Mouse IL-12 p70 Quantikine ELISA Kit, 2 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse IL-12 p70 Quantikine ELISA Kit, 2 Plate Summary

• Background: The Quantikine Mouse IL-12 p70 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-12 p70 in cell culture supernates and mouse serum. It contains recombinant mouse IL-12 expressed in Sf 21 insect cells using a baculovirus expression vector and antibodies raised against recombinant mouse IL-12. This immunoassay has been shown to accurately quantitate the recombin...ant factor. Results obtained using natural mouse IL-12 showed linear curves that were parallel to the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-12 p70.
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• Specificity: Natural and recombinant mouse IL-12 p70
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il12a

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-12 p70 Quantikine ELISA Kit, 2 Plate

• CLMF p35
• Cytotoxic lymphocyte maturation factor 35 kDa subunit
• IL12 p70
• IL-12 p70
• IL-12 subunit p35
• IL-12, subunit p35
• interleukin 12, p35
• interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocytematuration factor 1, p35)
• interleukin-12 alpha chain
• interleukin-12 subunit alpha
• natural killer cell stimulatory factor 1, 35 kD subunit
• NF cell stimulatory factor chain 1
• NK cell stimulatory factor chain 1
• NKSF1
• p35

Background

Interleukin 12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. The IL-12 p40 subunit is shared by IL-23, another heterodimeric cytokine that has biological activities similar to, as well as distinct from, IL-12. IL-12 is produced by macrophages and B cells and has been shown to have multiple effects on T cells and natural killer (NK) cells. While mouse IL-12 is active on both human and mouse cells, human IL-12 is not active on mouse cells.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IL-12 p70/IL-12A (M1270)(124)

Publications using M1270

• Zhu, T;Shen, Q;Shen, L;Wang, Y;Zhu, B;Ma, L;Feng, S;Wang, C;Yan, S;Li, J;Chen, Z;Zhou, J;Huang, H;Li, B;Shen, Z;Wang, Q;Wang, J;Gwinner, W;Scheffner, I;Rong, S;Yang, B;Wang, J;Haller, H;Han, X;Guo, G;Yin, Z;Jin, J;Lan, HY;Chen, J;Jiang, H; Senescence-induced p21high macrophages contributed to CD8+ T cells-related immune hyporesponsiveness in kidney transplantation via Zfp36/IL-27 axis Cell discovery 2025-04-15 [PMID: 40234384] (Mouse)
• Albarracin, L;Dentice Maidana, S;Fukuyama, K;Elean, M;Argañaraz Aybar, JN;Suda, Y;Nishiyama, K;Kitazawa, H;Villena, J; Orally Administered Lactobacilli Strains Modulate Alveolar Macrophages and Improve Protection Against Respiratory Superinfection Biomolecules 2024-12-14 [PMID: 39766307] (Mouse)
• Gil-de-Gómez, L;Mattei, JJ;Lee, JH;Grupp, SA;Reid, GSD;Seif, AE; CD4+ T Cells Mediate Dendritic Cell Licensing to Promote Multi-Antigen Anti-Leukemic Immune Response Cancer medicine 2025-01-01 [PMID: 39727041] (Mouse)
• Blanco, T;Nakagawa, H;Musayeva, A;Krauthammer, M;Singh, RB;Narimatsu, A;Ge, H;Shoushtari, SI;Dana, R; Acquired Immunostimulatory Phenotype of Migratory CD103+ Dendritic Cells Promotes Alloimmunity Following Corneal Transplantation JCI insight 2024-09-05 [PMID: 39235864] (Mouse)
• Bova, V;Basilotta, R;Casili, G;Lanza, M;Filippone, A;Campolo, M;Capra, AP;Vitale, G;Chisari, G;Colarossi, C;Giuffrida, D;Paterniti, I;Esposito, E; The Protective Role of Troxerutin (Trox) in Counteracting Anaplastic Thyroid Carcinoma (ATC) Progression Biomedicines 2024-08-05 [PMID: 39200219] (Human)
• Roy, S;Roy, S;Halder, S;Jana, K;Ukil, A; Leishmania exploits host cAMP/EPAC/calcineurin signaling to induce an IL-33-mediated anti-inflammatory environment for the establishment of infection The Journal of biological chemistry 2024-05-13 [PMID: 38750790] (Mouse)
• Wang, Z;Chen, Y;Wu, H;Wang, M;Mao, L;Guo, X;Zhu, J;Ye, Z;Luo, X;Yang, X;Liu, X;Yang, J;Sheng, Z;Lee, J;Guo, Z;Liu, Y; Intravenous administration of IL-12 encoding self-replicating RNA-lipid nanoparticle complex leads to safe and effective antitumor responses Scientific reports 2024-03-28 [PMID: 38548896] (Mouse)
• Vannini, A;Parenti, F;Forghieri, C;Vannini, G;Barboni, C;Zaghini, A;Gianni, T;Campadelli-Fiume, G; Decrease in Heparan Sulphate Binding in Tropism-Retargeted Oncolytic Herpes Simplex Virus (ReHV) Delays Blood Clearance and Improves Systemic Anticancer Efficacy Cancers 2024-03-13 [PMID: 38539478] (Mouse)
• Zhang, Y;Song, Y;Wang, X;Shi, M;Lin, Y;Tao, D;Han, S; An NFAT1-C3a-C3aR Positive Feedback Loop in Tumor-Associated Macrophages Promotes a Glioma Stem Cell Malignant Phenotype Cancer immunology research 2024-01-30 [PMID: 38289255] (Mouse)
• Wang, J;Ling, D;Shi, L;Li, H;Peng, M;Wen, H;Liu, T;Liang, R;Lin, Y;Wei, L;Zhang, G;Chen, S; METTL3-mediated m6A methylation regulates ovarian cancer progression by recruiting myeloid-derived suppressor cells Cell & bioscience 2023-11-06 [PMID: 37932814] (Mouse, Transgenic Mouse)
• You, Y;Kim, SH;Kim, CH;Kim, IH;Shin, Y;Kim, TR;Sohn, M;Park, J; Immune-Stimulating Potential of Lacticaseibacillus rhamnosus LM1019 in RAW 264.7 Cells and Immunosuppressed Mice Induced by Cyclophosphamide Microorganisms 2023-09-13 [PMID: 37764156] (Mouse)
• Soon-Oh Hong, Joonsung Kim, Sungmin Lee, Jaeil Shin, Hwanjun Choi, Eunjin Lee et al. Transgenic viral expression of PH-20, IL-12, and sPD1-Fc enhances immune cell infiltration and anti-tumor efficacy of an oncolytic virus Mol Ther Oncolytics 2023-09-21 [PMID: 37727704] (Human)
• Jin, J;Fan, YJ;Nguyen, TV;Yu, ZN;Song, CH;Lee, SY;Shin, HS;Chai, OH; Fallopia japonica Root Extract Ameliorates Ovalbumin-Induced Airway Inflammation in a CARAS Mouse Model by Modulating the IL-33/TSLP/NF-?B Signaling Pathway International journal of molecular sciences 2023-08-07 [PMID: 37569890] (Mouse)
• Nikolas T. Martin, Mathieu J. F. Crupi, Zaid Taha, Joanna Poutou, Jack T. Whelan, Sydney Vallati et al. Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy Pharmaceuticals (Basel) 2023-05-07 [PMID: 37242495] (Mouse)
• KJ Smith, D Minns, BJ McHugh, RK Holloway, R O'Connor, A Williams, L Melrose, R McPherson, VE Miron, DJ Davidson, E Gwyer Find The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation PloS Biology, 2022-08-26;20(8):e3001554. 2022-08-26 [PMID: 36026478] (Mouse)
• S Pradhan, Snehlata, D Manna, S Karmakar, MK Singh, A Bhattachar, B Mukherjee, J Paul Activation of TLR-pathway to induce host Th1 immune response against visceral leishmaniasis: Involvement of galactosylated-flavonoids Heliyon, 2022-07-03;8(7):e09868. 2022-07-03 [PMID: 35847617] (Mouse)
• CY Shen, CF Lee, WT Chou, JJ Hwang, YS Tyan, HY Chuang Liposomal beta-Sitosterol Suppresses Metastasis of CT26/luc Colon Carcinoma via Inhibition of MMP-9 and Evoke of Immune System Pharmaceutics, 2022-06-07;14(6):. 2022-06-07 [PMID: 35745788] (Mouse)
• C Shi, S Wang, J Han, L Xi, M Li, Z Li, H Zhang Functional insights into Brucella transcriptional regulator ArsR Microbial pathogenesis, 2022-05-24;168(0):105557. 2022-05-24 [PMID: 35623565] (Mouse)
• E Sugisawa, T Kondo, Y Kumagai, H Kato, Y Takayama, K Isohashi, E Shimosegaw, N Takemura, Y Hayashi, T Sasaki, MM Martino, M Tominaga, K Maruyama Nociceptor-derived Reg3gamma prevents endotoxic death by targeting kynurenine pathway in microglia Cell Reports, 2022-03-08;38(10):110462. 2022-03-08 [PMID: 35263589] (Mouse)
• Jamilah Abusarah, Fatemeh Khodayarian, Nehme El-Hachem, Natasha Salame, Martin Olivier, Mohammad Balood, Katiane Roversi, Sebastien Talbot, Jean-Pierre Bikorimana, Jingkui Chen, Mario Jolicoeur, Louis-Eric Trudeau, Samaneh Kamyabiazar, Borhane Annabi, Francis Robert, Jerry Pelletier, Abed-El-Hakim El-Kadiry, Riam Shammaa, Moutih Rafei Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice Cell Rep Med 2021-12-21 [PMID: 35028603] (Mouse)
• S Kos, M Bosnjak, T Jesenko, B Markelc, U Kamensek, K Znidar, U Matkovic, A Rencelj, G Sersa, R Hudej, A Tuljak, M Peterka, M Cemazar Non-Clinical In Vitro Evaluation of Antibiotic Resistance Gene-Free Plasmids Encoding Human or Murine IL-12 Intended for First-in-Human Clinical Study Pharmaceutics, 2021-10-19;13(10):. 2021-10-19 [PMID: 34684032] (Mouse)
• QR Li, SR Tan, L Yang, W He, L Chen, FX Shen, Z Wang, HF Wang Mechanism of chlorogenic acid in alveolar macrophage polarization in Klebsiella pneumoniae-induced pneumonia Journal of leukocyte biology, 2021-09-29;0(0):. 2021-09-29 [PMID: 34585429] (Mouse)
• JT Zou, HM Jing, Y Yuan, LH Lei, ZF Chen, Q Gou, QS Xiong, XL Zhang, Z Zhao, XK Zhang, H Zeng, QM Zou, JY Zhang Pore-forming alpha-hemolysin efficiently improves the immunogenicity and protective efficacy of protein antigens PloS Pathogens, 2021-07-21;17(7):e1009752. 2021-07-21 [PMID: 34288976] (Mouse)
• HH Ahn, C Carrington, Y Hu, HW Liu, C Ng, H Nam, A Park, C Stace, W West, HQ Mao, MG Pomper, CG Ullman, I Minn Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers Scientific Reports, 2021-05-06;11(1):9733. 2021-05-06 [PMID: 33958660] (Mouse)
• Y Yuan, Y Ren, M Dijk, GI Geertsema-, J Atema-Smit, HJ Busscher, HC van der Me Phagocytosis and macrophage polarization on bacterially contaminated dental implant materials and effects on tissue integration European cells & materials, 2021-03-30;41(0):421-430. 2021-03-30 [PMID: 33782938] (Mouse)
• MR Charan Raj, A Kar, S Srinivasan, D Chellappan, J Debnath, S Kar Mahapa Oral administration of eugenol oleate cures experimental visceral leishmaniasis through cytokines abundance Cytokine, 2020-10-28;0(0):155301. 2020-10-28 [PMID: 33127258] (Mouse)
• J Xiao, G Zhang, S Gao, J Shen, H Feng, Z He, C Xu Combined administration of SHP2 inhibitor SHP099 and the &alpha7nAChR agonist PNU282987 protect mice against DSS?induced colitis Mol Med Rep, 2020-07-10;22(3):2235-2244. 2020-07-10 [PMID: 32705242] (Mouse)
• K Maruyama, H Kidoya, N Takemura, E Sugisawa, O Takeuchi, T Kondo, MMA Eid, H Tanaka, MM Martino, N Takakura, Y Takayama, S Akira, A Vandenbon, Y Kumagai Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages Cell Rep, 2020-07-14;32(2):107906. 2020-07-14 [PMID: 32668247] (Mouse)
• T Kawabe, J Yi, A Kawajiri, K Hilligan, D Fang, N Ishii, H Yamane, J Zhu, D Jankovic, KS Kim, G Trinchieri, A Sher Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state Nat Commun, 2020-07-06;11(1):3366. 2020-07-06 [PMID: 32632165] (Mouse)
• R Leylek, M Alcántara-, Z Lanzar, A Lüdtke, OA Perez, B Reizis, J Idoyaga Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population Cell Rep, 2019-12-10;29(11):3736-3750.e8. 2019-12-10 [PMID: 31825848] (Mouse)
• VA Balaji Rag, M Anwar, MZ Akhter, A Chavez, Y Mao, V Natarajan, S Lakshmikan, M Chrzanowsk, AZ Dudek, L Claesson-W, JK Kitajewski, KK Wary, AB Malik, D Mehta Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling Cell Rep, 2019-12-10;29(11):3472-3487.e4. 2019-12-10 [PMID: 31825830] (Mouse)
• T Iida, Daisuke Hi, N Minami, M Matsuura, K Wagatsuma, K Kawakami, K Nagaishi, M Nojima, H Ikeuchi, S Hirota, R Shirakawa, H Horiuchi, H Nakase Downregulation of RalGTPase-activating protein promotes colitis-associated cancer via NLRP3 inflammasome activation Cell Mol Gastroenterol Hepatol, 2019-10-15;0(0):. 2019-10-15 [PMID: 31622786] (Mouse)
• S Esaki, F Goshima, H Ozaki, G Takano, Y Hatano, D Kawakita, K Ijichi, T Watanabe, Y Sato, T Murata, H Iwata, Y Shibamoto, S Murakami, Y Nishiyama, H Kimura Oncolytic activity of HF10 in head and neck squamous cell carcinomas Cancer Gene Ther., 2019-09-03;0(0):. 2019-09-03 [PMID: 31477804] (Mouse)
• Z Li, Y Lin, S Zhang, L Zhou, G Yan, Y Wang, M Zhang, M Wang, H Lin, Q Tong, Y Duan, G Du Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis J Transl Med, 2019-03-18;17(1):90. 2019-03-18 [PMID: 30885207] (Mouse)
• J Zhang, H Li, Q Wu, Y Chen, Y Deng, Z Yang, L Zhang, B Liu Tumoral NOX4 recruits M2 tumor-associated macrophages via ROS/PI3K signaling-dependent various cytokine production to promote NSCLC growth Redox Biol, 2019-02-06;22(0):101116. 2019-02-06 [PMID: 30769285] (Mouse)
• S Simonetti, ABB Seijas, A Natalini, S Vitale, D Runci, A Soriani, A Di Virgili, E Aricò, L Gabriele, A Santoni, F Di Rosa Dendritic cells modulate c-kit expression on the edge between activation and death Eur. J. Immunol., 2019-02-25;0(0):. 2019-02-25 [PMID: 30758056] (Mouse)
• G Garaulet, G Pérez-Chac, H Alarcón, A Alfranca, F Mulero, J Martínez-T, JM Zapata, A Rodríguez Intratumoral expression using a NFkB-based promoter enhances IL12 antitumor efficacy Cancer Gene Ther., 2019-01-09;0(0):. 2019-01-09 [PMID: 30622324] (Mouse)
• A Mohebbi, MS Ebrahimzad, S Baghban Ra, M Saeidi, A Tabarraei, SR Mohebbi, S Shirian, A Gorji, A Ghaemi Non-replicating Newcastle Disease Virus as an adjuvant for DNA vaccine enhances antitumor efficacy through the induction of TRAIL and granzyme B expression Virus Res., 2018-12-29;261(0):72-80. 2018-12-29 [PMID: 30599161] (Mouse)
• K Abdi, K Laky, K Padhan, C Petrovas, J Skinner, J Kabat, DW Dorward, J Brzostowsk, EO Long, G Trinchieri, R Varma Cutting Edge: Quantitative Determination of CD40L Threshold for IL-12 and IL-23 Production from Dendritic Cells J. Immunol., 2018-10-12;0(0):. 2018-10-12 [PMID: 30315139] (Mouse)
• RH Du, Y Zhou, ML Xia, M Lu, JH Ding, G Hu ?-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering ?-arrestin2-TAB1 interaction in astrocytes J Neuroinflammation, 2018-09-10;15(1):258. 2018-09-10 [PMID: 30200997] (Mouse)
• JA Barrett, H Cai, J Miao, PD Khare, P Gonzalez, J Dalsing-He, G Sharma, T Chan, LJN Cooper, F Lebel Regulated intratumoral expression of IL-12 using a RheoSwitch Therapeutic System� (RTS�) gene switch as gene therapy for the treatment of glioma Cancer Gene Ther., 2018-05-14;0(0):. 2018-05-14 [PMID: 29755109] (Mouse)
• HM Song, X Li, YY Liu, WP Lu, ZH Cui, L Zhou, D Yao, HM Zhang Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS Int. J. Mol. Med., 2018-03-27;0(0):. 2018-03-27 [PMID: 29620148] (Mouse)
• BG Lania, J Morari, AL Souza, MND Silva, AR de Almeida, G Veira-Dami, SM Alegre, CL César, LA Velloso, ML Cintra, NB Maia, PENF Velho Topical use and systemic action of green and roasted coffee oils and ground oils in a cutaneous incision model in rats (Rattus norvegicus albinus) PLoS ONE, 2017-12-13;12(12):e0188779. 2017-12-13 [PMID: 29236720] (Rat)
• YT Lee, CT Wu, HL Sun, JL Ko, KH Lue Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine J Microbiol Immunol Infect, 2017-06-29;0(0):. 2017-06-29 [PMID: 28709839] (Mouse)
• U Lampreht T, L Loiacono, M Cemazar, U Kamensek, VM Fazio, G Sersa, E Signori Gene Electrotransfer of Plasmid-Encoding IL-12 Recruits the M1 Macrophages and Antigen-Presenting Cells Inducing the Eradication of Aggressive B16F10 Murine Melanoma Mediators Inflamm., 2017-05-16;2017(0):5285890. 2017-05-16 [PMID: 28596641] (Mouse)
• MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection J. Immunol., 2017-06-02;0(0):. 2017-06-02 [PMID: 28576981] (Mouse)
• S Ishikawa, T Ishikawa, C Tezuka, K Asano, M Sunagawa, T Hisamitsu Efficacy of Juzentaihoto for Tumor Immunotherapy in B16 Melanoma Metastasis Model Evid Based Complement Alternat Med, 2017-02-12;2017(0):6054706. 2017-02-12 [PMID: 28286532] (Mouse)
• L Li, W Wang, H Pan, G Ma, X Shi, H Xie, X Liu, Q Ding, W Zhou, S Wang Microwave ablation combined with OK-432 induces Th1-type response and specific antitumor immunity in a murine model of breast cancer J Transl Med, 2017-01-31;15(1):23. 2017-01-31 [PMID: 28137271] (Mouse)
• Maja Cemazar Tailor-made fibroblast-specific and antibiotic-free interleukin 12 plasmid for gene electrotransfer-mediated cancer immunotherapy Plasmid, 2016-11-24;89(0):9-15. 2016-11-24 [PMID: 27890562] (Human, Mouse)
• Supeng Yin Subtilisin-like protease-1 secreted through type IV secretion system contributes to high virulence of Streptococcus suis 2 Sci Rep, 2016-06-08;6(0):27369. 2016-06-08 [PMID: 27270879] (Mouse)
• Gallagher K, Joshi A, Carson W, Schaller M, Allen R, Mukerjee S, Kittan N, Feldman E, Henke P, Hogaboam C, Burant C, Kunkel S Epigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes. Diabetes, 2014-11-03;64(4):1420-30. 2014-11-03 [PMID: 25368099] (Mouse)
• Saha A, Biswas A, Srivastav S, Mukherjee M, Das P, Ukil A Prostaglandin E2 negatively regulates the production of inflammatory cytokines/chemokines and IL-17 in visceral leishmaniasis. J Immunol, 2014-07-21;193(5):2330-9. 2014-07-21 [PMID: 25049356] (Mouse)
• de Oliveira D, Hastreiter A, Mello A, de Oliveira Beltran J, Oliveira Santos E, Borelli P, Fock R The effects of protein malnutrition on the TNF-RI and NF-kappaB expression via the TNF-alpha signaling pathway. Cytokine, 2014-07-06;69(2):218-25. 2014-07-06 [PMID: 25005154] (Mouse)
• Gupta P, Giri J, Srivastav S, Chande A, Mukhopadhyaya R, Das P, Ukil A Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response. FASEB J, 2014-01-03;28(4):1756-68. 2014-01-03 [PMID: 24391131] (Mouse)
• Kamensek , Urska, Sersa , Gregor, Cemazar , Maja Evaluation of p21 promoter for interleukin 12 radiation induced transcriptional targeting in a mouse tumor model. Mol Cancer, 2013-11-12;12(1):136. 2013-11-12 [PMID: 24219565] (Mouse)
• Maina , Virginia, Marrella , Veronica, Mantero , Stefano, Cassani , Barbara, Fontana , Elena, Anselmo , Achille, Del Prete , Annalisa, Sozzani , Silvano, Vezzoni , Paolo, Poliani , Pietro L, Villa , Anna Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration. J Leukoc Biol, 2013-09-19;94(6):1221-30. 2013-09-19 [PMID: 24052573] (Mouse)
• Toki S, Goleniewska K, Huckabee M, Zhou W, Newcomb D, FitzGerald G, Lawson W, Peebles R PGI(2) signaling inhibits antigen uptake and increases migration of immature dendritic cells. J Leukoc Biol, 2013-04-26;94(1):77-88. 2013-04-26 [PMID: 23625201] (Mouse)
• Guo Z, Wen Z, Qin A, Zhou Y, Liao Z, Liu Z, Liang Y, Ren T, Xu L Antisense oligonucleotide treatment enhances the recovery of acute lung injury through IL-10-secreting M2-like macrophage-induced expansion of CD4+ regulatory T cells. J Immunol, 2013-03-20;190(8):4337-48. 2013-03-20 [PMID: 23514739] (Mouse)
• Lipinski T, Fitieh A, St Pierre J, Ostergaard H, Bundle D, Touret N Enhanced immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to dendritic cells via Dectin-1 by incorporating beta-glucan. J Immunol, 2013-03-20;190(8):4116-28. 2013-03-20 [PMID: 23514738] (Mouse)
• Owens BM, Beattie L, Moore JW, Brown N, Mann JL, Dalton JE, Maroof A, Kaye PM IL-10-Producing Th1 Cells and Disease Progression Are Regulated by Distinct CD11c+ Cell Populations during Visceral Leishmaniasis. PLoS Pathog., 2012-07-26;8(7):e1002827. 2012-07-26 [PMID: 22911108] (Mouse)
• Calderon J, Maganto-Garcia E, Punzon C, Carrion J, Terhorst C, Fresno M The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi. PLoS Pathog., 2012-07-12;8(7):e1002799. 2012-07-12 [PMID: 22807679] (Mouse)
• TLR-mediated distinct IFN-gamma/IL-10 pattern induces protective immunity against murine visceral leishmaniasis. Eur. J. Immunol., 2012-08-01;42(8):2087-99. 2012-08-01 [PMID: 22622993] (Mouse)
• Noh KT, Son KH, Jung ID, Kang HK, Hwang SA, Lee WS, You JC, Park YM Protein kinase C delta (PKCdelta)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia. J. Biol. Chem., 2012-03-05;287(17):14226-33. 2012-03-05 [PMID: 22393041] (Mouse)
• Ghose P, Ali AQ, Fang R, Forbes D, Ballard B, Ismail N The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria. J. Immunol., 2011-06-29;187(3):1333-46. 2011-06-29 [PMID: 21715688] (Mouse)
• Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2. Am. J. Pathol., 2011-05-10;179(1):302-14. 2011-05-10 [PMID: 21703412] (Mouse)
• Reim D, Rossmann-Bloeck T, Jusek G, Prazeres da Costa O, Holzmann B Improved host defense against septic peritonitis in mice lacking MyD88 and TRIF is linked to a normal interferon response. J. Leukoc. Biol., 2011-05-31;90(3):613-20. 2011-05-31 [PMID: 21628330] (Mouse)
• Diao J, Zhao J, Winter E Tumors Suppress In Situ Proliferation of Cytotoxic T Cells by Promoting Differentiation of Gr-1+ Conventional Dendritic Cells through IL-6. J. Immunol., 2011-03-23;186(9):5058-67. 2011-03-23 [PMID: 21430223] (Mouse)
• Rau CR, Hein K, Sattler MB, Kretzschmar B, Hillgruber C, McRae BL, Diem R, Bahr M Anti-inflammatory effects of FTY720 do not prevent neuronal cell loss in a rat model of optic neuritis. Am. J. Pathol., 2011-02-26;178(4):1770-81. 2011-02-26 [PMID: 21406175] (Rat)
• Vultaggio A, Nencini F, Pratesi S, Maggi L, Guarna A, Annunziato F, Romagnani S, Parronchi P, Maggi E The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines. J. Immunol., 2011-03-09;186(8):4707-15. 2011-03-09 [PMID: 21389257] (Mouse)
• Wang H, Cheng F Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10. J. Immunol., 2011-03-02;186(0):3986. 2011-03-02 [PMID: 21368229] (Mouse)
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• Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages. J. Immunol., 2010-07-21;185(4):2044-50. 2010-07-21 [PMID: 20660352] (Mouse)
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FAQs for IL-12 p70/IL-12A (M1270). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Il12a