergoes transactivation upon heterodimerization with other EGF receptor family members. Neu heterodimerization with ErbB-3 recruits heregulin, which induces phosphoinositide (PI) 3-kinase activation. Activation of Neu potentiates tumor cell motility and protease secretion and invasion, and also modulates cell cycle checkpoint function, DNA repair and apoptotic responses. Amplification and/or overexpression of Neu occurs in 20-30% of breast carcinomas. Measurement of increased Neu expression can be a predictor of disease prognosis. Neu may also prove to be a promising target for therapeutic agents.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NEU1
• Entrez:
  • 4758(Human)
• OMIM:
  • 256550(Human)
• Uniprot:
  • ABM86306.1(Human)