Myelin PLP Antibody (plpc1)

Images

 
Immunohistochemistry-Paraffin: APLP-1 Antibody (plpc1) [NBP1-50309] - Analysis of anti-PLP1 antibody with human brain, cortex at concentration 10 ug/ml.
Immunohistochemistry-Paraffin: APLP-1 Antibody (plpc1) [NBP1-50309] - Analysis of anti-PLP1 antibody with human brain, cerebellum at concentration 10 ug/ml.

Product Details

Summary
Reactivity Hu, BvSpecies Glossary
Applications WB, IHC-Fr, IHC-P
Clone
plpc1
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Myelin PLP Antibody (plpc1) Summary

Immunogen
Synthetic peptide GRGTKF corresponding to C terminal region of myelin proteolipid protein.
Specificity
Recognizes myelin proteolipid protein (PLP) in many mammalian species. This Recognizes DM20. PLP encodes the major protein components of compact CNS myelin and mutations in the PLP gene can lead to severe dysmyelinating disease
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
PLP1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 10 ug/ml

Reactivity Notes

Bovine, Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, from tissue culture supernatant
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for Myelin PLP Antibody (plpc1)

  • DM-20
  • HLD1
  • Lipophilin
  • major myelin proteolipid protein
  • MMPL
  • Myelin PLP
  • myelin proteolipid protein
  • PLP
  • PLP/DM20
  • PLP1
  • PMD
  • proteolipid protein 1
  • spastic paraplegia 2, uncomplicated
  • SPG2

Background

This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PLP1
Entrez