MRP1 Products

Description

Multidrug Resistance Protein 1 (MRP1) is an integral membrane glycophosphoprotein belonging to the same superfamily of ATP-binding cassette transmembrane transporter proteins as P-glycoprotein. MRP1 is overexpressed in many P-glycoprotein-negative, multidrug resistant cell lines and tumours. It is believed that the main function of MRP in drug resistance is that of a plasma membrane drug efflux pump.

Specifically, MRP1 mediates the export of organic anions and drugs from the cytoplasm. It is through this function, that MRP1 is able to confer resistance to anticancer drugs. MRP1 antibodies are therefore useful tools for cancer testing and research.

Bioinformatics

Entrez	17250 Mouse 24565 Rat 4363 Human
Uniprot	P33527 Human
Product By Gene ID	4363
Alternate Names	ABC29 ABCC ATP-binding cassette sub-family C member 1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 EC 3.6.3 EC 3.6.3.44 GS-X Leukotriene C(4) transporter LTC4 transporter MRP1DKFZp781G125 MRPDKFZp686N04233 multidrug resistance associated protein 1 multidrug resistance protein multidrug resistance-associated protein 1 multiple drug resistance protein 1 multiple drug resistance-associated protein

Research Areas for MRP1

Find related products by research area and learn more about each of the different research areas below.

ABC Transporters
Amino Acids, Drugs and other small molecules
Cancer
Lipid and Metabolism
Plasma Membrane Markers
Signal Transduction

Related MRP1 Blog Posts

Check out the latest blog posts on MRP1.

ABC Membrane transporters and the role of MRP1 in drug resistance ATP-binding cassette (ABC) transporters, alongside ion channels and aquaporins, are ubiquitous membrane-bound proteins that move substrates across extra and intra cellular membranes.  Multidrug resistance-associated protein 1 (MRP1) is a member o...    Read more.

Read more MRP1 related blogs.