Mouse IL-6R alpha DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IL-6R alpha DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il6ra

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-6R alpha DuoSet ELISA, 15 Plate

• CD126
• gp80
• IL-6 R alpha
• IL6Q
• IL6R alpha
• IL-6R alpha
• IL6R
• IL-6R-1
• IL6RA
• IL-6Ra
• IL6RQ
• interleukin 6 receptor

Background

IL-6 R alpha is a transmembrane subunit of the receptor for Interleukin-6. It associates with gp130 which is a shared component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha. IL-6 plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis.

Publications for IL-6R alpha (DY1830)(12)

Publications using DY1830

• CM Flynn, Y Garbers, S Düsterhöft, R Wichert, J Lokau, CHK Lehmann, D Dudziak, B Schröder, C Becker-Pau, S Rose-John, S Aparicio-S, C Garbers Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro Scientific Reports, 2020-12-10;10(1):21612. 2020-12-10 [PMID: 33303781] (Mouse)
• N Uyama, H Tsutsui, S Wu, K Yasuda, E Hatano, XY Qin, S Kojima, J Fujimoto Anti-interleukin-6 receptor antibody treatment ameliorates postoperative adhesion formation Sci Rep, 2019-11-26;9(1):17558. 2019-11-26 [PMID: 31772282] (Mouse)
• NE McGregor, M Murat, J Elango, IJ Poulton, EC Walker, B Crimeen-Ir, PWM Ho, JH Gooi, TJ Martin, NA Sims IL-6 exhibits both cis and trans signaling in osteocytes and osteoblasts, but only�trans�signaling promotes bone formation and osteoclastogenesis J. Biol. Chem., 2019-03-28;0(0):. 2019-03-28 [PMID: 30923130] (Mouse)
• B Li, X Wang, IY Choi, YC Wang, S Liu, AT Pham, H Moon, DJ Smith, DS Rao, MP Boldin, L Yang miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity J. Clin. Invest., 2017-09-05;0(0):. 2017-09-05 [PMID: 28872459] (Mouse)
• J Tode, E Richert, S Koinzer, A Klettner, U Pickhinke, C Garbers, S Rose-John, B Nölle, J Roider Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice Cytokine, 2017-03-06;96(0):8-15. 2017-03-06 [PMID: 28267649] (Mouse)
• Cho S, Pirih F, Koh A, Michalski M, Eber M, Ritchie K, Sinder B, Oh S, Al-Dujaili S, Lee J, Kozloff K, Danciu T, Wronski T, McCauley L The soluble interleukin-6 receptor is a mediator of hematopoietic and skeletal actions of parathyroid hormone. J Biol Chem, 2013-01-07;288(10):6814-25. 2013-01-07 [PMID: 23297399] (Mouse)
• Wunderlich CM, Delic D, Behnke K, Meryk A, Strohle P, Chaurasia B, Al-Quraishy S, Wunderlich F, Bruning JC, Wunderlich FT Cutting edge: Inhibition of IL-6 trans-signaling protects from malaria-induced lethality in mice. J. Immunol., 2012-03-30;188(9):4141-4. 2012-03-30 [PMID: 22467660] (Mouse)
• Arndt PG, Strahan B, Wang Y, Long C, Horiuchi K, Walcheck B Leukocyte ADAM17 Regulates Acute Pulmonary Inflammation. PLoS ONE, 2011-05-16;6(5):e19938. 2011-05-16 [PMID: 21603616] (Mouse)
• Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J. Immunol., 2010-01-18;184(4):2130-9. 2010-01-18 [PMID: 20083667] (Mouse)
• Matsumoto S, Hara T, Mitsuyama K, Yamamoto M, Tsuruta O, Sata M, Scheller J, Rose-John S, Kado S, Takada T Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model. J. Immunol., 2009-12-30;184(3):1543-51. 2009-12-30 [PMID: 20042582] (Mouse)
• Wan S, Zhou Z, Duan B, Morel L Direct B cell stimulation by dendritic cells in a mouse model of lupus. Arthritis Rheum., 2008-06-01;8(0):1741-50. 2008-06-01 [PMID: 18512810] (Mouse)
• Coles B, Fielding CA, Rose-John S, Scheller J, Jones SA, O'Donnell VB Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo. Am. J. Pathol., 2007-07-01;171(1):315-25. 2007-07-01 [PMID: 17591976] (Mouse)

Bioinformatics

• Gene Symbol: Il6ra