Mouse IL-17F DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IL-17F DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il17f

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-17F DuoSet ELISA, 15 Plate

• Cytokine ML-1
• IL17F
• IL-17F
• IL-17Finterleukin-17F
• interleukin 17F

Background

The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Publications for IL-17F (DY2057)(13)

Publications using DY2057

• JQ Yang, KW Kalim, Y Li, Y Zheng, F Guo Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation J. Leukoc. Biol., 2019-07-01;0(0):. 2019-07-01 [PMID: 31260596] (Mouse)
• C Tang, S Kakuta, K Shimizu, M Kadoki, T Kamiya, T Shimazu, S Kubo, S Saijo, H Ishigame, S Nakae, Y Iwakura Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota Nat. Immunol., 2018-06-18;0(0):. 2018-06-18 [PMID: 29915298] (Mouse)
• JS Bowers, MH Nelson, K Majchrzak, SR Bailey, B Rohrer, AD Kaiser, C Atkinson, L Gattinoni, CM Paulos Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion JCI Insight, 2017-03-09;2(5):e90772. 2017-03-09 [PMID: 28289713] (Mouse)
• Bernard N, Finlay C, Tannahill G, Cassidy J, O'Neill L, Mills K A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis. Mucosal Immunol, 2014-12-17;8(5):982-92. 2014-12-17 [PMID: 25515629] (Mouse)
• Dulek D, Newcomb D, Goleniewska K, Cephus J, Zhou W, Reiss S, Toki S, Ye F, Zaynagetdinov R, Sherrill T, Blackwell T, Moore M, Boyd K, Kolls J, Peebles R Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner. Infect Immun, 2014-06-23;82(9):3723-39. 2014-06-23 [PMID: 24958709] (Mouse)
• Nedrud J, Bagheri N, Schon K, Xin W, Bergroth H, Eliasson D, Lycke N Subcomponent vaccine based on CTA1-DD adjuvant with incorporated UreB class II peptides stimulates protective Helicobacter pylori immunity. PLoS ONE, 2013-12-31;8(12):e83321. 2013-12-31 [PMID: 24391754] (Mouse)
• Dubin PJ, Martz A, Eisenstatt JR, Fox MD, Logar A, Kolls JK Interleukin-23-mediated inflammation in Pseudomonas aeruginosa pulmonary infection. Infect. Immun., 2011-10-24;80(1):398-409. 2011-10-24 [PMID: 22025517] (Mouse)
• Blumberg H, Dinh H, Dean C, Trueblood ES, Bailey K, Shows D, Bhagavathula N, Aslam MN, Varani J, Towne JE, Sims JE IL-1RL2 and its ligands contribute to the cytokine network in psoriasis. J. Immunol., 2010-09-10;185(7):4354-62. 2010-09-10 [PMID: 20833839] (Mouse)
• Meeks KD, Sieve AN, Kolls JK, Ghilardi N, Berg RE IL-23 is required for protection against systemic infection with Listeria monocytogenes. J. Immunol., 2009-12-15;183(12):8026-34. 2009-12-15 [PMID: 19923464] (Mouse)
• Nichols JR, Aldrich AL, Mariani MM, Vidlak D, Esen N, Kielian T TLR2 deficiency leads to increased Th17 infiltrates in experimental brain abscesses. J. Immunol., 2009-06-01;182(11):7119-30. 2009-06-01 [PMID: 19454709] (Mouse)
• Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C, Iwakura Y Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity, 2009-01-16;30(1):108-19. 2009-01-16 [PMID: 19144317] (Mouse)
• Rickel EA, Siegel LA, Yoon BR, Rottman JB, Kugler DG, Swart DA, Anders PM, Tocker JE, Comeau MR, Budelsky AL Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J. Immunol., 2008-09-15;181(6):4299-310. 2008-09-15 [PMID: 18768888] (Mouse)
• Wei L, Laurence A, Elias KM, O'Shea JJ IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J. Biol. Chem., 2007-09-20;282(48):34605-10. 2007-09-20 [PMID: 17884812] (Mouse)

FAQs for IL-17F (DY2057). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Il17f