NEU-1/Sialidase-1 Products

Antibodies
NEU-1/Sialidase-1 Antibody (3 ...
NEU-1/Sialidase-1 Antibody (3D4)
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
NEU-1/Sialidase-1 Antibody
NEU-1/Sialidase-1 Antibody
NBP1-87755
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
NEU-1/Sialidase-1 Antibody
NEU-1/Sialidase-1 Antibody
NBP1-87756
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Kits
NEU-1/Sialidase-1 Assay Kit
NEU-1/Sialidase-1 Assay Kit
KA1633
Applications: Func
Lysates
NEU-1/Sialidase-1 Overexpress ...
NEU-1/Sialidase-1 Overexpression L...
NBL1-13594
Applications: WB
Proteins
NEU-1/Sialidase-1 Recombinant ...
NEU-1/Sialidase-1 Recombinant Protein
NBP2-23471
Species: Hu
Applications: PAGE
NEU-1/Sialidase-1 Recombinant ...
NEU-1/Sialidase-1 Recombinant Prot...
NBP1-87756PEP
Species: Hu
Applications: AC
NEU-1/Sialidase-1 Recombinant ...
NEU-1/Sialidase-1 Recombinant Prot...
NBP1-87755PEP
Species: Hu
Applications: AC
RNAi
NEU-1/Sialidase-1 RNAi
NEU-1/Sialidase-1 RNAi
H00004758-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Neu, a glycoprotein, undergoes transactivation upon heterodimerization with other EGF receptor family members. Neu heterodimerization with ErbB-3 recruits heregulin, which induces phosphoinositide (PI) 3-kinase activation. Activation of Neu potentiates tumor cell motility and protease secretion and invasion, and also modulates cell cycle checkpoint function, DNA repair and apoptotic responses. Amplification and/or overexpression of Neu occurs in 20-30% of breast carcinomas. Measurement of increased Neu expression can be a predictor of disease prognosis. Neu may also prove to be a promising target for therapeutic agents.

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 4758
Alternate Names
  • sialidase-1
  • N-acetyl-alpha-neuraminidase 1
  • exo-alpha-sialidase
  • G9 sialidase
  • FLJ93471
  • NANH
  • SIAL1
  • Lysosomal sialidase
  • NEU
  • Acetylneuraminyl hydrolase
  • EC 3.2.1.18
  • sialidase 1 (lysosomal sialidase)

PTMs for NEU-1/Sialidase-1

Learn more about PTMs related to NEU-1/Sialidase-1.

Glycosylation
Phosphorylation
Carboxylation
Cleavage
Biotinylation

Bioinformatics Tool for NEU-1/Sialidase-1

Discover related pathways, diseases and genes to NEU-1/Sialidase-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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