Nectin-2/CD112 Antibody (DMC224) - Chimeric

• Reactivity: Hu
• Applications: ELISA, Flow
• Clone: DMC224
• Clonality: Monoclonal
• Host: Human
• Conjugate: Unconjugated
• Concentration: LYOPH

Nectin-2/CD112 Antibody (DMC224) - Chimeric Summary

• Description: This product is shipped at ambient temperature. Store at -20C to -80C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80C (Avoid repeated freezing and thawing).
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: Nectin-2/CD112 recombinant protein expressed in mammalian cells (Accession# Q92692). The exact amino acid sequence is proprietary.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Human
• Gene: NECTIN2
• Purity: Antigen Affinity-purified from cell culture supernatant

Applications/Dilutions

• Dilutions:
  • ELISA 1:5000-10000
  • Flow Cytometry 1:100

Packaging, Storage & Formulations

• Storage: Store at -20C in powder form. Store at -80C once reconstituted.
• Buffer: PBS, pH 7.4, 5-8% Trehalose
• Preservative: Trehalose
• Concentration: LYOPH
• Purity: Antigen Affinity-purified from cell culture supernatant
• Reconstitution Instructions: Dissolve the lyophilized antibody in sterile and low endotoxin water. The recommend volume of water is lot specific. Please refer to the instructions printed on the product vial or contact technical support.

Alternate Names for Nectin-2/CD112 Antibody (DMC224) - Chimeric

• CD112 antigen
• CD112
• Herpes virus entry mediator B
• Herpesvirus entry mediator B
• herpesvirus entry protein B
• HVEB
• HVEBpoliovirus receptor-like 2
• MPH
• nectin 2
• Nectin2
• Nectin-2
• poliovirus receptor-related 2 (herpesvirus entry mediator B)
• poliovirus receptor-related protein 2
• PRR2
• PRR2nectin-2
• PVRL2
• PVRR2poliovirus receptor related 2

Background

Nectin 2 encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NECTIN2