Mouse Wnt-3a DuoSet ELISA, 5 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse Wnt-3a DuoSet ELISA, 5 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Wnt-3a DuoSet ELISA, 5 Plate

• MGC119418
• MGC119419
• MGC119420
• protein Wnt-3a
• wingless-type MMTV integration site family, member 3A
• Wnt3a
• Wnt-3a

Background

Wnt-3a is a secreted protein that is necessary for proper embryonic development of the hippocampus, anterior-posterior patterning, somite development, and tailbud formation. It also promotes self-renewal of hematopoietic stem cells, neural stem cells, and embryonic stem cells. The post-translational glycosylation and acylation of Wnts are essential for their efficient secretion and biological activity, respectively. Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta-catenin levels. As intracellular beta-catenin levels rise, beta-catenin binds to TCF/LEF transcription factors leading to expression of Wnt target genes.

Publications for Wnt-3a (DY1324B-05)(3)

Publications using DY1324B-05

• N Azazmeh, B Assouline, E Winter, S Ruppo, Y Nevo, A Maly, K Meir, AK Witkiewicz, J Cohen, SV Rizou, E Pikarsky, C Luxenburg, VG Gorgoulis, I Ben-Porath Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation Nat Commun, 2020-06-01;11(1):2711. 2020-06-01 [PMID: 32483135] (Mouse)
• CB Chen, WC Chang, MY Wu, TY Kao, YW Wang, CW Wang, CJ Chen, WH Chung, SC Su Attenuation of Wnt/beta-catenin signaling in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis Int. J. Biol. Sci., 2020-01-01;16(2):353-364. 2020-01-01 [PMID: 31929762] (Human)
• SR Mallery, D Wang, B Santiago, P Pei, C Bissonnett, JA Jayawarden, SP Schwendema, R Spinney, J Lang Fenretinide, Tocilizumab & Reparixin Provide Multifaceted Disruption of Oral Squamous Cell Carcinoma Stem Cell Properties: Implications for Tertiary chemoprevention Mol. Cancer Ther., 2019-09-12;0(0):. 2019-09-12 [PMID: 31515297] (Human)