Nectin-2/CD112 Antibody (R2.525) - BSA Free

Flow Cytometry: Nectin-2/CD112 Antibody (R2.525) [NBP3-09163] - Separation of human CD112 positive thrombocytes(red-filled) from lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD112 (R2.525) purified antibody (concentration in sample 9 ug/ml) GAM APC.

Flow Cytometry: Nectin-2/CD112 Antibody (R2.525) [NBP3-09163] - surface staining pattern of human peripheral whole blood stained using anti-human CD112 (R2.525) purified antibody (concentration in sample 9 ug/ml) GAM APC

• Reactivity: Hu
• Applications: Flow, IHC, IP
• Clone: R2.525
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

Nectin-2/CD112 Antibody (R2.525) - BSA Free Summary

• Description: Novus Biologicals Mouse Nectin-2/CD112 Antibody (R2.525) - BSA Free (NBP3-09163) is a monoclonal antibody validated for use in IHC, Flow and IP. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Additional Information: Clone R2.525 was used by HLDA to establish CD designation.
• Immunogen: NIH/3T3 cells transfected with human Nectin-2
• Specificity: The mouse monoclonal antibody R2.525 recognizes an extracellular epitope on CD112, a type I transmembrane glycoprotein expressed by myelomonocytic and megakaryocytic cells, and by CD34+ hematopoietic progenitors.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: NECTIN2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1-4 ug/ml
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunoprecipitation

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Phosphate buffered saline (PBS), pH 7.4
• Preservative: 15mM Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for Nectin-2/CD112 Antibody (R2.525) - BSA Free

• CD112 antigen
• CD112
• Herpes virus entry mediator B
• Herpesvirus entry mediator B
• herpesvirus entry protein B
• HVEB
• HVEBpoliovirus receptor-like 2
• MPH
• nectin 2
• Nectin2
• Nectin-2
• poliovirus receptor-related 2 (herpesvirus entry mediator B)
• poliovirus receptor-related protein 2
• PRR2
• PRR2nectin-2
• PVRL2
• PVRR2poliovirus receptor related 2

Background

Nectin 2 encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NECTIN2