Recombinant Human NDRG1 Protein

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SDS-Page: NDRG1 Protein [NBP1-30231] - NDRG1, 43.9 kDa (402aa), confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Func, PAGE
Concentration
1 mg/ml

Order Details

Recombinant Human NDRG1 Protein Summary

Description
A bioactive recombinant protein with a C-Terminal His-tag and corresponding to the amino acids 1-394 of Human NDRG1

Source: E.coli

Amino Acid Sequence: MSREMQDVDL AEVKPLVEKG ETITGLLQEF DVQEQDIETL HGSVHVTLCG TPKGNRPVIL TYHDIGMNHK TCYNPLFNYE DMQEITQHFA VCHVDAPGQQ DGAASFPAGY MYPSMDQLAE MLPGVLQQFG LKSIIGMGTG AGAYILTRFA LNNPEMVEGL VLINVNPCAE GWMDWAASKI SGWTQALPDM VVSHLFGKEE MQSNVEVVHT YRQHIVNDMN PGNLHLFINA YNSRRDLEIE RPMPGTHTVT LQCPALLVVG DSSPAVDAVV ECNSKLDPTK TTLLKMADCG GLPQISQPAK LAEAFKYFVQ GMGYMPSASM TRLMRSRTAS GSSVTSLDGT RSRSHTSEGT RSRSHTSEGT RSRSHTSEGA HLDITPNSGA AGNSAGPKSM EVSCLEHHHH HH

Details of Functionality
The ED50 for this effect is 0.5 - 1.5 ng/ml. Measured in a cell proliferation assay using MCF7 cell.
Source
E. coli
Protein/Peptide Type
Biologically Active Protein
Gene
NDRG1
Purity
>95% pure by SDS-PAGE

Applications/Dilutions

Theoretical MW
43.9 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20 mM Tris-HCl buffer (pH8.0) containing 0.1 mM PMSF, 10% glycerol
Preservative
No Preservative
Concentration
1 mg/ml
Purity
>95% pure by SDS-PAGE

Alternate Names for Recombinant Human NDRG1 Protein

  • CAP43
  • CMT4D
  • Differentiation-related gene 1 protein
  • DRG1
  • DRG-1
  • DRG1HMSNL
  • GC4
  • HMSNL
  • NDR1
  • NDRG1
  • Nickel-specific induction protein Cap43
  • NMSL
  • N-myc downstream regulated 1
  • N-myc downstream-regulated gene 1 protein
  • protein NDRG1
  • protein regulated by oxygen-1
  • PROXY1
  • Reducing agents and tunicamycin-responsive protein
  • RIT42
  • RTP
  • RTPGC4
  • TARG1
  • TDD5
  • tunicamycin-responsive protein

Background

N-myc downstream regulated gene (NDRG)-1 is one of 4 members of the NDRG alpha/beta-hydrolase family. This protein is classified in databases as a tumor suppressor and heavy metal-response protein. Its functions include cell-cycle regulation, cellular differentiation, apoptosis, hypoxia response and metal-ion sensing. Mutation in the NDRG1 gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom (HMSNL), a severe autosomal recessive form of Charcot-Marie-Tooth (CMT) disease. Recombinant human NDRG1, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 2 years from date of receipt.

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Bioinformatics

Gene Symbol NDRG1
Entrez