Species: Hu
Applications: WB, IP
Host: Mouse Monoclonal
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Neu, a glycoprotein, undergoes transactivation upon heterodimerization with other EGF receptor family members. Neu heterodimerization with ErbB-3 recruits heregulin, which induces phosphoinositide (PI) 3-kinase activation. Activation of Neu potentiates tumor cell motility and protease secretion and invasion, and also modulates cell cycle checkpoint function, DNA repair and apoptotic responses. Amplification and/or overexpression of Neu occurs in 20-30% of breast carcinomas. Measurement of increased Neu expression can be a predictor of disease prognosis. Neu may also prove to be a promising target for therapeutic agents.
Bioinformatics
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
4758 |
| Alternate Names |
- Acetylneuraminyl hydrolase
- EC 3.2.1.18
- exo-alpha-sialidase
- FLJ93471
- G9 sialidase
- Lysosomal sialidase
- N-acetyl-alpha-neuraminidase 1
- NANH
- NEU
- SIAL1
- sialidase 1 (lysosomal sialidase)
- sialidase-1
|
