MRP1 Antibody (464510) [DyLight 650]

• Reactivity: Hu
• Applications: CyTOF-ready, Flow
• Clone: 464510
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 650

MRP1 Antibody (464510) [DyLight 650] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: HEK293 human embryonic kidney cell line transfected with human MPR1
  Met1-Val1531
  Accession # P33527
• Specificity: Detects human MRP1. Detects human MRP1-transfected cells, but not irrelevant transfectants by flow cytometry.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: ABCC1
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Intracellular Staining by Flow Cytometry
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product MAB1929. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for MRP1 Antibody (464510) [DyLight 650]

• ABC29
• ABCC
• ABCC1
• ATP-binding cassette sub-family C member 1
• ATP-binding cassette, sub-family C (CFTR/MRP), member 1
• EC 3.6.3
• EC 3.6.3.44
• GS-X
• Leukotriene C(4) transporter
• LTC4 transporter
• MRP1
• MRP1DKFZp781G125
• MRPDKFZp686N04233
• multidrug resistance associated protein 1
• multidrug resistance protein
• multidrug resistance-associated protein 1
• multiple drug resistance protein 1
• multiple drug resistance-associated protein

Background

Multidrug Resistance Protein 1 (MRP1) is an integral membrane glycophosphoprotein belonging to the same superfamily of ATP-binding cassette transmembrane transporter proteins as P-glycoprotein. MRP1 is overexpressed in many P-glycoprotein-negative, multidrug resistant cell lines and tumours. It is believed that the main function of MRP in drug resistance is that of a plasma membrane drug efflux pump.

Specifically, MRP1 mediates the export of organic anions and drugs from the cytoplasm. It is through this function, that MRP1 is able to confer resistance to anticancer drugs. MRP1 antibodies are therefore useful tools for cancer testing and research.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ABCC1