Myelin PLP Antibody

Images

 
Immunocytochemistry/ Immunofluorescence: Myelin PLP Antibody [NB100-1608] - In this tissue section through an e 13 mouse brain, PLP (green staining) can be seen in immature oligodendrocytes of white matter tracts. DAPI ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Chicken
Conjugate
Unconjugated
Concentration
0.1 mg/ml

Order Details

Myelin PLP Antibody Summary

Immunogen
Chickens were immunized with a peptide / keyhole limpet hemocyanin (KLH) conjugate. The synthetic peptide corresponded to a region shared between the mouse (P60202, NCBI) and human gene products [PLP1 isoform 1 (NP_000524, NCBI), PLP1 isoform 2 (NP_955772, NCBI)]. The sequence can be found between amino acid 26-75. After repeated injections into the hens, immune eggs were collected, and the IgY fractions were purified from the yolks. These IgY fractions were then affinity-purified using a peptide column, the concentration of the eluate adjusted to 100 ug/ml, and the preparation was filter-sterilized.
Marker
Oligodendrocyte Marker
Specificity
Proteolipid Protein
Clonality
Polyclonal
Host
Chicken
Gene
PLP1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:2000-1:5000
  • Immunocytochemistry/Immunofluorescence 1:1000-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
Western Blot reactivity reported in scientific literature (PMID: 24057669).
Publications
Read Publication using
NB100-1608 in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
10mM Sodium PBS (0.9% isotonic, w/v, pH 7.2)
Preservative
0.02% Sodium Azide
Concentration
0.1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Myelin PLP Antibody

  • DM-20
  • HLD1
  • Lipophilin
  • major myelin proteolipid protein
  • MMPL
  • Myelin PLP
  • myelin proteolipid protein
  • PLP
  • PLP/DM20
  • PLP1
  • PMD
  • proteolipid protein 1
  • spastic paraplegia 2, uncomplicated
  • SPG2

Background

Human PLP (also known as lipophilin) is a 30 kDa protein (277 amino acids) found in myelin of the CNS and PNS. Expressed by oligodendrocytes and Schwann cells, PLP stabilizes myelin by preventing lipid bilayer fusion, and aids in compaction. Different mutations of the human PLP gene product result in two neurological disorders - Pelizaeus-Merzbacher disease and Spastic Paraplegia type 2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Myelin PLP Antibody (NB100-1608)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.


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WB
(1)
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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PLP1
Entrez