Myotilin Antibody (OTI8A7)

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: OTI8A7
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

Myotilin Antibody (OTI8A7) Summary

• Description: Novus Biologicals Mouse Myotilin Antibody (OTI8A7) (NBP3-44772) is a monoclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Full length human recombinant protein of human MYOT (NP_006781) produced in E.coli.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: Myotilin
• Purity: >95%

Applications/Dilutions

• Dilutions:
  • Western Blot 1:2000

Packaging, Storage & Formulations

• Storage: Store at -20 degrees C. Avoid freeze/thaw cycles.
• Buffer: Lyophilized powder ( 1X PBS, pH 7.3,)
• Preservative: 8% Trehalose
• Purity: >95%
• Reconstitution Instructions: For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process.

Alternate Names for Myotilin Antibody (OTI8A7)

• 57 kDa cytoskeletal protein
• LGMD1A
• limb-girdle muscular dystrophy 1A (autosomal dominant)
• Myofibrillar titin-like Ig domains protein
• myotilin
• titin immunoglobulin domain protein (myotilin)
• Titin immunoglobulin domain protein
• TTIDLGMD1

Background

Striated muscle sarcomeres are highly organized structures composed of actin (thin) and myosin (thick) filaments that slide past each other during contraction. The integrity of sarcomeres is controlled by a set of structural proteins, among which are titin (TTN; MIM 188840), a giant molecule that contains several immunoglobulin (Ig)-like domains and associates with thin and thick filaments, and alpha-actinin (ACTN1; MIM 102575), an actin cross-linking protein. Mutations in several sarcomeric and sarcolemmal proteins have been shown to result in muscular dystrophy and cardiomyopathy.[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: Myotilin