NEU-1/Sialidase-1 Products

Description

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Neu, a glycoprotein, undergoes transactivation upon heterodimerization with other EGF receptor family members. Neu heterodimerization with ErbB-3 recruits heregulin, which induces phosphoinositide (PI) 3-kinase activation. Activation of Neu potentiates tumor cell motility and protease secretion and invasion, and also modulates cell cycle checkpoint function, DNA repair and apoptotic responses. Amplification and/or overexpression of Neu occurs in 20-30% of breast carcinomas. Measurement of increased Neu expression can be a predictor of disease prognosis. Neu may also prove to be a promising target for therapeutic agents.

Bioinformatics

Uniprot	NM_000434 Human NP_000425 Human Q99519 Human
Product By Gene ID	4758
Alternate Names	sialidase-1 N-acetyl-alpha-neuraminidase 1 exo-alpha-sialidase G9 sialidase FLJ93471 NANH SIAL1 Lysosomal sialidase NEU Acetylneuraminyl hydrolase EC 3.2.1.18 sialidase 1 (lysosomal sialidase)

Diseases related to NEU-1/Sialidase-1

Discover more about diseases related to NEU-1/Sialidase-1.

Type I Mucolipidosis
Mucolipidoses
Lysosomal Storage Diseases
Galactosialidosis
Neuraminidase 1 Deficiency
Tissue Adhesions
Storage Disease
Neoplasms
Edema
Hydrops Fetalis
Malignant Neoplasms
Inflammation
Ataxia
Adenocarcinoma
Congenital Abnormality
Atrophy
Neurodegenerative Disorders
Myoclonus
Infertility
Lymphoma

Pathways for NEU-1/Sialidase-1

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Localization
Immune Response
Cell Adhesion
Cell Activation
Cell Proliferation
Glycosylation
Cell Death
Pathogenesis
Transport
Cell Migration
Phagocytosis
Cell Differentiation
Exocytosis
Elastic Fiber Assembly
Cytokine Production
Monocyte Differentiation
Secretion
Response To Lipopolysaccharide
Diapedesis
Programmed Cell Death

PTMs for NEU-1/Sialidase-1

Learn more about PTMs related to NEU-1/Sialidase-1.

Glycosylation
Phosphorylation
Carboxylation
Cleavage
Biotinylation

Bioinformatics Tool for NEU-1/Sialidase-1

Discover related pathways, diseases and genes to NEU-1/Sialidase-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.