Myotilin Products

Description

Striated muscle sarcomeres are highly organized structures composed of actin (thin) and myosin (thick) filaments that slide past each other during contraction. The integrity of sarcomeres is controlled by a set of structural proteins, among which are titin (TTN; MIM 188840), a giant molecule that contains several immunoglobulin (Ig)-like domains and associates with thin and thick filaments, and alpha-actinin (ACTN1; MIM 102575), an actin cross-linking protein. Mutations in several sarcomeric and sarcolemmal proteins have been shown to result in muscular dystrophy and cardiomyopathy.[supplied by OMIM]

Bioinformatics

Uniprot	NM_006790 Human NP_006781.1 Human Q9UBF9 Human
Product By Gene ID	9499
Alternate Names	57 kDa cytoskeletal protein LGMD1A limb-girdle muscular dystrophy 1A (autosomal dominant) Myofibrillar titin-like Ig domains protein myotilin titin immunoglobulin domain protein (myotilin) Titin immunoglobulin domain protein TTIDLGMD1