Myelin PLP Antibody (plpc1)

Immunohistochemistry-Paraffin: APLP-1 Antibody (plpc1) [NBP1-50309] - Analysis of anti-PLP1 antibody with human brain, cortex at concentration 10 ug/ml.

Immunohistochemistry-Paraffin: APLP-1 Antibody (plpc1) [NBP1-50309] - Analysis of anti-PLP1 antibody with human brain, cerebellum at concentration 10 ug/ml.

Product Discontinued

Myelin PLP Antibody (plpc1) Summary

• Immunogen: Synthetic peptide GRGTKF corresponding to C terminal region of myelin proteolipid protein.
• Specificity: Recognizes myelin proteolipid protein (PLP) in many mammalian species. This Recognizes DM20. PLP encodes the major protein components of compact CNS myelin and mutations in the PLP gene can lead to severe dysmyelinating disease
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: PLP1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 10 ug/ml
  • Western Blot 1:100-1:2000

Reactivity Notes

Bovine, Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, from tissue culture supernatant
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein A purified

Alternate Names for Myelin PLP Antibody (plpc1)

• DM-20
• HLD1
• Lipophilin
• major myelin proteolipid protein
• MMPL
• Myelin PLP
• myelin proteolipid protein
• PLP
• PLP/DM20
• PLP1
• PMD
• proteolipid protein 1
• spastic paraplegia 2, uncomplicated
• SPG2

Background

This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PLP1