Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit

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Reactivity Mu, RtSpecies Glossary
Applications ELISA

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Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit Summary

The Quantikine Mouse/Rat IGF-I Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse and rat IGF-I in cell culture supernates, tissue homogenates, serum, and plasma. It contains E. coli-expressed recombinant mouse IGF-I and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtain...ed using natural mouse and rat IGF-I showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring mouse/rat IGF-I.
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Natural and recombinant mouse and rat IGF-I
Assay Type
Solid Phase Sandwich ELISA
See PDF Datasheet for details
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details


Application Notes
No significant interference observed with available related molecules.
Read Publications using
MG100 in the following applications:

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit

  • IBP1
  • IGF1
  • IGF-1
  • IGF1A
  • IGFI
  • IGF-I
  • IGF-IA
  • IGF-IB
  • insulin-like growth factor 1 (somatomedin C)
  • insulin-like growth factor 1
  • insulin-like growth factor I
  • insulin-like growth factor IA
  • insulin-like growth factor IB
  • Mechano growth factor
  • MGF
  • Somatomedin A
  • Somatomedin C
  • somatomedin-C


Insulin-like Growth Factor 1 (IGF-1), also known as somatomedin C, is a member of the insulin superfamily. It was originally discovered as a mediator of growth hormone actions on somatic cell growth, but has also been shown to be an important regulator of cell metabolism, differentiation and survival. IGF-1 is synthesized as a preproprotein that is proteolytically cleaved to generate the mature protein linked by three disulfide bonds. Mature IGF-1 is highly conserved among large mammals, with 100% sequence identity between the human, bovine, porcine, equine, and canine proteins. 

Mature mouse IGF-1 is a non-glycosylated, 70 amino acid (aa) secreted polypeptide that is derived from either a 153 aa or a 159 aa preproprotein. It shares 99% and 94% aa sequence identity with rat and human IGF-1, respectively. IGF-1 is synthesized in the liver and other tissues. It is found in blood and other body fluids as a complex with specific high affinity IGF binding proteins (IGFBP-1 to -6). The IGFBPs are expressed in specific patterns during development. They are modulators of IGF actions, which control IGF bioavailability to specific cell-surface receptors. Their functions are further regulated by IGFBP proteases, which proteolytically cleave the IGFBPs to lower the affinity with which they bind IGFs and increase IGF bioavailability. Some IGFBPs also have IGF-Independent effects on cell functions. IGF-Independent circulates primarily as a ternary complex with IGFBP-3 or IGFBP-5 and the acid-labile subunit (ALS). Some IGF-1 is also present in binary complexes with other IGFBPs. Whereas the ternary complexes are generally restricted to the vasculature, the binary complexes freely enter the tissues. 

IGF-1 actions are mediated by two ubiquitously expressed receptor tyrosine kinases: IGF-I R and Insulin R/CD220. IGF-I R and Insulin R are disulfide-linked heterotetrameric complexes that consist of two alpha and two beta subunits. For both of these receptors, the prepro proteins are cleaved to produce extracellular alpha subunits which contain a cysteine-rich region and ligand-binding fibronectin type III (FN-III) domains, and beta subunits which contain an extracellular FN-III domain, transmembrane, and cytoplasmic tyrosine kinase domains. A hybrid complex containing one IGF-I R and one Insulin R also serves as a functional high affinity receptor for IGF-1. IGF-I R-Insulin R hybrids respond primarily to IGF-1, potentially downregulating the cellular response to Insulin. IGF signaling is also modulated by IGF binding proteins and the scavenger receptor, IGF-I I R.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to

Publications for IGF-I/IGF-1 (MG100)(157)

We have publications tested in 4 confirmed species: Mouse, Rat, Bovine, Transgenic Mouse.

We have publications tested in 1 application: ELISA (Standard).

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Showing Publications 1 - 10 of 157. Show All 157 Publications.
Publications using MG100 Applications Species
K Yamanaka, Y Haraguchi, H Takahashi, I Kawashima, T Shimizu Development of serum-free and grain-derived-nutrient-free medium using microalga-derived nutrients and mammalian cell-secreted growth factors for sustainable cultured meat production Scientific Reports, 2023;13(1):498. 2023 [PMID: 36627406] (Bovine) Bovine
J Wang, Q Zhu, D Cao, Q Peng, X Zhang, C Li, C Zhang, BO Zhou, R Yue Bone marrow-derived IGF-1 orchestrates maintenance and regeneration of the adult skeleton Proceedings of the National Academy of Sciences of the United States of America, 2023;120(1):e2203779120. 2023 [PMID: 36577075] (Mouse) Mouse
S Ma, E Hasegawa, Y Nakai, H Jia, H Kato Transcriptome and Methylome Profiling in Rat Skeletal Muscle: Impact of Post-Weaning Protein Restriction International Journal of Molecular Sciences, 2022;23(24):. 2022 [PMID: 36555412] (Rat) Rat
A Hiroto, WK Kim, A Pineda, Y He, DH Lee, V Le, AW Olson, J Aldahl, CH Nenninger, AJ Buckley, GQ Xiao, J Geradts, Z Sun Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis Nature Communications, 2022;13(1):6552. 2022 [PMID: 36323713] (Mouse) Mouse
Z Liu, H Shi, J Xu, Q Yang, Q Ma, X Mao, Z Xu, Y Zhou, Q Da, Y Cai, DJ Fulton, Z Dong, A Sodhi, RB Caldwell, Y Huo Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy JCI Insight, 2022;7(23):. 2022 [PMID: 36264636] (Mouse) Mouse
MP LaPierre, K Lawler, S Godbersen, IS Farooqi, M Stoffel MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis Nature Communications, 2022;13(1):5733. 2022 [PMID: 36175420] (Mouse) Mouse
MM Nowacka-Ch, D Li?kiewicz, A Li?kiewicz, M Przyby?a, ? Marczak, A Wojakowska, K Grabowska, M Grabowski, JJ Barski, A Ma?ecki Global Proteome Profiling of the Temporal Cortex of Female Rats Exposed to Chronic Stress and the Western Diet Nutrients, 2022;14(9):. 2022 [PMID: 35565902] (Rat) Rat
H Nishi, K Uchida, M Saito, D Yamanaka, H Nagata, H Tomoshige, I Miyata, K Ito, Y Toyoshima, SI Takahashi, F Hakuno, A Takenaka Essential Amino Acid Intake Is Required for Sustaining Serum Insulin-like Growth Factor-I Levels but Is Not Necessarily Needed for Body Growth Cells, 2022;11(9):. 2022 [PMID: 35563827] (Mouse) Mouse
E Mendes de, JC Silva, TP Ascar, S Sandri, AF Marchi, S Migliorini, HTI Nakaya, RA Fock, A Campa Acute Inflammation Is a Predisposing Factor for Weight Gain and Insulin Resistance Pharmaceutics, 2022;14(3):. 2022 [PMID: 35335996] (Mouse) Mouse
SH Lee, CR Kim, YC Cho, SN Kim, BH Kim, C Lee, HB Ji, JH Han, CG Park, H Hong, YB Choy Magnetically actuating implantable pump for the on-demand and needle-free administration of human growth hormone International journal of pharmaceutics, 2022;618(0):121664. 2022 [PMID: 35292393] (Rat) Rat
Show All 157 Publications.

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Gene Symbol Igf1