IL-12 p70/IL-12A Products

Description

Interleukin-12, or IL-12, also known as natural killer cell stimulatory factor (NKSF) and cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine that affects both natural killer (NK) cells and T lymphocytes. IL-12 is a heterodimer of subunit IL-12A p35 and subunit IL-12B p40 that is secreted by a wide variety of antigen presenting cells (APCs), including phagocytes, B cells and Langerhans cells. It is involved in mediating many aspects of antiviral immunity. In addition to stimulating T helper cell development, IL-12 is a potent inducer of interferon-gamma (IFN-gamma) production by T cells and NK cells. Increased IL-12 production is a consequence of EBV, CMV, LCMV or HSV infection. While it is unclear what separate effects can be attributed to each IL-12 subunit, evidence suggests IL-12A p35 is the biologically active component responsible for signal transduction via the IL-12 receptor.

Bioinformatics

Entrez	16159 Mouse 3592 Human 84405 Rat
Uniprot	NM_000882 Human NP_000873 Human NP_000873.2 Human P29459 Human P29460 Human
Product By Gene ID	3592
Alternate Names	CLMF p35 Cytotoxic lymphocyte maturation factor 35 kDa subunit IL-12 subunit p35 IL-12, subunit p35 interleukin 12, p35 interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocytematuration factor 1, p35) interleukin-12 alpha chain interleukin-12 subunit alpha natural killer cell stimulatory factor 1, 35 kD subunit NF cell stimulatory factor chain 1 NK cell stimulatory factor chain 1 NKSF1 p35 p35

Research Areas for IL-12 p70/IL-12A

Find related products by research area and learn more about each of the different research areas below.

Immunology
Innate Immunity