Mouse Granzyme B DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse Granzyme B DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Gzmb

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Granzyme B DuoSet ELISA, 15 Plate

• C11
• CCPI
• CGL1
• CGL-1
• CSPB
• CSP-B
• CTLA1
• CTLA-1
• CTSGL1
• Fragmentin-2
• Granzyme B
• Granzyme-2
• GranzymeB
• GRB
• GrzB
• GZMB
• HLP
• SECT

Background

Granzyme family serine proteases are stored in the granules of cytotoxic T lymphocytes and natural killer cells. Granzymes contain one S1 protease domain and are synthesized as preproproteins. Granzymes are released toward pathogen infected or transformed target cells during cellular immune reactions. Target cell entry by granzymes is through perforin channels. Granzymes trigger apoptosis by caspase-dependent and -independent mechanisms. There are five granzymes (A, B, G, H and K) in human and many more in mouse and rat.

Publications for Granzyme B (DY1865)(34)

Publications using DY1865

• Guan, SY;Ogger, PP;Farias, A;Garcia Martín, M;Nakawesi, J;Bedard, O;Baker, C;Rosenthal, N;Johansson, C; Sustained Lung Inflammation Post-SARS-CoV-2 Infection in Mice Is Associated with Increased Pulmonary T Cells European journal of immunology 2025-08-01 [PMID: 40851359] (Mouse)
• Rao, C;Cater, DT;Roy, S;Xu, J;Olivera, AG;Evans-Molina, C;Piganelli, JD;Eizirik, DL;Mirmira, RG;Sims, EK; Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of Type 1 Diabetes bioRxiv : the preprint server for biology 2024-09-19 [PMID: 39345410] (Mouse)
• Stiff, PJ;Mehrotra, S;Potkul, RK;Banerjee, S;Walker, C;Drakes, ML; Selinexor in Combination with Decitabine Attenuates Ovarian Cancer in Mice Cancers 2023-09-13 [PMID: 37760508] (Mouse)
• Camarasa, TMN;Torné, J;Chevalier, C;Rasid, O;Hamon, MA; Streptococcus pneumoniae drives specific and lasting Natural Killer cell memory PLoS pathogens 2023-07-01 [PMID: 37486946] (Mouse)
• Zhang, L;Cascio, S;Mellors, JW;Buckanovich, RJ;Osmanbeyoglu, HU; Single-cell analysis reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of ovarian cancer bioRxiv : the preprint server for biology 2023-06-09 [PMID: 37333262] (Human)
• YS Lim, AG Lee, X Jiang, JM Scott, A Cofie, S Kumar, D Kennedy, DJ Granville, H Shin NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection Cell Reports, 2023-04-17;42(4):112410. 2023-04-17 [PMID: 37071533] (Mouse)
• A Vorontsova, TJ Cooper, J Haj-Shomal, M Benguigui, S Levin, B Manobla, R Menachem, M Timaner, Z Raviv, Y Shaked Chemotherapy-induced tumor immunogenicity is mediated in part by megakaryocyte-erythroid progenitors Oncogene, 2023-01-16;0(0):. 2023-01-16 [PMID: 36646904] (Mouse)
• J Oh, E Yi, SK Jeong, S Park, SH Park BST2, a Novel Inhibitory Receptor, Is Involved in NK Cell Cytotoxicity through Its Cytoplasmic Tail Domain International Journal of Molecular Sciences, 2022-09-27;23(19):. 2022-09-27 [PMID: 36232695] (Mouse)
• K Liu, J Huang, J Liu, C Li, G Kroemer, D Tang, R Kang HSP90 mediates IFNgamma-induced adaptive resistance to anti-PD-1 immunotherapy Cancer Research, 2022-05-16;0(0):. 2022-05-16 [PMID: 35247909] (Mouse)
• S Han, M Jung, AS Kim, DY Lee, BH Cha, CW Putnam, KS Lim, DA Bull, YW Won Peptide Adjuvant to Invigorate Cytolytic Activity of NK Cells in an Obese Mouse Cancer Model Pharmaceutics, 2021-08-17;13(8):. 2021-08-17 [PMID: 34452238] (Mouse)
• L Cao, W Li, X Yang, W Zhang, M Li, H Zhang, C Qin, X Chen, R Gao Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment Cancer Gene Therapy, 2021-06-22;0(0):. 2021-06-22 [PMID: 34158625] (Mouse)
• NV Bogatcheva, ME Coleman Concentrated Secretome of Adipose Stromal Cells Limits Influenza A Virus-Induced Lung Injury in Mice Cells, 2021-03-24;10(4):. 2021-03-24 [PMID: 33804896] (Mouse)
• C Loira-Past, K Vanvarenbe, B Ucakar, M Machado Fr, A Staub, M Lemaire, JC Renauld, R Vanbever Encapsulation of a CpG oligonucleotide in cationic liposomes enhances its local antitumor activity following pulmonary delivery in a murine model of metastatic lung cancer International journal of pharmaceutics, 2021-03-19;600(0):120504. 2021-03-19 [PMID: 33753161] (Mouse)
• SY Kim, JS Shin, KS Chung, HS Han, HH Lee, JH Lee, SY Kim, YW Ji, Y Ha, J Kang, YK Rhee, KT Lee Immunostimulatory Effects of Live Lactobacillus sakei K040706 on the CYP-Induced Immunosuppression Mouse Model Nutrients, 2020-11-22;12(11):. 2020-11-22 [PMID: 33266362] (Mouse)
• SM Miri, MS Ebrahimzad, E Abdolalipo, M Yazdi, H Hosseini R, A Ghaemi Synergy between hemagglutinin 2 (HA2) subunit of influenza fusogenic membrane glycoprotein and oncolytic Newcastle disease virus suppressed tumor growth and further enhanced by Immune checkpoint PD-1 blockade Cancer Cell Int., 2020-08-07;20(0):380. 2020-08-07 [PMID: 32782438] (Mouse)
• M Timaner, R Kotsofruk, Z Raviv, K Magidey, D Shechter, T Kan, A Nevelsky, S Daniel, EGE de Vries, T Zhang, O Kaidar-Per, RS Kerbel, Y Shaked Microparticles from tumors exposed to radiation promote immune evasion in part by PD-L1 Oncogene, 2019-08-29;0(0):. 2019-08-29 [PMID: 31467431] (Mouse)
• Junqing Hu, Jinhao Xu, Mingyue Li, Yanping Zhang, Huaiqiang Yi, Jiangning Chen et al. Targeting Lymph Node Sinus Macrophages to Inhibit Lymph Node Metastasis Molecular Therapy - Nucleic Acids 2019-06-07 [PMID: 31121477] (Mouse)
• JM Yingling, WT McMillen, L Yan, H Huang, JS Sawyer, J Graff, DK Clawson, KS Britt, BD Anderson, DW Beight, D Desaiah, MM Lahn, KA Benhadji, MJ Lallena, RB Holmgaard, X Xu, F Zhang, JR Manro, PW Iversen, CV Iyer, RA Brekken, MD Kalos, KE Driscoll Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-? receptor type I inhibitor Oncotarget, 2017-12-31;9(6):6659-6677. 2017-12-31 [PMID: 29467918] (Mouse)
• K Cook, I Daniels, P Symonds, T Pitt, M Gijon, W Xue, R Metheringh, L Durrant, V Brentville Citrullinated ?-enolase is an effective target for anti-cancer immunity Oncoimmunology, 2017-11-06;7(2):e1390642. 2017-11-06 [PMID: 29308319] (Mouse)
• A Latanova, S Petkov, Y Kuzmenko, A Kilpeläine, A Ivanov, O Smirnova, O Krotova, S Korolev, J Hinkula, V Karpov, M Isaguliant, E Starodubov Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Effects on Its Immunogenic Performance in DNA-Immunized Mice J Immunol Res, 2017-06-22;2017(0):7407136. 2017-06-22 [PMID: 28717654] (Mouse)
• ST Beug, CE Beauregard, C Healy, T Sanda, M St-Jean, J Chabot, DE Walker, A Mohan, N Earl, X Lun, DL Senger, SM Robbins, P Staeheli, PA Forsyth, T Alain, EC LaCasse, RG Korneluk Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma Nat Commun, 2017-02-15;8(0):. 2017-02-15 [PMID: 28198370] (Mouse)
• N Lavender, J Yang, SC Chen, J Sai, CA Johnson, P Owens, GD Ayers, A Richmond The Yin/Yan of CCL2: a minor role in neutrophil anti-tumor activity in vitro but a major role on the outgrowth of metastatic breast cancer lesions in the lung in vivo BMC Cancer, 2017-01-31;17(1):88. 2017-01-31 [PMID: 28143493] (Mouse)
• NK cells activated by Interleukin-4 in cooperation with Interleukin-15 exhibit distinctive characteristics Proc Natl Acad Sci USA, 2016-08-22;0(0):. 2016-08-22 [PMID: 27551096] (Mouse)
• Cannabinoid receptor 2 modulates susceptibility to experimental cerebral malaria through a CCL17-dependent mechanism J Biol Chem, 2016-07-29;0(0):. 2016-07-29 [PMID: 27474745] (Mouse)
• Brentville V, Metheringham R, Gunn B, Symonds P, Daniels I, Gijon M, Cook K, Xue W, Durrant L Citrullinated Vimentin Presented on MHC-II in Tumor Cells Is a Target for CD4+ T-Cell-Mediated Antitumor Immunity. Cancer Res, 2015-12-30;76(3):548-60. 2015-12-30 [PMID: 26719533] (Mouse)
• Crosby E, Clark M, Novais F, Wherry E, Scott P Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major. J Immunol, 2015-08-19;195(7):3301-10. 2015-08-19 [PMID: 26290604] (Mouse)
• Mac-Daniel L, Buckwalter M, Berthet M, Virk Y, Yui K, Albert M, Gueirard P, Menard R Local immune response to injection of Plasmodium sporozoites into the skin. J Immunol, 2014-06-30;193(3):1246-57. 2014-06-30 [PMID: 24981449] (Mouse)
• Furuya Y, Roberts S, Hurteau G, Sanfilippo A, Racine R, Metzger D Asthma increases susceptibility to heterologous but not homologous secondary influenza. J Virol, 2014-06-04;88(16):9166-81. 2014-06-04 [PMID: 24899197] (Mouse)
• Martinu , Tereza, Kinnier , Christin, Sun , Jesse, Kelly , Francine, Nelson , Margaret, Garantziotis , Stavros, Foster , W Michae, Palmer , Scott M Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease. PLoS ONE, 2014-05-20;9(5):e97951. 2014-05-20 [PMID: 24844383] (Mouse)
• Quintin J, Voigt J, van der Voort R, Jacobsen I, Verschueren I, Hube B, Giamarellos-Bourboulis E, van der Meer J, Joosten L, Kurzai O, Netea M Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice. Eur J Immunol, 2014-05-27;44(8):2405-14. 2014-05-27 [PMID: 24802993] (Mouse)
• Crosby E, Goldschmidt M, Wherry E, Scott P Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection. PLoS Pathog, 2014-02-27;10(2):e1003970. 2014-02-27 [PMID: 24586170] (Mouse)
• Paolino , Magdalen, Choidas , Axel, Wallner , Stephani, Pranjic , Blanka, Uribesalgo , Iris, Loeser , Stefanie, Jamieson , Amanda M, Langdon , Wallace, Ikeda , Fumiyo, Fededa , Juan Pab, Cronin , Shane J, Nitsch , Roberto, Schultz-Fademrecht , Carsten, Eickhoff , Jan, Menninger , Sascha, Unger , Anke, Torka , Robert, Gruber , Thomas, Hinterleitner , Reinhard, Baier , Gottfrie, Wolf , Dominik, Ullrich , Axel, Klebl , Bert M, Penninger , Josef M The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature, 2014-02-19;507(7493):508-12. 2014-02-19 [PMID: 24553136] (Mouse)
• Johnson RM, Kerr MS, Slaven JE Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract. J. Immunol., 2012-01-11;188(4):1896-904. 2012-01-11 [PMID: 22238459] (Mouse)
• Loebbermann J, Thornton H, Durant L Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol, 2012-01-11;5(2):161-72. 2012-01-11 [PMID: 22236998] (Mouse)

FAQs for Granzyme B (DY1865). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: Gzmb