Mouse/Rat TNF RII/TNFRSF1B Quantikine ELISA Kit

• Reactivity: Mu, Rt
• Applications: ELISA
• Conjugate: HRP

Mouse/Rat TNF RII/TNFRSF1B Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse/Rat TNF RII Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse or rat TNF RII in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse TNF RII and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant protein accurately. Results obtained using natur...al mouse or rat TNF RII showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse or rat TNF RII.
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• Specificity: Natural and recombinant mouse and rat TNF RII
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Tnfrsf1b

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse/Rat TNF RII/TNFRSF1B Quantikine ELISA Kit

• CD120b antigen
• CD120b
• Etanercept
• p75 TNF receptor
• p75TBPII
• p75TNFR
• soluble TNFR1B variant 1
• TNF RII
• TNFBRp80 TNF-alpha receptor
• TNF-R2
• TNFR2TNFR1B
• TNF-R75
• TNFR80
• TNFRII
• TNF-RII
• TNF-R-II
• TNFR-II
• TNFRSF1B
• tumor necrosis factor beta receptor
• tumor necrosis factor binding protein 2
• Tumor necrosis factor receptor 2
• tumor necrosis factor receptor superfamily member 1B
• tumor necrosis factor receptor superfamily, member 1B
• Tumor necrosis factor receptor type II

Background

TNF RII (Tumor Necrosis Factor Receptor II), also known as TNFRSF1B, p75/p80, and CD120b, is a widely expressed receptor for membrane-associated TNF-alpha and Lymphotoxin-alpha. Its activation initiates pro-inflammatory and pro-survival responses via NFkB-dependent signaling pathways, although it may also induce apoptosis.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for TNF RII/TNFRSF1B (MRT20)(16)

Publications using MRT20

• I Cho, BN Koo, SY Kim, S Park, EJ Kim, EH Kam, J Kim Neuroprotective Effect of Dexmedetomidine against Postoperative Cognitive Decline via NLRP3 Inflammasome Signaling Pathway International Journal of Molecular Sciences, 2022-08-08;23(15):. 2022-08-08 [PMID: 35955939] (Mouse)
• Z Li, M Murakoshi, S Ichikawa, T Koshida, E Adachi, C Suzuki, S Ueda, T Gohda, Y Suzuki The sodium-glucose cotransporter 2 inhibitor tofogliflozin prevents diabetic kidney disease progression in type 2 diabetic mice FEBS Open Bio, 2020-11-10;0(0):. 2020-11-10 [PMID: 33098615] (Mouse)
• Awad A, You H, Gao T, Cooper T, Nedospasov S, Vacher J, Wilkinson P, Farrell F, Brian Reeves W Macrophage-derived tumor necrosis factor-alpha mediates diabetic renal injury. Kidney Int, 2015-06-10;88(4):722-33. 2015-06-10 [PMID: 26061548] (Mouse)
• Mallipattu S, Liu R, Zhong Y, Chen E, D'Agati V, Kaufman L, Ma'ayan A, Klotman P, Chuang P, He J Expression of HIV transgene aggravates kidney injury in diabetic mice. Kidney Int, 2013-01-16;83(4):626-34. 2013-01-16 [PMID: 23325078] (Mouse)
• Wahl EC, Aronson J, Liu L, Fowlkes JL, Thrailkill KM, Bunn RC, Skinner RA, Miller MJ, Cockrell GE, Clark LM, Ou Y, Isales CM, Badger TM, Ronis MJ, Sims J, Lumpkin CK Restoration of regenerative osteoblastogenesis in aged mice: modulation of TNF. J. Bone Miner. Res., 2010-01-01;25(1):114-23. 2010-01-01 [PMID: 19580462] (Mouse)
• Olleros ML, Martin ML, Vesin D, Fotio AL, Santiago-Raber ML, Rubbia-Brandt L, Spahr L, Hadengue A, Garcia I Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokines. Cytokine, 2008-08-22;44(1):118-25. 2008-08-22 [PMID: 18722787] (Mouse)
• Lahat N, Rahat MA, Kinarty A, Weiss-Cerem L, Pinchevski S, Bitterman H Hypoxia enhances lysosomal TNF-alpha degradation in mouse peritoneal macrophages. Am. J. Physiol., Cell Physiol., 2008-04-23;295(1):C2-12. 2008-04-23 [PMID: 18434619] (Mouse)
• Wilson MR, Goddard ME, O'Dea KP, O'Dea KP, Choudhury S, Takata M Differential roles of p55 and p75 tumor necrosis factor receptors on stretch-induced pulmonary edema in mice. Am. J. Physiol. Lung Cell Mol. Physiol., 2007-04-13;293(1):L60-8. 2007-04-13 [PMID: 17435079] (Mouse)
• Frances R, Chiva M, Sanchez E, Gonzalez-Navajas JM, Llovet T, Zapater P, Soriano G, Munoz C, Balanzo J, Perez-Mateo M, Song XY, Guarner C, Such J Bacterial translocation is downregulated by anti-TNF-alpha monoclonal antibody administration in rats with cirrhosis and ascites. J. Hepatol., 2006-12-27;46(5):797-803. 2006-12-27 [PMID: 17321632] (Rat)
• Tellier E, Rebsomen L The shedding activity of ADAM17 is sequestered in lipid rafts. Exp. Cell Res., 2006-09-05;312(20):3969-80. 2006-09-05 [PMID: 17010968] (Mouse, Rat)
• Canault M, Tellier E, Bonardo B, Mas E, Aumailley M, Juhan-Vague I, Nalbone G, Peiretti F FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity. J. Cell. Physiol., 2006-08-01;208(2):363-72. 2006-08-01 [PMID: 16619241] (Mouse)
• Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW, Biswal S Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J. Clin. Invest., 2006-04-01;116(4):984-95. 2006-04-01 [PMID: 16585964] (Mouse)
• D'hulst AI, Bracke KR, Maes T, De Bleecker JL, Pauwels RA, Joos GF, Brusselle GG Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema. Eur. Respir. J., 2006-03-15;28(1):102-12. 2006-03-15 [PMID: 16540505] (Mouse)
• Petelin M, Naruishi K, Shiomi N, Mineshiba J, Arai H, Nishimura F, Takashiba S, Murayama Y Systemic up-regulation of sTNFR2 and IL-6 in Porphyromonas gingivalis pneumonia in mice. Exp. Mol. Pathol., 2004-02-01;76(1):76-81. 2004-02-01 [PMID: 14738872] (Mouse)
• Hanisch UK, Prinz M, Angstwurm K, Hausler KG, Kann O, Kettenmann H, Weber JR The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. Eur. J. Immunol., 2001-07-01;31(7):2104-15. 2001-07-01 [PMID: 11449364] (Mouse)
• Jin L, Raymond DP, Crabtree TD, Pelletier SJ, Houlgrave CW, Pruett TL, Sawyer RG Enhanced murine macrophage TNF receptor shedding by cytosine-guanine sequences in oligodeoxynucleotides. J. Immunol., 2000-11-01;165(9):5153-60. 2000-11-01 [PMID: 11046047] (Mouse)

Bioinformatics

• Gene Symbol: Tnfrsf1b