Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit

• Reactivity: Mu, Rt
• Applications: ELISA
• Conjugate: HRP

Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse/Rat IGF-I Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse and rat IGF-I in cell culture supernates, tissue homogenates, serum, and plasma. It contains E. coli-expressed recombinant mouse IGF-I and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtain...ed using natural mouse and rat IGF-I showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring mouse/rat IGF-I.
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• Specificity: Natural and recombinant mouse and rat IGF-I
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Igf1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit

• IBP1
• IGF1
• IGF-1
• IGF1A
• IGFI
• IGF-I
• IGF-IA
• IGF-IB
• insulin-like growth factor 1 (somatomedin C)
• insulin-like growth factor 1
• insulin-like growth factor I
• insulin-like growth factor IA
• insulin-like growth factor IB
• Mechano growth factor
• MGF
• Somatomedin A
• Somatomedin C
• somatomedin-C

Background

Insulin-like Growth Factor 1 (IGF-1), also known as somatomedin C, is a member of the insulin superfamily. It was originally discovered as a mediator of growth hormone actions on somatic cell growth, but has also been shown to be an important regulator of cell metabolism, differentiation and survival. IGF-1 is synthesized as a preproprotein that is proteolytically cleaved to generate the mature protein linked by three disulfide bonds. Mature IGF-1 is highly conserved among large mammals, with 100% sequence identity between the human, bovine, porcine, equine, and canine proteins. 

Mature mouse IGF-1 is a non-glycosylated, 70 amino acid (aa) secreted polypeptide that is derived from either a 153 aa or a 159 aa preproprotein. It shares 99% and 94% aa sequence identity with rat and human IGF-1, respectively. IGF-1 is synthesized in the liver and other tissues. It is found in blood and other body fluids as a complex with specific high affinity IGF binding proteins (IGFBP-1 to -6). The IGFBPs are expressed in specific patterns during development. They are modulators of IGF actions, which control IGF bioavailability to specific cell-surface receptors. Their functions are further regulated by IGFBP proteases, which proteolytically cleave the IGFBPs to lower the affinity with which they bind IGFs and increase IGF bioavailability. Some IGFBPs also have IGF-Independent effects on cell functions. IGF-Independent circulates primarily as a ternary complex with IGFBP-3 or IGFBP-5 and the acid-labile subunit (ALS). Some IGF-1 is also present in binary complexes with other IGFBPs. Whereas the ternary complexes are generally restricted to the vasculature, the binary complexes freely enter the tissues. 

IGF-1 actions are mediated by two ubiquitously expressed receptor tyrosine kinases: IGF-I R and Insulin R/CD220. IGF-I R and Insulin R are disulfide-linked heterotetrameric complexes that consist of two alpha and two beta subunits. For both of these receptors, the prepro proteins are cleaved to produce extracellular alpha subunits which contain a cysteine-rich region and ligand-binding fibronectin type III (FN-III) domains, and beta subunits which contain an extracellular FN-III domain, transmembrane, and cytoplasmic tyrosine kinase domains. A hybrid complex containing one IGF-I R and one Insulin R also serves as a functional high affinity receptor for IGF-1. IGF-I R-Insulin R hybrids respond primarily to IGF-1, potentially downregulating the cellular response to Insulin. IGF signaling is also modulated by IGF binding proteins and the scavenger receptor, IGF-I I R.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IGF-I/IGF-1 (MG100)(157)

Publications using MG100

• K Yamanaka, Y Haraguchi, H Takahashi, I Kawashima, T Shimizu Development of serum-free and grain-derived-nutrient-free medium using microalga-derived nutrients and mammalian cell-secreted growth factors for sustainable cultured meat production Scientific Reports, 2023;13(1):498. 2023 [PMID: 36627406] (Bovine)
• J Wang, Q Zhu, D Cao, Q Peng, X Zhang, C Li, C Zhang, BO Zhou, R Yue Bone marrow-derived IGF-1 orchestrates maintenance and regeneration of the adult skeleton Proceedings of the National Academy of Sciences of the United States of America, 2023;120(1):e2203779120. 2023 [PMID: 36577075] (Mouse)
• S Ma, E Hasegawa, Y Nakai, H Jia, H Kato Transcriptome and Methylome Profiling in Rat Skeletal Muscle: Impact of Post-Weaning Protein Restriction International Journal of Molecular Sciences, 2022;23(24):. 2022 [PMID: 36555412] (Rat)
• A Hiroto, WK Kim, A Pineda, Y He, DH Lee, V Le, AW Olson, J Aldahl, CH Nenninger, AJ Buckley, GQ Xiao, J Geradts, Z Sun Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis Nature Communications, 2022;13(1):6552. 2022 [PMID: 36323713] (Mouse)
• Z Liu, H Shi, J Xu, Q Yang, Q Ma, X Mao, Z Xu, Y Zhou, Q Da, Y Cai, DJ Fulton, Z Dong, A Sodhi, RB Caldwell, Y Huo Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy JCI Insight, 2022;7(23):. 2022 [PMID: 36264636] (Mouse)
• MP LaPierre, K Lawler, S Godbersen, IS Farooqi, M Stoffel MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis Nature Communications, 2022;13(1):5733. 2022 [PMID: 36175420] (Mouse)
• MM Nowacka-Ch, D Li?kiewicz, A Li?kiewicz, M Przyby?a, ? Marczak, A Wojakowska, K Grabowska, M Grabowski, JJ Barski, A Ma?ecki Global Proteome Profiling of the Temporal Cortex of Female Rats Exposed to Chronic Stress and the Western Diet Nutrients, 2022;14(9):. 2022 [PMID: 35565902] (Rat)
• H Nishi, K Uchida, M Saito, D Yamanaka, H Nagata, H Tomoshige, I Miyata, K Ito, Y Toyoshima, SI Takahashi, F Hakuno, A Takenaka Essential Amino Acid Intake Is Required for Sustaining Serum Insulin-like Growth Factor-I Levels but Is Not Necessarily Needed for Body Growth Cells, 2022;11(9):. 2022 [PMID: 35563827] (Mouse)
• E Mendes de, JC Silva, TP Ascar, S Sandri, AF Marchi, S Migliorini, HTI Nakaya, RA Fock, A Campa Acute Inflammation Is a Predisposing Factor for Weight Gain and Insulin Resistance Pharmaceutics, 2022;14(3):. 2022 [PMID: 35335996] (Mouse)
• SH Lee, CR Kim, YC Cho, SN Kim, BH Kim, C Lee, HB Ji, JH Han, CG Park, H Hong, YB Choy Magnetically actuating implantable pump for the on-demand and needle-free administration of human growth hormone International journal of pharmaceutics, 2022;618(0):121664. 2022 [PMID: 35292393] (Rat)
• YY Sung, SH Kim, DS Kim Combined Phyllostachys pubescens and Scutellaria baicalensis Prevent High-Fat Diet-Induced Obesity via Upregulating Thermogenesis and Energy Expenditure by UCP1 in Male C57BL/6J Mice Nutrients, 2022;14(3):. 2022 [PMID: 35276805] (Mouse)
• J Dereke, E Ekblad, B Weström, C Erlanson-A, M Landin-Ols, I Sjöholm, M Hillman Structural and immunoendocrine remodeling in gut, pancreas and thymus in weaning rats fed powdered milk diets rich in Maillard reactants Scientific Reports, 2022;12(1):4039. 2022 [PMID: 35260716] (Rat)
• F D'Addio, A Maestroni, E Assi, M Ben Nasr, G Amabile, V Usuelli, C Loretelli, F Bertuzzi, B Antonioli, F Cardarelli, B El Essawy, A Solini, IC Gerling, C Bianchi, G Becchi, S Mazzucchel, D Corradi, GP Fadini, D Foschi, JF Markmann, E Orsi, J Škrha, MG Camboni, R Abdi, AM James Shap, F Folli, J Ludvigsson, S Del Prato, G Zuccotti, P Fiorina The IGFBP3/TMEM219 pathway regulates beta cell homeostasis Nature Communications, 2022;13(1):684. 2022 [PMID: 35115561] (Mouse)
• KH Kim, KA Lee Metabolic Rewiring by Human Placenta-Derived Mesenchymal Stem Cell Therapy Promotes Rejuvenation in Aged Female Rats International Journal of Molecular Sciences, 2022;23(1):. 2022 [PMID: 35008991] (Rat)
• M Darnaud, F De Vadder, P Bogeat, L Boucinha, AL Bulteau, A Bunescu, C Couturier, A Delgado, H Dugua, C Elie, A Mathieu, T Novotná, DA Ouattara, S Planel, A Saliou, D Šr?tková, J Yansouni, B Stecher, M Schwarzer, F Leulier, A Tamellini A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes Nature Communications, 2021;12(1):6686. 2021 [PMID: 34795236] (Mouse)
• LCD Pomatto-Wa, M Bodogai, O Bosompra, J Kato, S Wong, M Carpenter, E Duregon, D Chowdhury, P Krishna, S Ng, E Ragonnaud, R Salgado, P Gonzalez E, A Diaz-Ruiz, M Bernier, NL Price, A Biragyn, VD Longo, R de Cabo Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition Nature Communications, 2021;12(1):6201. 2021 [PMID: 34707136] (Mouse)
• AS Alshinnawy, WM El-Sayed, AA Sayed, AM Salem, AM Taha Telomerase activator-65 and pomegranate peel improved the health status of the liver in aged rats; multi-targets involved Iranian journal of basic medical sciences, 2021;24(6):842-850. 2021 [PMID: 34630962] (Rat)
• K Kurup, SN Mann, J Jackson, S Matyi, M Ranjo-Bish, WM Freeman, MB Stout, A Richardson, A Unnikrishn Litter expansion alters metabolic homeostasis in a sex specific manner PLoS ONE, 2021;16(9):e0237199. 2021 [PMID: 34587168] (Mouse)
• BK Schilling, JS Baker, C Komatsu, KG Marra Intramuscular injection of skeletal muscle derived extracellular matrix mitigates denervation atrophy after sciatic nerve transection Journal of tissue engineering, 2021;12(0):2041731421103. 2021 [PMID: 34567507] (Rat)
• P Maity, K Singh, L Krug, A Koroma, A Hainzl, W Bloch, S Kochanek, M Wlaschek, M Schorpp-Ki, P Angel, A Ignatius, H Geiger, K Scharffett Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging Cell Reports, 2021;36(9):109634. 2021 [PMID: 34469740] (Transgenic Mouse)
• HJ Kok, CN Crowder, L Koo Min Ch, HY Choi, N Lin, ER Barton Muscle insulin-like growth factor-I modulates murine craniofacial bone growth European cells & materials, 2021;41(0):72-89. 2021 [PMID: 34279041] (Mouse)
• S Ock, W Ham, CW Kang, H Kang, WS Lee, J Kim IGF-1 protects against angiotensin II-induced cardiac fibrosis by targeting alphaSMA Cell Death & Disease, 2021;12(7):688. 2021 [PMID: 34244467] (Mouse)
• O Nychyk, W Barton, AM Rudolf, S Boscaini, A Walsh, TFS Bastiaanss, L Giblin, P Cormican, L Chen, Y Piotrowicz, D Derous, Á Fanning, X Yin, J Grant, S Melgar, L Brennan, SE Mitchell, JF Cryan, J Wang, PD Cotter, JR Speakman, KN Nilaweera Protein quality and quantity influence the effect of dietary fat on weight gain and tissue partitioning via host-microbiota changes Cell Reports, 2021;35(6):109093. 2021 [PMID: 33979605] (Mouse)
• JD Plummer, SD Postnikoff, JK Tyler, JE Johnson Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice Elife, 2021;10(0):. 2021 [PMID: 33783357] (Mouse)
• M Icyuz, F Zhang, MP Fitch, MR Joyner, AK Challa, LY Sun Physiological and metabolic characteristics of novel double-mutant female mice with targeted disruption of both growth hormone-releasing hormone and growth hormone receptor Aging Cell, 2021;0(0):e13339. 2021 [PMID: 33755309] (Mouse)
• DW Dodington, JL Yumol, J Yang, E Pollock-Ta, T Sivasubram, SM Sacco, SA Schroer, YE Li, H Le, WE Ward, M Woo JAK2-IGF1 axis in osteoclasts regulates postnatal growth in mice JCI Insight, 2021;6(5):. 2021 [PMID: 33682794] (Mouse)
• MM Elshemy, M Asem, KS Allemailem, K Uto, M Ebara, A Nabil Antioxidative Capacity of Liver- and Adipose-Derived Mesenchymal Stem Cell-Conditioned Media and Their Applicability in Treatment of Type 2 Diabetic Rats Oxidative Medicine and Cellular Longevity, 2021;2021(0):8833467. 2021 [PMID: 33623636] (Rat)
• SL Hsu, WY Chou, CC Hsu, JY Ko, SW Jhan, CJ Wang, MS Lee, TC Hsu, JH Cheng Shockwave Therapy Modulates the Expression of BMP2 for Prevention of Bone and Cartilage Loss in the Lower Limbs of Postmenopausal Osteoporosis Rat Model Biomedicines, 2020;8(12):. 2020 [PMID: 33333838] (Rat)
• SJ Blaschke, S Demir, A König, JA Abraham, SU Vay, M Rabenstein, DN Olschewski, C Hoffmann, M Hoffmann, N Hersch, R Merkel, B Hoffmann, M Schroeter, GR Fink, MA Rueger Substrate Elasticity Exerts Functional Effects on Primary Microglia Front Cell Neurosci, 2020;14(0):590500. 2020 [PMID: 33250714] (Rat)
• SM Grundmann, A Schutkowsk, C Berger, AC Baur, B König, GI Stangl High-phosphorus diets reduce aortic lesions and cardiomyocyte size and modify lipid metabolism in Ldl receptor knockout mice Sci Rep, 2020;10(1):20748. 2020 [PMID: 33247205] (Mouse)
• M Portero-Tr, D Rojic-Beck, C Vega-Carba, G Guillazo-B, A Vale-Martí, M Martí-Nico Caloric restriction modulates the monoaminergic system and metabolic hormones in aged rats Sci Rep, 2020;10(1):19299. 2020 [PMID: 33168891] (Rat)
• W El Bakly, M Medhat, M Shafei, R Tash, M Elrefai, Y Shoukry, NN Omar Optimized platelet rich plasma releasate (O-rPRP) repairs galactosemia-induced ovarian follicular loss in rats by activating mTOR signaling and inhibiting apoptosis Heliyon, 2020;6(9):e05006. 2020 [PMID: 33005806] (Rat)
• B Cakir, W Hellström, Y Tomita, Z Fu, R Liegl, A Winberg, I Hansen-Pup, D Ley, A Hellström, C Löfqvist, LE Smith IGF1, serum glucose, and retinopathy of prematurity in extremely preterm infants JCI Insight, 2020;5(19):. 2020 [PMID: 33004691] (Mouse)
• N Kawamura, G Katsuura, N Yamada-Got, E Novianti, A Inui, A Asakawa Reduced brain fractalkine-CX3CR1 signaling is involved in the impaired cognition of streptozotocin-treated mice IBRO Rep, 2020;9(0):233-240. 2020 [PMID: 32995659] (Mouse)
• D Abboud, AF Daly, N Dupuis, MA Bahri, A Inoue, A Chevigné, F Ectors, A Plenevaux, B Pirotte, A Beckers, J Hanson GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 Nat Commun, 2020;11(1):4752. 2020 [PMID: 32958754] (Mouse)
• S Yamamoto, C Sakemoto, K Iwasa, K Maruyama, K Shimizu, K Yoshikawa Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1 J. Pharmacol. Sci., 2020;144(3):119-122. 2020 [PMID: 32921392] (Mouse)
• KD Beharry, CL Cai, F Siddiqui, C D'Agrosa, A Zangaladze, G Mustafa, A Qadri, TJ Duggan, JV Aranda Combination Antioxidant/NSAID Therapies and Oral/Topical Ocular Delivery Modes for Prevention of Oxygen-Induced Retinopathy in a Rat Model Nutrients, 2020;12(7):. 2020 [PMID: 32635350] (Rat)
• JA Seo, MC Kang, WM Yang, WM Hwang, SS Kim, SH Hong, JI Heo, A Vijyakumar, L Pereira de, A Uner, H Huang, SH Lee, IS Lima, KS Park, MS Kim, Y Dagon, TE Willnow, V Aroda, TP Ciaraldi, RR Henry, YB Kim Apolipoprotein�J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity Nat Commun, 2020;11(1):2024. 2020 [PMID: 32332780] (Mouse)
• KK Poh, PSS Lee, AH Djohan, MJ Galupo, GG Songco, TC Yeo, HC Tan, AM Richards, L Ye Transplantation of Endothelial Progenitor Cells in Obese Diabetic Rats Following Myocardial Infarction: Role of Thymosin Beta-4 Cells, 2020;9(4):. 2020 [PMID: 32290541] (Rat)
• S Guzel, CL Cai, T Ahmad, M Quan, GB Valencia, JV Aranda, KD Beharry Bumetanide Suppression of Angiogenesis in a Rat Model of Oxygen-Induced Retinopathy Int J Mol Sci, 2020;21(3):. 2020 [PMID: 32024231] (Rat)
• T Nemoto, Y Kakinuma Fetal malnutrition-induced catch up failure is caused by elevated levels of miR-322 in rats Sci Rep, 2020;10(1):1339. 2020 [PMID: 31992823] (Rat)
• C Desclée de, G Carlin, A Oosting, C Delteil, D Azzout-Mar, C Chaumontet, F Blachier, P Barbillon, T Mary-Huard, D Tomé, R Oozeer, AM Davila Increased Susceptibility to Obesity and Glucose Intolerance in Adult Female Rats Programmed by High-Protein Diet during Gestation, But Not during Lactation Nutrients, 2020;12(2):. 2020 [PMID: 31991777] (Mouse)
• S Sanchez-Be, ND Åberg, P Crock, FR Walker, M Nilsson, J Isgaard, LK Ong Growth Hormone Promotes Motor Function after Experimental Stroke and Enhances Recovery-Promoting Mechanisms within the Peri-Infarct Area Int J Mol Sci, 2020;21(2):. 2020 [PMID: 31963456] (Mouse)
• R Nakao, T Abe, S Yamamoto, K Oishi Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in mice Sci Rep, 2019;9(1):19652. 2019 [PMID: 31873138] (Mouse)
• T Abe, R Kazama, H Okauchi, K Oishi Food deprivation during active phase induces skeletal muscle atrophy via IGF-1 reduction in mice Arch. Biochem. Biophys., 2019;0(0):108160. 2019 [PMID: 31639326] (Mouse)
• CC Hsiao, CC Lin, YS Hou, JY Ko, CJ Wang Low-Energy Extracorporeal Shock Wave Ameliorates Streptozotocin Induced Diabetes and Promotes Pancreatic Beta Cells Regeneration in a Rat Model Int J Mol Sci, 2019;20(19):. 2019 [PMID: 31590394] (Rat)
• YZ Zhou, Z Cheng, Y Wu, QY Wu, XB Liao, Y Zhao, JM Li, XM Zhou, XM Fu Mesenchymal stem cell-derived conditioned medium attenuate angiotensin II-induced aortic aneurysm growth by modulating macrophage polarization J. Cell. Mol. Med., 2019;0(0):. 2019 [PMID: 31583844] (Mouse)
• M Machida, S Shiga, T Machida, M Ohno, K Iizuka, M Hirafuji Potentiation of Glucagon-Like Peptide-2 Dynamics by Methotrexate Administration in Rat Small Intestine Biol. Pharm. Bull., 2019;42(10):1733-1740. 2019 [PMID: 31582661] (Rat)
• YF Mahran, AM Badr, A Aldosari, R Bin-Zaid, HN Alotaibi Carvacrol and Thymol Modulate the Cross-Talk between TNF-α and IGF-1 Signaling in Radiotherapy-Induced Ovarian Failure Oxid Med Cell Longev, 2019;2019(0):3173745. 2019 [PMID: 31531182] (Rat)
• RG Paul, AS Hennebry, MS Elston, JV Conaglen, CD McMahon Regulation of murine skeletal muscle growth by STAT5B is age- and sex-specific Skelet Muscle, 2019;9(1):19. 2019 [PMID: 31230596] (Mouse)
• D Kremer, J Gruchot, V Weyers, L Oldemeier, P Göttle, L Healy, J Ho Jang, Y Kang T Xu, C Volsko, R Dutta, BD Trapp, H Perron, HP Hartung, P Küry pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):. 2019 [PMID: 31213545] (Rat)
• P Shao, Y Wang, M Zhang, X Wen, J Zhang, Z Xu, M Hu, J Jiang, T Liu The interference of DEHP in precocious puberty of females mediated by the hypothalamic IGF-1/PI3K/Akt/mTOR signaling pathway Ecotoxicol. Environ. Saf., 2019;181(0):362-369. 2019 [PMID: 31212184] (Rat)
• JM Liefhebber, R Martier, T Van der Zo, S Keskin, A Huseinovic, J Lubelski, B Blits, H Petry, P Konstantin In-Depth Characterization of a Mifepristone-Regulated Expression System for AAV5-Mediated Gene Therapy in the Liver Mol Ther Methods Clin Dev, 2019;13(0):512-525. 2019 [PMID: 31194088] (Mouse)
• G Favaro, V Romanello, T Varanita, M Andrea Des, V Morbidoni, C Tezze, M Albiero, M Canato, G Gherardi, D De Stefani, C Mammucari, B Blaauw, S Boncompagn, F Protasi, C Reggiani, L Scorrano, L Salviati, M Sandri DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass Nat Commun, 2019;10(1):2576. 2019 [PMID: 31189900] (Mouse)
• H Zhou, X Lei, Y Yan, T Lydic, J Li, NL Weintraub, H Su, W Chen Targeting ATGL to rescue BSCL2 lipodystrophy and its associated cardiomyopathy JCI Insight, 2019;5(0):. 2019 [PMID: 31185001] (Mouse)
• SH Lee, H Piao, YC Cho, SN Kim, G Choi, CR Kim, HB Ji, CG Park, C Lee, CI Shin, WG Koh, YB Choy, JH Choy Implantable multireservoir device with stimulus-responsive membrane for on-demand and pulsatile delivery of growth hormone Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):. 2019 [PMID: 31123147] (Rat)
• G Sendžikait, CW Hanna, KR Stewart-Mo, E Ivanova, G Kelsey A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice Nat Commun, 2019;10(1):1884. 2019 [PMID: 31015495] (Mouse)
• IV Kravchenko, VA Furalyov, VO Popov Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy Biochem Biophys Rep, 2019;18(0):100627. 2019 [PMID: 30957033] (Mouse)
• TT Williamson, B Ding, X Zhu, RD Frisina Hormone replacement therapy attenuates hearing loss: Mechanisms involving estrogen and the IGF-1 pathway Aging Cell, 2019;0(0):e12939. 2019 [PMID: 30845368] (Mouse)
• J Lopez, A Quan, J Budihardjo, S Xiang, H Wang, Kiron Kosh, C Cashman, WPA Lee, A Hoke, S Tuffaha, G Brandacher Growth Hormone Improves Nerve Regeneration, Muscle Re-innervation, and Functional Outcomes After Chronic Denervation Injury Sci Rep, 2019;9(1):3117. 2019 [PMID: 30816300] (Rat)
• Y Zhuo, L Hua, B Feng, X Jiang, J Li, D Jiang, X Huang, Y Zhu, Z Li, L Yan, C Jin, L Che, Z Fang, Y Lin, S Xu, J Li, Wu Fibroblast growth factor 21 coordinates adiponectin to mediate the beneficial effects of low-protein diet on primordial follicle reserve EBioMedicine, 2019;41(0):623-635. 2019 [PMID: 30772303] (Mouse)
• SL Tang, ZW Zhao, SM Liu, G Wang, XH Yu, J Zou, SQ Wang, XY Dai, MG Fu, XL Zheng, DW Zhang, H Fu, CK Tang Pregnancy-Associated Plasma Protein-A Accelerates Atherosclerosis by Regulating Reverse Cholesterol Transport and Inflammation Circ. J., 2019;0(0):. 2019 [PMID: 30662023] (Mouse)
• BG Lania, J Morari, AR Almeida, MND Silva, G Vieira-Dam, KA Lins, CL César, LA Velloso, NB Maia, ML Cintra, PENF Velho Topical essential fatty acid oil on wounds: Local and systemic effects PLoS ONE, 2019;14(1):e0210059. 2019 [PMID: 30608959] (Mouse)
• S Jung, JH Kim, C Yim, M Lee, HJ Kang, D Choi Therapeutic effects of a mesenchymal stem cell?based insulin?like growth factor?1/enhanced green fluorescent protein dual gene sorting system in a myocardial infarction rat model Mol Med Rep, 2018;0(0):. 2018 [PMID: 30365087] (Rat)
• X Zhang, JK Yang, C Chen Enhanced Pulsatile Growth Hormone Secretion and Altered Metabolic Hormones by in Vivo Hexarelin Treatment in Streptozotocin-Induced Diabetic Rats Int J Mol Sci, 2018;19(10):. 2018 [PMID: 30297647] (Rat)
• C Bárcena, PM Quirós, S Durand, P Mayoral, F Rodríguez, XM Caravia, G Mariño, C Garabaya, MT Fernández-, G Kroemer, JMP Freije, C López-Otín Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism Cell Rep, 2018;24(9):2392-2403. 2018 [PMID: 30157432] (Mouse)
• K Mao, GF Quipildor, T Tabrizian, A Novaj, F Guan, RO Walters, F Delahaye, GB Hubbard, Y Ikeno, K Ejima, P Li, DB Allison, H Salimi-Moo, PJ Beltran, P Cohen, N Barzilai, DM Huffman Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice Nat Commun, 2018;9(1):2394. 2018 [PMID: 29921922] (Mouse)
• C Youssif, M Cubillos-R, M Comalada, E Llonch, C Perna, N Djouder, AR Nebreda Myeloid p38? signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis EMBO Mol Med, 2018;0(0):. 2018 [PMID: 29907597] (Mouse)
• AAA Taha, M Koshiyama, N Matsumura, K Abiko, K Yamaguchi, J Hamanishi, T Baba, B Kharma, IH Mohamed, MM Ameen, SA Ismail, I Konishi, M Mandai The effect of the type of dietary protein on the development of ovarian cancer Oncotarget, 2018;9(35):23987-23999. 2018 [PMID: 29844867] (Rat)
• LK Ong, WZ Chow, C TeBay, M Kluge, G Pietrogran, K Zalewska, P Crock, ND Åberg, A Bivard, SJ Johnson, FR Walker, M Nilsson, J Isgaard Growth Hormone Improves Cognitive Function After Experimental Stroke Stroke, 2018;0(0):. 2018 [PMID: 29636425] (Mouse)
• J Lu, L Lu, Y Yu, J Cluette-Br, CR Martin, EC Claud Effects of Intestinal Microbiota on Brain Development in Humanized Gnotobiotic Mice Sci Rep, 2018;8(1):5443. 2018 [PMID: 29615691] (Mouse)
• JD Koerner, DZ Markova, GD Schroeder, BP Calio, A Shah, CW Brooks, AR Vaccaro, DG Anderson, CK Kepler The local cytokine and growth factor response to rhBMP-2 after spinal fusion Spine J, 2018;0(0):. 2018 [PMID: 29550606] (ELISA (Standard), Rat)
• C Cai, T Ahmad, GB Valencia, JV Aranda, J Xu, KD Beharry Intermittent hypoxia suppression of growth hormone and insulin-like growth factor-I in the neonatal rat liver Growth Horm. IGF Res., 2018;0(0):. 2018 [PMID: 29544682] (Rat)
• L Wang, M Yang, M Jin, Y Wu, T Zheng, S Gu, X Hua Transplant of insulin-like growth factor-1 expressing bone marrow stem cells improves functional regeneration of injured rat uterus by NF-?B pathway J. Cell. Mol. Med., 2018;0(0):. 2018 [PMID: 29516621] (Rat)
• M Linder, M Hecking, E Glitzner, K Zwerina, M Holcmann, L Bakiri, MG Ruocco, J Tuckermann, G Schett, EF Wagner, M Sibilia EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation Cell Death Differ., 2018;0(0):. 2018 [PMID: 29445126] (Mouse)
• VST Rodrigues, EG Moura, DN Bernardino, JC Carvalho, PN Soares, TC Peixoto, N Peixoto-Si, E Oliveira, PC Lisboa Supplementation of suckling rats with cow's milk induces hyperphagia and higher visceral adiposity in females at adulthood, but not in males J. Nutr. Biochem., 2017;55(0):89-103. 2017 [PMID: 29413493] (Rat)
• Y Takahashi, R Watanabe, Y Sato, N Ozawa, M Kojima, K Watanabe-K, R Shirai, K Sato, T Hirano, T Watanabe Novel phytopeptide osmotin mimics preventive effects of adiponectin on vascular inflammation and atherosclerosis Metab. Clin. Exp., 2018;0(0):. 2018 [PMID: 29410350] (Mouse)
• D Aguado-Lle, S Canelles, LM Frago, JA Chowen, J Argente, E Arilla, V Barrios The Protective Effects of IGF-I against ?-Amyloid-related Downregulation of Hippocampal Somatostatinergic System Involve Activation of Akt and Protein Kinase A Neuroscience, 2018;374(0):104-118. 2018 [PMID: 29406271] (Rat)
• BG Lania, J Morari, AL Souza, MND Silva, AR de Almeida, G Veira-Dami, SM Alegre, CL César, LA Velloso, ML Cintra, NB Maia, PENF Velho Topical use and systemic action of green and roasted coffee oils and ground oils in a cutaneous incision model in rats (Rattus norvegicus albinus) PLoS ONE, 2017;12(12):e0188779. 2017 [PMID: 29236720] (Rat)
• M Chennaoui, PJ Arnal, R Dorey, F Sauvet, S Ciret, T Gallopin, D Leger, C Drogou, D Gomez-Meri Changes of Cerebral and/or Peripheral Adenosine A? Receptor and IGF-I Concentrations under Extended Sleep Duration in Rats Int J Mol Sci, 2017;18(11):. 2017 [PMID: 29149028] (Rat)
• ARR Lima, LU Pagan, RL Damatto, MDM Cezar, C Bonomo, MJ Gomes, PF Martinez, DM Guizoni, DHS Campos, FC Damatto, K Okoshi, MP Okoshi Effects of growth hormone on cardiac remodeling and soleus muscle in rats with aortic stenosis-induced heart failure Oncotarget, 2017;8(47):83009-83021. 2017 [PMID: 29137319] (Rat)
• KN Charles, MD Li, F Engin, AP Arruda, K Inouye, GS Hotamislig Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins Cell Rep, 2017;21(2):393-402. 2017 [PMID: 29020626] (Mouse)
• MC Fernandez, R Rayes, B Ham, N Wang, F Bourdeau, S Milette, M Lllemann, N Bird, A Majeed, J Xu, T Kisselova, P Brodt The type I insulin-like growth factor regulates the liver stromal response to metastatic colon carcinoma cells Oncotarget, 2017;8(32):52281-52293. 2017 [PMID: 28881729] (Mouse)
• R Cintron-Co, M Sanchez-Al, W Nguyen, S Mori, R Gonzalez-R, T Lien, T Bartfai, S Aïd, JC François, M Holzenberg, B Conti Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):. 2017 [PMID: 28827363] (Mouse)
• XW Tan, CL Ji, LL Zheng, J Zhang, HJ Yuan, S Gong, J Zhu, JH Tan Corticotrophin-releasing hormone and corticosterone impair development of preimplantation embryos by inducing oviductal cell apoptosis via activating the Fas system: an in vitro study Hum. Reprod., 2017;0(0):1-15. 2017 [PMID: 28591825] (Mouse)
• M Kugita, K Nishii, T Yamaguchi, A Suzuki, Y Yuzawa, S Horie, E Higashihar, S Nagao Beneficial effect of combined treatment with octreotide and pasireotide in PCK rats, an orthologous model of human autosomal recessive polycystic kidney disease PLoS ONE, 2017;12(5):e0177934. 2017 [PMID: 28542433] (Rat)
• M Kondo, Y Koyama, Y Nakamura, S Shimada A novel 5HT3 receptor-IGF1 mechanism distinct from SSRI-induced antidepressant effects Mol. Psychiatry, 2017;0(0):. 2017 [PMID: 28439104] (Mouse)
• NM Ashpole, S Logan, A Yabluchans, MC Mitschelen, H Yan, JA Farley, EL Hodges, Z Ungvari, A Csiszar, S Chen, C Georgescu, GB Hubbard, Y Ikeno, WE Sonntag IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan Geroscience, 2017;0(0):. 2017 [PMID: 28409331] (Mouse)
• Z Wang, X Xiao, R Ge, J Li, CW Johnson, C Rassoulian, AF Olumi Metformin inhibits the proliferation of benign prostatic epithelial cells PLoS ONE, 2017;12(3):e0173335. 2017 [PMID: 28253329] (Mouse)
• S Becker, H Wang, B Yu, R Brown, X Han, RH Lane, ME Hartnett Protective effect of maternal uteroplacental insufficiency on oxygen-induced retinopathy in offspring: removing bias of premature birth Sci Rep, 2017;7(0):42301. 2017 [PMID: 28195189] (Rat)
• L Luo, C Yan, Y Urata, AS Hasan, S Goto, CY Guo, S Zhang, TS Li Dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells of mice Sci Rep, 2017;7(0):40959. 2017 [PMID: 28098222] (Mouse)
• RJ Tamming, JR Siu, Y Jiang, MA Prado, F Beier, NG B?rub? Mosaic expression of Atrx in the mouse central nervous system causes memory deficits Dis Model Mech, 2017;10(2):119-126. 2017 [PMID: 28093507] (Mouse)
• Positive Prehabilitative Effect of Intense Treadmill Exercise for Ameliorating Cancer Cachexia Symptoms in a Mouse Model J Cancer, 2016;7(15):2378-2387. 2016 [PMID: 27994677] (Mouse)
• Lisa C Burnett Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome J. Clin. Invest, 2016;0(0):. 2016 [PMID: 27941249] (Mouse)
• Li Zhou Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery Biomaterials, 2016;117(0):24-31. 2016 [PMID: 27923197] (Mouse)
• The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats J Neuroinflammation, 2016;13(1):300. 2016 [PMID: 27905989] (Rat)
• First steps to define murine amniotic fluid stem cell microenvironment Sci Rep, 2016;6(0):37080. 2016 [PMID: 27845396] (Mouse)
• Fibroblast growth factor 21 has no direct role in regulating fertility in female mice Mol Metab, 2016;5(8):690-8. 2016 [PMID: 27656406] (Mouse)
• Space radiation exposure persistently increased leptin and IGF1 in serum and activated leptin-IGF1 signaling axis in mouse intestine Sci Rep, 2016;6(0):31853. 2016 [PMID: 27558773] (Mouse)
• Tsutomu Hashidume Single ingestion of soy ?-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects Sci Rep, 2016;6(0):28183. 2016 [PMID: 27312476] (Mouse)
• Thor Tejada IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction Proc Natl Acad Sci USA, 2016;0(0):. 2016 [PMID: 27274047] (Mouse)
• Radiation Exposure Decreases the Quantity and Quality of Cardiac Stem Cells in Mice PLoS ONE, 2016;11(5):e0152179. 2016 [PMID: 27195709] (Mouse)
• Cluster Differentiating 36 (CD36) Deficiency Attenuates Obesity-Associated Oxidative Stress in the Heart PLoS ONE, 2016;11(5):e0155611. 2016 [PMID: 27195707] (Mouse)
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• Conti V, Gandaglia A, Galli F, Tirone M, Bellini E, Campana L, Kilstrup-Nielsen C, Rovere-Querini P, Brunelli S, Landsberger N MeCP2 Affects Skeletal Muscle Growth and Morphology through Non Cell-Autonomous Mechanisms. PLoS ONE, 2015;10(6):e0130183. 2015 [PMID: 26098633] (Mouse)
• Charolidi N, Schilling T, Eder C Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice. PLoS ONE, 2015;10(5):e0128463. 2015 [PMID: 26011191] (Mouse)
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• Sapra , Geeta, Tham , Yow Keat, Cemerlang , Nelly, Matsumoto , Aya, Kiriazis , Helen, Bernardo , Bianca C, Henstridge , Darren C, Ooi , Jenny Y, Pretorius , Lynette, Boey , Esther J, Lim , Lydia, Sadoshima , Junichi, Meikle , Peter J, Mellet , Natalie, Woodcock , Elizabet, Marasco , Silvana, Ueyama , Tomomi, Du , Xiao-Jun, Febbraio , Mark A, McMullen , Julie R The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice. Nat Commun, 2014;5(0):5705. 2014 [PMID: 25489988] (Mouse)
• Nuytens , Kim, Tuand , Krizia, Fu , Quili, Stijnen , Pieter, Pruniau , Vincent, Meulemans , Sandra, Vankelecom , Hugo, Creemers , John W M The dwarf phenotype in GH240B mice, haploinsufficient for the autism candidate gene Neurobeachin, is caused by ectopic expression of recombinant human growth hormone. PLoS ONE, 2014;9(10):e109598. 2014 [PMID: 25333629] (Mouse)
• Hwang D, Shin H, Kwon M, Choi J, Ryu B, Kim B Survival of neural stem cell grafts in the lesioned spinal cord is enhanced by a combination of treadmill locomotor training via insulin-like growth factor-1 signaling. J Neurosci, 2014;34(38):12788-800. 2014 [PMID: 25232115] (Rat)
• Zgheib S, Mequinion M, Lucas S, Leterme D, Ghali O, Tolle V, Zizzari P, Bellefontaine N, Legroux-Gerot I, Hardouin P, Broux O, Viltart O, Chauveau C Long-term physiological alterations and recovery in a mouse model of separation associated with time-restricted feeding: a tool to study anorexia nervosa related consequences. PLoS ONE, 2014;9(8):e103775. 2014 [PMID: 25090643] (Mouse)
• Baltes J, Larsen J, Radhakrishnan K, Geumann C, Kratzke M, Petersen C, Schu P sigma1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue. J Cell Sci, 2014;127(0):3477-87. 2014 [PMID: 24928897] (Mouse)
• Kuno T, Hata K, Takamatsu M, Hara A, Hirose Y, Takahashi S, Imaida K, Tanaka T The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate suppresses chemically induced lung alveolar proliferative lesions in male obese hyperlipidemic mice. Int J Mol Sci, 2014;15(5):9160-72. 2014 [PMID: 24857924] (Mouse)
• Fernandez-Perez L, Santana-Farre R, de Mirecki-Garrido M, Garcia I, Guerra B, Mateo-Diaz C, Iglesias-Gato D, Diaz-Chico J, Flores-Morales A, Diaz M Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver. PLoS ONE, 2014;9(5):e96305. 2014 [PMID: 24816529] (Rat)
• Harvey A, Lashinger L, Hays D, Harrison L, Lewis K, Fischer S, Hursting S Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-kappaB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner. PLoS ONE, 2014;9(5):e94151. 2014 [PMID: 24804677] (Mouse)
• Gealekman O, Gurav K, Chouinard M, Straubhaar J, Thompson M, Malkani S, Hartigan C, Corvera S Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4. J Biol Chem, 2014;289(26):18327-38. 2014 [PMID: 24778188] (Mouse)
• Mellott T, Pender S, Burke R, Langley E, Blusztajn J IGF2 ameliorates amyloidosis, increases cholinergic marker expression and raises BMP9 and neurotrophin levels in the hippocampus of the APPswePS1dE9 Alzheimer's disease model mice. PLoS ONE, 2014;9(4):e94287. 2014 [PMID: 24732467] (Mouse)
• Ogasawara R, Sato K, Matsutani K, Nakazato K, Fujita S The order of concurrent endurance and resistance exercise modifies mTOR signaling and protein synthesis in rat skeletal muscle. Am J Physiol Endocrinol Metab, 2014;306(10):E1155-62. 2014 [PMID: 24691029] (Rat)
• Jiang X, McClellan S, Barrett R, Foldenauer M, Hazlett L HGF signaling impacts severity of Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci, 2014;55(4):2180-90. 2014 [PMID: 24618323] (Mouse)
• Oduwole O, Vydra N, Wood N, Samanta L, Owen L, Keevil B, Donaldson M, Naresh K, Huhtaniemi I Overlapping dose responses of spermatogenic and extragonadal testosterone actions jeopardize the principle of hormonal male contraception. FASEB J, 2014;28(6):2566-76. 2014 [PMID: 24599970] (Mouse)
• Piccioni A, Gaetani E, Palladino M, Gatto I, Smith R, Neri V, Marcantoni M, Giarretta I, Silver M, Straino S, Capogrossi M, Landolfi R, Pola R Sonic hedgehog gene therapy increases the ability of the dystrophic skeletal muscle to regenerate after injury. Gene Ther, 2014;21(4):413-21. 2014 [PMID: 24572787] (Mouse)
• Brisson , Becky K, Spinazzola , Janelle, Park , SooHyun, Barton , Elisabet Viral expression of insulin-like growth factor I E-peptides increases skeletal muscle mass but at the expense of strength. Am J Physiol Endocrinol Metab, 2014;306(8):E965-74. 2014 [PMID: 24569593] (Mouse)
• Izumi , Hirohisa, Kosaka , Nobuyosh, Shimizu , Takashi, Sekine , Kazunori, Ochiya , Takahiro, Takase , Mitsunor Time-dependent expression profiles of microRNAs and mRNAs in rat milk whey. PLoS ONE, 2014;9(2):e88843. 2014 [PMID: 24533154] (Rat)
• Parlee , Sebastia, Simon , Becky R, Scheller , Erica L, Alejandro , Emilyn U, Learman , Brian S, Krishnan , Venkates, Bernal-Mizrachi , Ernesto, MacDougald , Ormond A Administration of saccharin to neonatal mice influences body composition of adult males and reduces body weight of females. Endocrinology, 2014;155(4):1313-26. 2014 [PMID: 24456165] (Mouse)
• Hirose J, Masuda H, Tokuyama N, Omata Y, Matsumoto T, Yasui T, Kadono Y, Hennighausen L, Tanaka S Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5-Dusp axis in the osteoclast. J Exp Med, 2014;211(1):153-63. 2014 [PMID: 24367002] (Mouse)
• Keipert S, Ost M, Johann K, Imber F, Jastroch M, van Schothorst E, Keijer J, Klaus S Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine. Am J Physiol Endocrinol Metab, 2014;306(5):E469-82. 2014 [PMID: 24347058] (Mouse)
• Burke R, Norman T, Haydar T, Slack B, Leeman S, Blusztajn J, Mellott T BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A, 2013;110(48):19567-72. 2013 [PMID: 24218590] (Mouse)
• Steyn , F J, Lee , K, Fogarty , M J, Veldhuis , J D, McCombe , P A, Bellingham , M C, Ngo , S T, Chen , C Growth hormone secretion is correlated with neuromuscular innervation rather than motor neuron number in early-symptomatic male amyotrophic lateral sclerosis mice. Endocrinology, 2013;154(12):4695-706. 2013 [PMID: 24108071] (Mouse)
• Ock , Sangmi, Ahn , Jihyun, Lee , Seok Hon, Kang , Hyun, Offermanns , Stefan, Ahn , Hwa Youn, Jo , Young Su, Shong , Minho, Cho , Bo Youn, Jo , Daewoong, Abel , E Dale, Lee , Tae Jin, Park , Woo Jin, Lee , In-Kyu, Kim , Jaetaek IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter. FASEB J, 2013;27(12):4899-908. 2013 [PMID: 23982142] (Mouse)
• Yamamoto , Masaaki, Iguchi , Genzo, Fukuoka , Hidenori, Suda , Kentaro, Bando , Hironori, Takahashi , Michiko, Nishizawa , Hitoshi, Seino , Susumu, Takahashi , Yutaka SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver. Proc Natl Acad Sci U S A, 2013;110(37):14948-53. 2013 [PMID: 23980167] (Mouse)
• Lloyd J, Masko E, Wu C, Keenan M, Pilla D, Aronson W, Chi J, Freedland S Fish oil slows prostate cancer xenograft growth relative to other dietary fats and is associated with decreased mitochondrial and insulin pathway gene expression. Prostate Cancer Prostatic Dis, 2013;16(4):285-91. 2013 [PMID: 23877027] (Mouse)
• Al-Qusairi L, Prokic I, Amoasii L, Kretz C, Messaddeq N, Mandel J, Laporte J Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways. FASEB J, 2013;27(8):3384-94. 2013 [PMID: 23695157] (Mouse)
• Crispel , Yonatan, Katz , Oren, Ben-Yosef , Dafna, Hochberg , Ze'ev Effects of breastfeeding on body composition and maturational tempo in the rat. BMC Med, 2013;11(0):114. 2013 [PMID: 23627911] (Rat)
• Osuka S, Sampetrean O, Shimizu T, Saga I, Onishi N, Sugihara E, Okubo J, Fujita S, Takano S, Matsumura A, Saya H IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells. Stem Cells, 2013;31(4):627-40. 2013 [PMID: 23335250] (Mouse)
• Sen S, Jumaa H, Webster N Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function. Nat Commun, 2013;4(0):1336. 2013 [PMID: 23299886] (Mouse)
• Takehara , Yuji, Yabuuchi , Akiko, Ezoe , Kenji, Kuroda , Tomoko, Yamadera , Rie, Sano , Chiaki, Murata , Nana, Aida , Takuya, Nakama , Ken, Aono , Fumihito, Aoyama , Naoki, Kato , Keiich, Kato , Osamu The restorative effects of adipose-derived mesenchymal stem cells on damaged ovarian function. Lab Invest, 2013;93(2):181-93. 2013 [PMID: 23212100] (Rat)
• Al-Dwairi , Ahmed, Pabona , John Mar, Simmen , Rosalia, Simmen , Frank A Cytosolic Malic Enzyme 1 (ME1) Mediates High Fat Diet-Induced Adiposity, Endocrine Profile, and Gastrointestinal Tract Proliferation-Associated Biomarkers in Male Mice. PLoS ONE, 2012;7(10):e46716. 2012 [PMID: 23056418] (Mouse)
• Ma B, Zhang Q, Wu D, Wang YL, Hu YY, Cheng YP, Yang ZD, Zheng YY, Ying HJ Strontium fructose 1,6-diphosphate prevents bone loss in a rat model of postmenopausal osteoporosis via the OPG/RANKL/RANK pathway. Acta Pharmacol. Sin., 2012;33(4):479-89. 2012 [PMID: 22426695] (Rat)
• Hua Y, Sahashi K, Rigo F Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model. Nature, 2011;478(7367):123-6. 2011 [PMID: 21979052] (Mouse)
• Maurer GD, Brucker DP, Bahr O, Harter PN, Hattingen E, Walenta S, Mueller-Klieser W, Steinbach JP, Rieger J Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. BMC Cancer, 2011;11(0):315. 2011 [PMID: 21791085] (Mouse)
• De Lorenzo M, Baljinnyam E, Vatner D, Abarzua P, Vatner S, Rabson A Caloric restriction reduces growth of mammary tumors and metastases. Carcinogenesis, 0;32(9):1381-7. 0 [PMID: 21665891] (Mouse)
• Nguyen KH, Yao XH, Moulik S, Mishra S, Nyomba BL Human IGF Binding Protein-3 Overexpression Impairs Glucose Regulation in Mice via an Inhibition of Insulin Secretion. Endocrinology, 2011;152(6):2184-96. 2011 [PMID: 21447640] (Mouse)
• Sato H, Isogai Y, Masuda S Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function. J. Biol. Chem., 2011;286(13):11632-48. 2011 [PMID: 21266581] (Mouse)
• Yasuda T, Shibasaki T, Minami K Rim2alpha determines docking and priming States in insulin granule exocytosis. Cell Metab., 2010;12(2):117-29. 2010 [PMID: 20674857] (Mouse)
• Chambon C, Duteil D, Vignaud A, Ferry A, Messaddeq N, Malivindi R, Kato S, Chambon P, Metzger D Myocytic androgen receptor controls the strength but not the mass of limb muscles. Proc. Natl. Acad. Sci. U.S.A., 2010;107(32):14327-32. 2010 [PMID: 20660752] (Mouse)
• Doverhag C, Hedtjarn M, Poirier F, Mallard C, Hagberg H, Karlsson A, Savman K Galectin-3 contributes to neonatal hypoxic-ischemic brain injury. Neurobiol. Dis., 2010;38(1):36-46. 2010 [PMID: 20053377] (Mouse)
• Koronyo-Hamaoui M, Ko MK, Koronyo Y, Azoulay D, Seksenyan A, Kunis G, Pham M, Bakhsheshian J, Rogeri P, Black KL, Farkas DL, Schwartz M Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9. J. Neurochem., 2009;111(6):1409-24. 2009 [PMID: 19780903] (Mouse)
• Yang H, Dixit VD, Patel K, Vandanmagsar B, Collins G, Sun Y, Smith RG, Taub DD Reduction in hypophyseal growth hormone and prolactin expression due to deficiency in ghrelin receptor signaling is associated with Pit-1 suppression: Relevance to the immune system. Brain Behav. Immun., 2008;0(0):. 2008 [PMID: 18602461] (Mouse)
• Ashare A, Nymon AB, Doerschug KC, Morrison JM, Monick MM, Hunninghake GW Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance. Am. J. Respir. Crit. Care Med., 2008;178(2):149-57. 2008 [PMID: 18436791] (Mouse)
• Cheung WW, Rosengren S, Boyle DL, Mak RH Modulation of melanocortin signaling ameliorates uremic cachexia. Kidney Int., 2008;74(2):180-6. 2008 [PMID: 18432186] (Mouse)
• Paintlia AS, Paintlia MK, Singh AK, Singh I Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. Mol. Pharmacol., 2008;73(5):1381-93. 2008 [PMID: 18239032] (Rat)
• Kubota Y, Unoki H, Bujo H, Rikihisa N, Udagawa A, Yoshimoto S, Ichinose M, Saito Y Low-dose GH supplementation reduces the TLR2 and TNF-alpha expressions in visceral fat. Biochem. Biophys. Res. Commun., 2008;368(1):81-7. 2008 [PMID: 18201559] (Mouse)
• Lanz TA, Salatto CT, Semproni AR, Marconi M, Brown TM, Richter KE, Schmidt K, Nelson FR, Schachter JB Peripheral elevation of IGF-1 fails to alter Abeta clearance in multiple in vivo models. Biochem. Pharmacol., 2007;75(5):1093-103. 2007 [PMID: 18076866] (Rat)
• Wang J, Wang C, Tsui HW, Las Heras F, Cheng EY, Iscove NN, Chiu B, Inman RD, Pritzker KP, Tsui FW Microcytosis in ank/ank mice and the role of ANKH in promoting erythroid differentiation. Exp. Cell Res., 2007;313(20):4120-9. 2007 [PMID: 17950726] (Mouse)
• Dixit VD, Yang H, Sun Y, Weeraratna AT, Youm YH, Smith RG, Taub DD Ghrelin promotes thymopoiesis during aging. J. Clin. Invest., 2007;117(10):2778-90. 2007 [PMID: 17823656] (Mouse)
• Yamaleyeva LM, Pendergrass KD, Pirro NT, Gallagher PE, Groban L, Chappell MC Ovariectomy is protective against renal injury in the high-salt-fed older mRen2.Lewis rat. Am. J. Physiol. Heart Circ. Physiol., 2007;293(4):H2064-71. 2007 [PMID: 17630347] (Rat)
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Bioinformatics

• Gene Symbol: Igf1